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DTSTART;TZID=America/New_York:20221109T120000
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DTSTAMP:20260511T160326
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UID:33629-1667995200-1667998800@coe.northeastern.edu
SUMMARY:Leveraging the Natural Cellular and Biomolecular Interactions in Blood for the Design of Targeted\, Anti-Inflammatory Particle Therapeutics
DESCRIPTION:ChE Seminar Series Presents:  \nDr. Omolola (Lola) Eniola-Adefeso \nAssociate Dean for Graduate and Professional Education in the College of Engineering at the University of Michigan-Ann Arbor \nAbstract:  \nVascular-targeted particle therapeutics offer the possibility of increased drug effectiveness while minimizing side effects often associated with systemic drug administration. Factors that influence the likelihood of targeted particle therapeutics to reach the vascular wall are the ability to identify: 1) a disease-specific target\, 2) the appropriate drug carrier type and geometry for efficient interaction with the vascular wall\, and 3) a drug-carrier combination that allows for the desired release of the targeted therapeutics. Our work focuses on probing the role of particle geometry\, material chemistry\, and blood rheology/dynamics on the ability of vascular-targeted drug carriers to interact with the blood vessel wall – an important consideration that will control the effectiveness of drug targeting regardless of the targeted disease or delivered therapeutically. This presentation will highlight the carrier-blood cell interactions that affect drug carrier binding to the vascular wall and alter critical neutrophil functions in disease. The talk will present the material design parameters for optimal drug carriers’ design for active and passive use in treating acute lung injury and other inflammatory diseases. \nBio: \nDr. Omolola (Lola) Eniola-Adefeso is the University Diversity and Social Transformation Professor of Chemical Engineering and Biomedical Engineering and the Associate Dean for Graduate and Professional Education in the College of Engineering at the University of Michigan-Ann Arbor.  She received a doctoral degree (2004) in Chemical and Biomolecular Engineering at the University of Pennsylvania. She was a postdoctoral associate in the Pediatrics/Leukocyte Biology at Baylor College of Medicine. Dr. Eniola-Adefeso joined the faculty of Chemical Engineering at the University of Michigan in 2006\, where she runs the Cell Adhesion and Drug Delivery Laboratory.   Since she arrived at Michigan\, Dr. Eniola-Adefeso has received several honors and awards\, including the NSF CAREER Award\, American Heart Association Innovator Award\, and most recently\, the BMES MIDCAREER Award. She is a fellow of the American Institute for Medical and Biological Engineering (AIMBE) and the Biomedical Engineering Society and serves as Deputy Editor for Science Advances. Her research is currently funded by multiple grants from the NIH NHLBI\, American Heart Association\, and the National Science Foundation. \n 
URL:https://coe.northeastern.edu/event/leveraging-the-natural-cellular-and-biomolecular-interactions-in-blood-for-the-design-of-targeted-anti-inflammatory-particle-therapeutics/
LOCATION:236 Richards\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
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DTSTART;TZID=America/New_York:20221109T120000
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DTSTAMP:20260511T160326
CREATED:20221107T182254Z
LAST-MODIFIED:20221107T182254Z
UID:34237-1667995200-1667998800@coe.northeastern.edu
SUMMARY:Bernard Herrera-Soukup PhD Dissertation Defense
DESCRIPTION:“Ferroelectric Micro-machined Ultrasonic Transducers for Biomedical and Processing In-Sensor Applications” \nAbstract: \nPiezoelectric Micromachined Ultrasonic Transducers (PMUTs) are Micro Electro-Mechanical Systems (MEMS) devices that have become an established technology in applications such as range-finding\, fingerprint sensing and imaging due to their capability of ultrasonic transduction in a miniaturized footprint\, easily amenable to create large arrays. However\, their application space still remains quite open. PMUTs are well fitted to applications in liquid media\, such as implantable and underwater devices\, due to their inherent acoustic matching and wide bandwidth. Thus\, in the first part of the dissertationl\, we explore novel applications such as PMUT-based intra-body and underwater networking\, power transfer\, source localization\, wide-band matching and duplexing. \nAluminum Nitride (AlN) has been the material of choice for our PMUTs due to its biocompatibility and possibility of single-chip integration with supporting CMOS circuitry. Scandium doping of AlN thin films has recently been demonstrated to increase piezoelectric coupling coefficients while introducing ferroelectric properties in the material. However\, a simultaneous use of both capabilities has not been demonstrated in the state-of-the-art. The ability of having distinct ferroelectric states\, that alter the mechanical performance of the devices\, allows for Processing-In-Sensor features and provides the building blocks for neuromorphic signal processing capabilities. The second part of the dissertation explores the AlScN material integration into novel Ferroelectric Micromachined Ultrasonic Transducers (FMUTs) and their emerging application space. \n  \nCommittee: \nProf. Matteo Rinaldi (Advisor)\nProf. Tommaso Melodia\nProf. Cristian Cassella
URL:https://coe.northeastern.edu/event/bernard-herrera-soukup-phd-dissertation-defense/
LOCATION:432 ISEC\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
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