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UID:53388-1761127200-1761130800@coe.northeastern.edu
SUMMARY:Crafting Posters with Visual Impact and Designing Poster Narratives:  CommLab Drop-In Hours
DESCRIPTION:Working on a poster? Stop by the CommLab Drop-In hours to brainstorm ideas\, get feedback and fine tune the visual and oral presentation of your research or project. Join any Wednesday from 10-11am in person in room 206 Egan or join virtually on Zoom. \n 
URL:https://coe.northeastern.edu/event/crafting-posters-with-visual-impact-and-designing-poster-narratives-commlab-drop-in-hours/2025-10-22/
LOCATION:206 Egan\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
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DTSTART;TZID=America/New_York:20251022T110000
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UID:53691-1761130800-1761141600@coe.northeastern.edu
SUMMARY:University of California Davis Graduate and Law School Fair
DESCRIPTION:Join COE Graduate Admissions at the 2025 University of California Davis Graduate and Law School Fair in Davis\, California! Ask your questions about our graduate engineering programs across the U.S. and Canada during the fair on October 22nd from 11am-2pm. We look forward to meeting you there!
URL:https://coe.northeastern.edu/event/university-of-california-davis-graduate-and-law-school-fair/
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DTSTART;TZID=America/New_York:20251022T120000
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UID:53954-1761134400-1761138000@coe.northeastern.edu
SUMMARY:Chemical Engineering Fall Seminar Series: William Doherty
DESCRIPTION:Seminar Title: Stimulating Excitable Cells with Optosomes: Development of a Non-viral Cell Derived Vesicle Capable of Stimulating Excitable Cells in Response to Light Stimulus \nLocation: 108 Snell Engineering Center \nAbstract: For years\, researchers have studied and developed neuromodulation techniques meant to stimulate and/or inhibit excitable cells both in research and clinical settings. A method to excite cells with light\, termed Optogenetics\, has been researched extensively since its discovery in the early 2000’s. A major constraint of Optogenetics is the expression of the necessary light-gated ion channels most often achieved using a viral vector. While this is not overly concerning in research settings\, clinical applications of optogenetics have been slow to develop as the use of viral vectors in humans presents challenges regarding safety. Additionally\, foreign opsin genes are believed to be a permanent addition to the transfected cells. \nThis dissertation aimed to develop Optosomes; a cell-derived vesicle containing excitatory opsin that couples with excitable cells via Gap-Junctions that conduct the stimulus current from the opsin into the cell. Initial production of Optosomes followed established protocols for producing Giant Plasma Membrane Vesicles (GPMVs) in which small volumes of cytoplasm are encapsulated in a piece of the cell’s plasma membrane. The number of GPMVs produced varied with pH\, cell confluency\, and base medium having a noticeable impact on the number of GPMVs generated. Optosome production required the creation of a stable cell line expressing Channelrhodopsin-2 (ChR2) and connexin-43 (Cx43) proteins required to form Gap-Junctions. Two separate transfections in the series generated a ChR2-Cx43 Hek293 cell line capable of producing Optosomes at a high concentration. Finally\, a mathematical model was built to simulate Optosome stimulation of excitable cells and how changes in the size of Optosomes and cells affect the strength of stimulus generated. The result of these simulations and attempts to stimulate neonatal Cardiomyocytes (CM) in vitro confirmed that the majority of Optosomes produced were too small to generate a stimulus capable of exciting CMs. Production of Optosomes with larger diameters or the use of a different strand of ChR2 is needed to increase the number of Optosomes able to stimulate CMs will be needed moving forward. \nThe results of this dissertation provide the foundation for developing Optosomes as an alternative approach to stimulating excitable cells with light. \n\nAfter spending nearly two years working on the development of a new automated Biomanufacturing system in the Love Lab\, Bill was accepted and enrolled in the PhD program for Chemical Engineering. After finding his home for the next 7 years in the Koppes Lab\, he got to work both on forming his thesis and integrating into the community at Northeastern. In pursuing his Ph. D\, he had started to appreciate how applying mathematical modeling techniques to biological systems offers a whole new perspective when trying to understand the complex innerworkings of the human body. It offered a nice juxtaposition to the time spent in lab running hands on experiments that are less about math and academic prowess and more about technique\, adaptability\, and problem solving in real time. Bill has sed the better part of his twenties working in Research and its why he was so eager to pursue a Ph D as he hopes to work his way into scientist positions overseeing research and development projects. Still residing in Boston\, he hopes to find a position in the New England Area after submitting his Dissertation; staying close to family and friends in the area.
URL:https://coe.northeastern.edu/event/chemical-engineering-fall-seminar-series-william-doherty/
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DTSTART;TZID=America/New_York:20251022T133000
DTEND;TZID=America/New_York:20251022T143000
DTSTAMP:20260408T220612
CREATED:20250908T134401Z
LAST-MODIFIED:20251124T145252Z
UID:53319-1761139800-1761143400@coe.northeastern.edu
SUMMARY:Scientific Oral Communication : CommLab Drop-In Workshops
DESCRIPTION:The NU CommLab is hosting a weekly hybrid Scientific Oral Communication Drop-in practice for graduate students. Drop-in virtually or in-person any week to practice for your upcoming oral exams\, proposals\, thesis\, dissertation or talks. Receive and implement feedback on your verbal and non-verbal public speaking skills. Drop-in any Wednesday from 1:30-2:30 pm in 306 Egan or on Zoom. Note on September 10 and October 8 the workshop will be in 334 Curry Student Center.
URL:https://coe.northeastern.edu/event/scientific-oral-communication-commlab-drop-in-workshops-2/2025-10-22/
LOCATION:https://coe.northeastern.edu/event/scientific-oral-communication-commlab-drop-in-workshops-2/2025-10-22/
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