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DTSTART;TZID=America/New_York:20240911T090000
DTEND;TZID=America/New_York:20240911T110000
DTSTAMP:20260405T010728
CREATED:20240830T155557Z
LAST-MODIFIED:20241122T164823Z
UID:45475-1726045200-1726052400@coe.northeastern.edu
SUMMARY:Graduate Student Drop-In Writing Hours
DESCRIPTION:Graduate students\, are you looking for a place for focused research writing time?  Join the CommLab drop-in writing hours any Wednesday between 9 -11 am ET.  Drop in any Wednesday and stay for a short time or two hours.  A CommLab Fellow will also be available to provide feedback on your writing.  We will be meeting in weekly in 334 Curry Student Center.  Note we will meet in 336 Curry Student Center on Wednesday\, September 25th.
URL:https://coe.northeastern.edu/event/graduate-student-drop-in-writing-hours/2024-09-11/
LOCATION:Curry Student Center\, 360 Huntington Ave.\, Boston\, MA\, 02115\, United States
GEO:42.3394629;-71.0885286
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Curry Student Center 360 Huntington Ave. Boston MA 02115 United States;X-APPLE-RADIUS=500;X-TITLE=360 Huntington Ave.:geo:-71.0885286,42.3394629
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240911T090000
DTEND;TZID=America/New_York:20240911T110000
DTSTAMP:20260405T010728
CREATED:20240903T135736Z
LAST-MODIFIED:20240903T135736Z
UID:45520-1726045200-1726052400@coe.northeastern.edu
SUMMARY:ChE PhD Dissertation Defense: Ronodeep Mitra
DESCRIPTION:Name:\nRonodeep Mitra \nTitle: \nGlycocalyx Therapy to Restore Anti-Atherosclerotic Endothelial Cell Function \nDate:\n9/11/2024 \nTime:\n9:00:00 AM \nCommittee Members:\nProf. Eno Ebong (Advisor)\nProf. Mansoor Amiji\nProf. Rebecca Carrier\nProf. Arthur J. Coury\nProf. Jessica M. Oakes \nLocation:\nEXP 610 and Zoom \nAbstract:\nThe endothelial cell (EC) glycocalyx (GCX) is a negatively charged complex sugar-rich layer that lines the endothelium. It is an important contributor to the physical and biochemical health of the vasculature and endothelium\, while mediating mechanotransduction and vascular signaling. For example\, when exposed to physiological (unidirectional and uniform in magnitude) levels of shear stress from the mechanical force of blood flow\, the GCX is abundant and aids in the production of vasodilator nitric oxide (NO)\, which regulates vascular tone. Furthermore\, the dynamics of the flow-regulated GCX determine the structural integrity of connexin proteins that comprises interendothelial gap junctions and control the flow of communication between neighboring ECs. Finally\, the GCX acts as a physical barrier to numerous components in circulating blood\, including low-density lipoproteins (LDLs) and inflammatory cells such as monocytes that differentiate into macrophages and platelets. \nLoss of the EC GCX can be attributed to disturbed vasculature blood flow patterns. This condition renders the endothelium as adhesive and permeable\, resulting in infiltration of the vessel walls by blood circulating LDLs\, compromising active EC-EC communication via interendothelial gap junctions\, and reduction in NO production\, leading to vasoconstriction. These phenotypes lead to vascular dysfunction\, atherosclerosis\, and other serious secondary cardiovascular events\, such as myocardial infarctions and strokes. Hence\, we propose either repurposing therapies that were\nnot originally indicated for GCX therapy or the development of novel GCX therapies and hypothesize that targeting the EC GCX will restore vascular function and prevent further downstream cardiovascular events\, such as atherosclerosis. \nWe first tested our hypothesis by assessing the efficacy of repurposing diosmin\, a flavanone glycoside of diosmetin\, which is a nutraceutical used to currently treat chronic venous insufficiency. Previous studies have shown diosmin’s potent anti-inflammatory and anti-oxidant properties on the endothelium. Hence\, we wanted to determine if diosmin would repair mechanically damaged endothelial GCX in regions of disturbed flow (DF) patterns and restore anti-atherosclerotic endothelium mechanotransduction function. For this study\, we utilized a unique murine in vivo DF model\, where the left carotid artery (LCA) is partially ligated\, while the right carotid artery (RCA) is not surgically intervened and was the designated uniform flow (UF) control for each mouse. Diosmin treatment elevated activated endothelial NO synthase level (p-eNOS)\, inhibited inflammatory cell uptake\, decreased vessel wall thickness and increased vessel diameter\, and increased GCX coverage on the endothelium in ligated LCA. This corroborated support that diosmin protects endothelial GCX integrity and preserves complex endothelial function. \nNext\, in vitro and in vivo DF models were used to assess a novel therapy\, combining sphingosine-1-phosphate (S1P)\, a bioactive lipid mediator\, and heparin in regenerating the endothelial GCX. We used a parallel-plate flow chamber to simulate flow conditions in vitro on human coronary arterial endothelial cells (HCAECs) and a partial carotid ligation murine model to mimic DF in vivo\, as mentioned above. In vitro data showed that heparin/S1P therapy improved the function of DF-conditioned ECs by restoring the GCX and promoting EC alignment and elevated p-eNOS expression. Furthermore\, heparin/S1P treatment restored GCX in the LCA\, enhancing GCX thickness and coverage of the blood vessel wall and reducing vessel wall thickness\, demonstrating advances in a novel therapeutic that regenerates EC GCX and restores complex vascular function in DF conditions. \nThis research work is an excellent step towards the development of repurposed or novel therapeutics that can be applied to replace\, stabilize\, or protect the GCX and restore GCX-mediated EC mechanotransduction\, particularly in DF conditions. These prospective mechano-therapeutics could represent breakthrough solutions for preventing cardiovascular diseases such as atherosclerosis in the future.
URL:https://coe.northeastern.edu/event/che-phd-dissertation-defense-ronodeep-mitra/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240911T120000
DTEND;TZID=America/New_York:20240911T120000
DTSTAMP:20260405T010728
CREATED:20240906T202233Z
LAST-MODIFIED:20241001T170356Z
UID:45649-1726056000-1726056000@coe.northeastern.edu
SUMMARY:Bioengineering Fall Seminar Series
DESCRIPTION:Wednesdays 12-1pm in 105 Shillman Hall\, unless otherwise stated. All are welcome.  \nSpeakers\n\n9/6: Sara Rouhanifard\, PhD\nAssistant Professor of Bioengineering at Northeastern University\n9/11: Mingyang Lu\, PhD\nAssistant Professor of Bioengineering at Northeastern University\n9/18: Joanna Dahl\, PhD\nAssistant Professor of Engineering at the University of Massachusetts Boston \n9/25: Stirling Churchman\, PhD\nProfessor of Genetics at Harvard Medical School\n10/2: Sujit Datta\, PhD *in collaboration with CHME* (168 SN)\nProfessor of Chemical Engineering\, Bioengineering and Biophysics at California Institute of Technology\n10/9: Yizeng Li\, PhD\nAssistant Professor of Biomedical Engineering\, Binghamton University \n10/16: Song Li\, PhD\nChancellor’s Professor and Department Chair of Bioengineering at \nthe University of California Los Angeles\n10/23: Seemantini Nadkarni\, PhD\nAssociate Professor of Dermatology at Harvard Medical School \n10/30: Ahmad “Mo” Khalil\, PhD\nProfessor of Biomedical Engineering at Boston University\n11/6: Ramkumar “Ram” Annamalai\, PhD\nAssistant Professor of Biomedical Engineering at the University at Buffalo\n11/13: Brad Hyman\, MD PhD\nJohn B. Penney\, Jr. Professor of Neurology at Harvard Medical School and Massachusetts General Hospital\n11/20: Lingchong You\, PhD\nJames L. Meriam Distinguished Professor of Biomedical Engineering and the Director of the Center for Quantitative Biodesign at Duke University\n11/27: \nNone\, Thanksgiving\n12/4: Jeffrey Moffit\, PhD\nAssistant Professor in Microbiology at Harvard Medical School\n11/6: Jeffrey Fredberg\, PhD\, *Friday*\nProfessor of Bioengineering and Physiology at Harvard School for Public Health
URL:https://coe.northeastern.edu/event/bioengineering-fall-seminar-series-2/2024-09-11/
LOCATION:105 Shillman Hall\, 360 Huntington Ave\, 105 SH\, Boston\, MA\, 02115\, United States
ORGANIZER;CN="Bioengineering":MAILTO:bioe@northeastern.edu
GEO:42.337539275041;-71.090062487079
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DTSTART;TZID=America/New_York:20240911T150000
DTEND;TZID=America/New_York:20240911T160000
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LAST-MODIFIED:20240830T155657Z
UID:45467-1726066800-1726070400@coe.northeastern.edu
SUMMARY:Graduate Student Fellowship Writing Club
DESCRIPTION:Join the NU CommLab and NetSI sponsored weekly graduate student fellowship writing club for support in writing your fellowship application!  The fellowship writing club meets virtually on Wednesdays from 3-4 pm from September 4 – October 16.  We will offer you an opportunity to ask questions to faculty\, staff and students who have reviewed\, mentored or applied and received fellowships.  We will provide fellowship writing tips and guidance as well as offer writing and draft review sessions.  Register to join our Zoom Sessions.
URL:https://coe.northeastern.edu/event/graduate-student-fellowship-writing-club/2024-09-11/
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