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DTSTART;TZID=America/New_York:20240124T100000
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DTSTAMP:20260518T130929
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SUMMARY:CHE PhD Dissertation Defense: Shicheng Yang
DESCRIPTION:PhD Dissertation Defense: Drug Delivery Systems in Oncology: From Polymeric Implants to Nanomedicine Approaches \nShicheng Yang \nLocation: Hastings Hall 107 & Zoom \nAbstract: Molecular inhibitors\, including PARP inhibitor talazoparib\, CDK inhibitor dinaciclib\, and docetaxel\, are critical in precision cancer therapy\, offering novel therapeutic options for a range of cancers. While demonstrating potent activity as monotherapy or in combination in both preclinical and clinical settings\, challenges such as drug resistance and off-target toxicity persist with these small molecule drugs. To mitigate these issues\, innovative formulation strategies using implants or nanoparticles have been explored. These formulations are designed to alter drug uptake pathways\, resist the emergence of drug resistance\, and minimize direct contact with healthy tissues\, thereby reducing toxicity. This thesis encompasses several nanotechnology approaches in formulating chemotherapy agents and their application across various cancers\, including breast\, ovarian\, pancreatic\, lung\, and prostate. \nIn the context of ovarian cancer\, known for its high mortality rate within the realm of female reproductive system cancers\, more than 15% of cases involve defective BRCA-mediated homologous recombination repair pathways. Talazoparib\, a PARP inhibitor\, has been hindered in its clinical application due to severe systemic side effects. The development of a novel TLZ-loaded PLGA implant (InCeT-TLZ) is reported\, designed for sustained release over 25 days directly into the peritoneal cavity\, targeting BRCA-mutated metastatic ovarian cancer. Results from in vivo experiments indicated a doubling of survival in the InCeT-TLZ treated group compared to controls\, with no significant toxicity observed in surrounding peritoneal organs. This suggests that localized and sustained delivery of Talazoparib can enhance therapeutic efficacy without significant toxicity. Additionally\, the potential of combining CKD inhibitor and PI3K inhibitor with InCeT-TLZ to counteract acquired PARPi resistance was demonstrated in vitro\, indicating a promising approach for enhanced ovarian cancer treatment. \nWhile the biodegradable PLGA implants showed potency\, the conventional solvent-based fabrication methods used to synthesize these implants\, however\, the use of toxic organic solvent and its safety issue pose difficulties for translation to clinical use. To address these challenges\, a scalable\, solvent-free hot-melt extrusion process was introduced for producing PLGA implants iii with docetaxel. This process ensures uniform dispersion of clinically relevant concentrations of the drug without requiring organic solvents. Results showed the bioactivity of incapsulated docetaxel was maintained during fabrication and controlled degradation\, enhancing tumor growth inhibition capabilities both in vitro and in vivo. The implants\, when used intratumorally\, act as both radiosensitizers and continuous chemotherapy sources\, suitable for scale-up in compliance with Good Manufacturing Practices (GMP). \nFurthermore\, the combination of talazoparib and dinaciclib has been studied to overcome PARPi resistance in tumors. The short blood circulation time of dinaciclib and the high toxicity of combination therapies pose significant challenges. Nanomedicine formulations have been developed to address these issues\, creating a nano-cocktail of talazoparib (nTLZ) and dinaciclib (nDCB) to enhance therapeutic efficacy at lower doses. The study showed that these nanoformulations effectively infiltrate tumor cells\, with synergistic effects observed in both BRCAmutant and BRCA wild-type cancer strains\, particularly sensitizing BRCA wild-type cells to PARPi therapy. This approach demonstrates the potential of nanoformulations in broadening the applicability and enhancing the efficacy of combination cancer therapies.
URL:https://coe.northeastern.edu/event/che-phd-dissertation-defense-shicheng-yang/
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DTSTART;TZID=America/New_York:20240124T170000
DTEND;TZID=America/New_York:20240124T180000
DTSTAMP:20260518T130929
CREATED:20240122T153928Z
LAST-MODIFIED:20240122T153928Z
UID:41599-1706115600-1706119200@coe.northeastern.edu
SUMMARY:Poster Design and Content:  A CommLab Workshop Series
DESCRIPTION:The CommLab will host a three-part workshop series for poster design to focus on crafting the best visual communication of your research! With the upcoming PhD Research Expo\, we will discuss techniques and implement communication strategies to successfully showcase your work. Join us for the first installment on Wednesday\, January 24th from 5:00-6:00 PM in Curry Student Center 336 and on Zoom. Also join us on Wednesday\, January 31 to polish your poster and on February 21 to practice your poster pitch.  See you there!
URL:https://coe.northeastern.edu/event/poster-design-and-content-a-commlab-workshop-series/2024-01-24/
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DTSTART;TZID=America/New_York:20240124T173000
DTEND;TZID=America/New_York:20240124T183000
DTSTAMP:20260518T130929
CREATED:20231206T205350Z
LAST-MODIFIED:20231206T205350Z
UID:40750-1706117400-1706121000@coe.northeastern.edu
SUMMARY:Global Co-op Information Session
DESCRIPTION:Join the College of Engineering Global Co-op team in learning about global co-op opportunities for Summer II/ Fall 2024! \nTopics discussed will include: \n\nSearch techniques and global positions in your field\nLocations that students have co-oped in the past\nWhat to consider when interested in a global co-op\nInformation on logistics\, including visas and housing\nTips and resources for self-developing global positions\n\nAttendance to one of these information sessions is required if you plan to do a global co-op in Summer II/ Fall 2024. \nLocation: Renaissance Park 909. Register on NUworks. \nPlease reach out to Kristina Hubbard\, Global Co-op Coordinator\, k.hubbard@northeastern.edu for additional information.
URL:https://coe.northeastern.edu/event/global-co-op-information-session-2/
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