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SUMMARY:BioE Seminar Series Presents Erica Pratt
DESCRIPTION:Department of Bioengineering Seminar Series presents: \nErica Pratt\, Ph.D  \nAssistant Professor\, Department of Biomedical Engineering\, Boston University\, Boston MA \n“Liquid biopsy approaches in pancreatic cancer”  \nWednesday\, October 26th\, 2022\n12:00 pm – 1:00 pm EST\n105 Shillman Hall  \nABSTRACT:    \nOnly 25% of pancreatic ductal adenocarcinoma (PDA) patients with localized disease survive five years after a ‘curative’ resection. It is hypothesized that PDA undergoes dissemination at the earliest stages of tumorigenesis\, driving the formation of micrometastases that go undetected using conventional screening methods. The development of high-specificity\, high-sensitivity biomarkers is critical to improving patient outcomes. Growing evidence suggests circulating tumor DNA (ctDNA) is an ideal candidate to fill this gap. ctDNA has been successfully used as a noninvasive prognostic biomarker in multiple solid tumor types. However\, pancreatic cancer remains intractable due to its intrinsically low molecular signal and fast timeline to progression. To address this need\, we have developed a digital PCR (dPCR)-based platform for rapid\, flexible\, and multiplexed ctDNA detection. Our approach for sensitive detection of low abundance ctDNA is a promising tool for modular and scalable mutation profiling.  \nBIO:   \nErica D. Pratt is an assistant professor of Biomedical Engineering at Boston University. Her lab works at the interface of engineering\, chemical biology and oncology to develop assays for cancer diagnosis and monitoring. She earned her B.S. in Mechanical Engineering and Biomedical Engineering from Carnegie Mellon University. Erica went on to earn her Ph.D. in Biomedical Engineering at Cornell University working with Brian J. Kirby. There she co-designed the Geometrically Enhanced Differential Immunocapture (GEDI) platform for high-efficiency and high-purity microfluidic isolation of circulating tumor cells from whole blood samples. Erica then completed multi-disciplinary postdocs with Andrew D. Rhim and Laurie L. Parker developing assays for non-invasive omic characterization of solid cancers.
URL:https://coe.northeastern.edu/event/bioe-seminar-series-presents-erica-pratt/
ORGANIZER;CN="Bioengineering":MAILTO:bioe@northeastern.edu
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DTSTART;TZID=America/New_York:20221026T120000
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SUMMARY:Modular and Composite Approaches to Engineering Challenging Tissues with Polysaccharide Materials
DESCRIPTION:ChE Seminar Series Presents: \nHoward W.T. Matthew\, PhD \nProfessor\, Chemical Engineering\, Wayne State University \nAbstract: \nPolysaccharides have long been recognized as polymeric materials with an array of properties that have made them indispensable for applications ranging from adhesives to property-enhancing nanomaterials.  As a result\, they have found wide acceptance as food and drug additives.  Over the past thirty years\, a growing body of work has served to raise their profile as effectors and modulators of receptor-based phenomena including immune recognition as well as cell-matrix\, cell-pathogen\, and cell-growth factor interactions.  However\, these materials remained underutilized as components of implantable systems.  Within the last decade\, the explosion of research in tissue engineering and regenerative medicine has increased demand for biologically active materials\, and polysaccharides are receiving greater attention for their ability to facilitate tissue assembly and organization in vitro and in vivo.  While many polysaccharides possess potentially useful biological activities\, their mode of application has mainly been in bulk hydrogel form.  The Matthew group has been working with polyelectrolyte ionic complexes formed between oppositely charged polysaccharides.  These ionic complex membranes can be rendered as hollow microcapsules of controllable size.  This presentation will describe our ongoing studies focused on deploying these capsules as a versatile tool for generating tissue organoids and as a platform for assembling vascularized tissues with a range of physical and biological properties. \nBio: \nHoward Matthew is a Professor of Chemical Engineering and Materials Science at Wayne State University (WSU) in Detroit\, Michigan.  He received a B.Sc. degree in Chemical Engineering (1984) from the University of the West Indies\, Trinidad.  After two years in the food processing industry\, he joined Wayne State University for graduate studies\, receiving an M.S. degree in 1988 and a Ph.D. in 1992.  He conducted two years of postdoctoral research at Harvard Medical School and the Massachusetts General Hospital.  He then joined the WSU faculty as an Assistant Professor in 1994.  He is a recipient of the National Science Foundation’s Early Faculty CAREER Award (1996)\, and was elected as a Fellow of the American Institute of Medical and Biological Engineering (AIMBE\, 2012).  His research spans the fields of biomaterials and tissue engineering\, focusing on the use of polysaccharide materials in tissue design and assembly.  His work has two broad themes: modulating the mechanics and biological activity of polysaccharide materials; and developing methods to apply these materials in cell and tissue-based therapies.  Target applications include: heart valves for pediatric applications\, designing transplantable liver tissue\, and regeneration of musculoskeletal structures after surgical or traumatic loss.  To date\, Prof. Matthew has been research supervisor for over 40 graduate students 55 undergraduates and 43 high school students. \n 
URL:https://coe.northeastern.edu/event/modular-and-composite-approaches-to-engineering-challenging-tissues-with-polysaccharide-materials/
LOCATION:236 Richards\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
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DTSTART;TZID=America/New_York:20221026T193000
DTEND;TZID=America/New_York:20221026T210000
DTSTAMP:20260513T185729
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SUMMARY:SWE Networking Night
DESCRIPTION:Join the Society for Women Engineers (SWE) for our annual Networking Night!  \nWhen: Wednesday\, October 26th at 7:30pm \nWhere: Curry Ballroom (second floor) \nWho: Undergraduate womxn engineers and companies representing all engineering majors \nWhy: Become more comfortable networking and build relationships with industry professionals! \nThis is a unique opportunity for undergraduate womxn engineers to chat about professional development with engineers and recruiters from 20+ companies. Learn more about job opportunities\, interview tips\, resume help\, career trajectory\, etc. in a low-pressure environment! \nCheck out our event on Engage!
URL:https://coe.northeastern.edu/event/swe-networking-night/
LOCATION:Curry Student Center\, 360 Huntington Ave.\, Boston\, MA\, 02115\, United States
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