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X-WR-CALDESC:Events for Northeastern University College of Engineering
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DTSTART;TZID=America/New_York:20240613T090000
DTEND;TZID=America/New_York:20240613T110000
DTSTAMP:20260512T231041
CREATED:20240611T191401Z
LAST-MODIFIED:20240611T191401Z
UID:44269-1718269200-1718276400@coe.northeastern.edu
SUMMARY:ChE PhD Dissertation Defense: Ian Smith
DESCRIPTION:PhD Dissertation Defense: A Primary Intestinal Model to Assay Lymphatic Drug Transport \nIan Smith \nLocation: Dodge Hall 070 & Zoom \nAbstract: Lipophilic drugs (logP > 5) often fail to develop as commercial oral medications due to poor absorption\, distribution\, metabolism\, excretion and/or toxicity (ADMET) properties. Beyond-rule-of-5 (bro5) candidate attrition in the clinic may be relieved by targeted delivery to chylomicrons (CMs) as chaperones into the mesenteric lymphatics. Lymph-cannulated animal models that estimate lymphatic bioavailability (F%) are surgically challenging\, costly and highly variable between species. In vitro models of the human intestinal epithelium can preserve enterocyte-like CM assembly and thereby recapitulate on the benchtop drug intercalation with CM components during transcytosis (i.e. the “lymphatic permeability” mechanism). This thesis proposes primary small intestinal epithelia as alternative platforms to the Caco-2 Transwell® culture for assaying lymphatic drug transport. \nPrimary monolayers cultured from small intestinal enteroids were investigated for CM synthesis\, secretion\, and transport of lymphotropic small molecules. The specific aims were to: 1) establish a mixed bile micelle formulation compatibile with primary cultures\, 2) develop a first-principle mathematical description of poorly water-soluble drug (PWSD) partitioning and uptake from lipid-containing micelles\, 3) characterize apolipoprotein B (apoB)-containing lipoprotein secretion from primary cultures along an oleic acid (OA)/2-monoloein (2-MO) stimulation axis\, and 4) compare CM-transported drug in culture to lymph-cannulated F% estimations. Exposure of mixed bile micelles containing 4:1 taurocholate (TC) and phosphatidylcholine (PC) to the brush border membrane of human duodenum (hDuo) and Caco-2/HT29-MTX co-cultures (Co-C) compromised tight junctional resistance and paracellular permeability in Co-C above 5 mM TC whereas hDuo were unaffected. Permeability measurements in the Co-C monolayer showed PWSD transport from TC/PC micelles to be reasonably predicted by changes in the apical (i.e. lumen-side) free or total drug concentration (CD\,free or CD\,total)\, but extent of fatty acid (FA)-induced supersaturation was limited by lipo-toxicity. Over a time course aligned to the window of lymph triglyceride (TG) turnover in vivo (i.e. 6 hours)\, controlled 2-monooloein (2-MO) stimulation of hDuo and murine ileum (mIle) monolayers induced significant increases in TG mass (~3.5-fold) and particle diameter (Dh) (~2-fold) of  < 1.006 g/mL lipoproteins. Primary enterocytes upregulated mgat2 transcription in the presence of 2-MO substrate to indicate that TG output in these FBS-differentiated cultures engaged the sn-1\,2-monoglyceride (2-MG) re-esterification pathway. Organoid cultures also favored basal-polarized apoB-48 release distinct from the bidirectional apoB-100 output of Caco-2. Finally\, apparent permeability of halofantrine (Hf; logP 7.34; BCS Class II) and navitoclax (Nx; logP 7.93; BCS Class IV) in CMs secreted from mIle but not Caco-2 were increased from TC/PC control conditions by inclusion of +OA/2-MO in micelles. For Hf\, the fraction of dose absorbed by CMs (faCM = 6.8 ± 0.9%) was similar to the fraction of dose transported into the lymph of cannulated rats (falymph = 5.5 ± 0.8%). \nDevelopment of an in vitro-in vivo correlation between lymph-cannulated animals and the primary transport assay developed herein might assist preclinical programs in translating lipid-based oral modalities to humans. Expansion of the organoid donor set (by species and small intestinal region)\, combinatorial probing of more lipid stimulation axes (by substrate chain length and saturation)\, and scaling of monolayer culture could refine the lymphatic assay into a high-throughput screen. Beyond a drug delivery context\, de novo CM assembly in enterocytes that retain a native small intestinal phenotype enables closed-system study of outstanding questions regarding intestinal lipoprotein formation and dyslipidemia disease intervention.
URL:https://coe.northeastern.edu/event/che-phd-dissertation-defense-ian-smith/
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DTSTART;TZID=America/New_York:20240613T113000
DTEND;TZID=America/New_York:20240613T153000
DTSTAMP:20260512T231041
CREATED:20240529T135019Z
LAST-MODIFIED:20240529T135019Z
UID:44053-1718278200-1718292600@coe.northeastern.edu
SUMMARY:Juneteenth Celebration
DESCRIPTION:Join us for this Juneteenth celebration\, where there will be a time for education via a hybrid panel discussion\, followed by a time of celebration at an outdoor festival. \n\nPanel discussion 11:30 a.m. – 1:00 p.m. (ET)\, in-person at The Cabral Center\, John D. O’Bryant African American Institute and online. (Registration required; registration link coming soon at https://www.northeastern.edu/aai/ )\n\n\nOutdoor celebration 1:30 p.m. – 3:30 p.m. (ET)\, in-person\, Centennial Common\n\nPanel discussion:  “Understanding the Reparations Movement”\, offers an in-depth exploration of a critical issue in American history and its contemporary relevance globally\, nationally\, and locally. \nModerator: Dr. Régine Jean-Charles\, Dean’s Professor Culture and Social Justice; Director Africana Studies \nPanelists: \n\nDr. Deborah Jackson\, Northeastern’s Reparations Research Team\nDr. Ashley Adams\, Northeastern’s Black Reparations Project\nJoseph Feaster\, Esq.\, City of Boston Reparations Task Force\nElizabeth Tiblanc\, Embrace Boston Harm Report\n\n Outdoor Festival Celebration:  1:30 p.m. – 3:30 p.m. Centennial Common will hold celebratory activities that include vendors of local black-owned businesses\, musical performances\, food trucks\, and more.
URL:https://coe.northeastern.edu/event/juneteenth-celebration/
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240613T120000
DTEND;TZID=America/New_York:20240613T130000
DTSTAMP:20260512T231041
CREATED:20240603T134811Z
LAST-MODIFIED:20240603T134811Z
UID:44060-1718280000-1718283600@coe.northeastern.edu
SUMMARY:Galante Luncheon Info Session
DESCRIPTION:Join us for the Galante Engineering Business Program Luncheon Info Session on Thursday\, June 13th from 12 pm to 1 pm in Shillman 320. Features an overview\, panel discussion\, exclusive giveaways\, and lunch! Please RSVP and email galante@northeastern.edu with any questions.
URL:https://coe.northeastern.edu/event/galante-luncheon-info-session/
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240613T160000
DTEND;TZID=America/New_York:20240613T170000
DTSTAMP:20260512T231041
CREATED:20240517T125021Z
LAST-MODIFIED:20240603T191426Z
UID:44136-1718294400-1718298000@coe.northeastern.edu
SUMMARY:Mock Interview: CommLab Drop-In Workshops
DESCRIPTION:Join the CommLab any Thursday from 4-5pm ET\, we’ll delve into the intricacies of interviews\, unveiling effective preparation strategies for any interview scenario. Engage in an interactive setting as we dissect the overall interview experience\, discuss common interview scenarios\, and share insights on what to do during critical moments. Join this hybrid workshop series through Zoom.
URL:https://coe.northeastern.edu/event/mock-interview-commlab-drop-in-workshops/2024-06-13/
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240613T170000
DTEND;TZID=America/New_York:20240613T180000
DTSTAMP:20260512T231041
CREATED:20240517T125712Z
LAST-MODIFIED:20240701T135455Z
UID:43932-1718298000-1718301600@coe.northeastern.edu
SUMMARY:Poster Design and Presentation: CommLab Drop-In Workshops
DESCRIPTION:The CommLab will host drop-in workshops for poster design and presentation to focus on crafting the best visual communication of your research and telling your research story! We will discuss techniques and implement communication strategies to successfully showcase your work. No matter where you are in the process\, whether it is just in the idea phase or you are trying to polish your final poster\, we are happy to help you.  Join us any Thursday from 5-6pm\,  on Zoom.
URL:https://coe.northeastern.edu/event/poster-design-and-presentation-commlab-drop-in-workshops/2024-06-13/
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