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X-ORIGINAL-URL:https://coe.northeastern.edu
X-WR-CALDESC:Events for Northeastern University College of Engineering
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250504T130000
DTEND;TZID=America/New_York:20250504T150000
DTSTAMP:20260405T062858
CREATED:20250424T135557Z
LAST-MODIFIED:20260302T190956Z
UID:50585-1746363600-1746370800@coe.northeastern.edu
SUMMARY:2025 MGEN Awards Ceremony
DESCRIPTION:Join us as we celebrate the outstanding achievements and dedicated contributions of our students in the MGEN unit. This event will include: \n\nStudent Awards & Recognition\nNetworking & Community Gathering\nLight Refreshments\n\nRSVP \n 
URL:https://coe.northeastern.edu/event/2025-ise-awards-ceremony/
LOCATION:CSC Ballroom\, 360 Huntington Ave\, 2nd fl CSC\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20250506
DTEND;VALUE=DATE:20250508
DTSTAMP:20260405T062858
CREATED:20250127T214315Z
LAST-MODIFIED:20250127T214315Z
UID:48967-1746489600-1746662399@coe.northeastern.edu
SUMMARY:Women in Tech USA
DESCRIPTION:Join the Graduate Admissions team at the Women in Tech USA conference in National Harbor\, MD. Connect with us throughout the event to learn more about our graduate engineering programs offered across the globe\, especially our Arlington\, VA campus!
URL:https://coe.northeastern.edu/event/women-in-tech-usa/
ORGANIZER;CN="Graduate School of Engineering":MAILTO:coe-gradadmissions@northeastern.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250506T100000
DTEND;TZID=America/New_York:20250506T120000
DTSTAMP:20260405T062858
CREATED:20250106T144443Z
LAST-MODIFIED:20250106T144443Z
UID:48187-1746525600-1746532800@coe.northeastern.edu
SUMMARY:Graduate Student Virtual Drop-In Proposal Writing Hours
DESCRIPTION:Graduate students\, are you looking for support in writing your dissertation or research proposal?  Join the CommLab virtual drop-in writing hours any Tuesday between 10 am -12 pm ET and stay for a short time or the whole two hours.  A CommLab Fellow will be available to help you set writing goals and provide feedback on your writing.  We will be meeting weekly on Zoom.
URL:https://coe.northeastern.edu/event/graduate-student-virtual-drop-in-proposal-writing-hours/2025-05-06/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250512T163000
DTEND;TZID=America/New_York:20250512T180000
DTSTAMP:20260405T062858
CREATED:20250207T184252Z
LAST-MODIFIED:20250730T200912Z
UID:49310-1747067400-1747072800@coe.northeastern.edu
SUMMARY:Women in Engineering Book Club
DESCRIPTION:Join the Women in Engineering Book Club! \nWhen: 2nd of Monday of every month at 4:30pm \nWhere: Snell Library’s Research & Teaching Hub (SL 215) \nWhat we are reading: Women in Engineering Book Club – Book List
URL:https://coe.northeastern.edu/event/women-in-engineering-book-club/2025-05-12/
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20250513
DTEND;VALUE=DATE:20250516
DTSTAMP:20260405T062858
CREATED:20250127T214218Z
LAST-MODIFIED:20250127T214218Z
UID:48972-1747094400-1747353599@coe.northeastern.edu
SUMMARY:ODSC East 2025 - Open Data Science Conference
DESCRIPTION:Join the Graduate Admissions team at ODSC East in Boston\, MA to learn about our graduate engineering programs.
URL:https://coe.northeastern.edu/event/odsc-east-2025-open-data-science-conference/
ORGANIZER;CN="Graduate School of Engineering":MAILTO:coe-gradadmissions@northeastern.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250513T130000
DTEND;TZID=America/New_York:20250513T140000
DTSTAMP:20260405T062858
CREATED:20250506T191733Z
LAST-MODIFIED:20250506T191733Z
UID:50755-1747141200-1747144800@coe.northeastern.edu
SUMMARY:Chat with Samantha Johnson: A Northeastern alum changing lives through robotics
DESCRIPTION:Samantha Johnson\, E’20\, MS’21\, returns to Northeastern to share her journey from student to social impact innovator. She’ll discuss the Tatum T1\, a first-of-its-kind robotic hand designed to communicate in tactile American Sign Language for the DeafBlind community. \nThe conversation will highlight how accessible technology\, research\, and entrepreneurship intersect—and how Northeastern experiences helped shape her path. \nThis webinar is open to all. Live captions will be provided. \nSpeakers \n\nFujita\, Akira\nDigital Accessibility SpecialistNortheastern University\nSamantha Johnson\n\nRegister
URL:https://coe.northeastern.edu/event/chat-with-samantha-johnson-a-northeastern-alum-changing-lives-through-robotics/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250514T130000
DTEND;TZID=America/New_York:20250514T140000
DTSTAMP:20260405T062858
CREATED:20250506T190741Z
LAST-MODIFIED:20250506T190741Z
UID:50753-1747227600-1747231200@coe.northeastern.edu
SUMMARY:An Automatic System to Detect Equivalence Between Iterative Algorithms
DESCRIPTION:Institute for Experiential AI Speaker: Laurent Lessard \nLarge-scale optimization problems in machine learning\, signal processing\, multi-agent systems\, and imaging have fueled ongoing interest in iterative optimization algorithms. New optimization algorithms are regularly proposed in order to capture more complicated models\, reduce computational burdens\, or obtain stronger performance and convergence guarantees. But how can we be sure a recently proposed algorithm is novel? Algorithms can be written in different equivalent ways that are not always obvious\, and with optimization being increasingly prevalent across different applications\, popular algorithms are routinely “re-discovered”. In this talk\, we present a framework for reasoning about equivalence of iterative algorithms. Our framework is based on concepts from control theory and linear systems theory and can identify equivalence for a variety of algorithm classes: (a) single-oracle algorithms such as gradient-based methods\, (b) multi-oracle algorithms such as distributed optimization algorithms\, primal-dual methods\, and operator-splitting methods\, and (c) algorithms that use different but related oracles\, such as subdifferentials\, proximal operators\, and Fenchel conjugates. Our work is a promising step towards an integrated and principled methodology for analyzing and designing control systems that use optimization algorithms “in the loop”. \nLocation: Teams \nRegister
URL:https://coe.northeastern.edu/event/an-automatic-system-to-detect-equivalence-between-iterative-algorithms/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250516T090000
DTEND;TZID=America/New_York:20250516T180000
DTSTAMP:20260405T062858
CREATED:20250403T200554Z
LAST-MODIFIED:20250407T144203Z
UID:50326-1747386000-1747418400@coe.northeastern.edu
SUMMARY:IEEE-Sensors-In-Spotlight
DESCRIPTION:IEEE-Sensors-In-Spotlight is a unique one-day networking event introducing emerging applications that will inspire technological developments in years to come. The event will take place on Friday\, May 16\, 2025\, at the Interdisciplinary Science and Engineering Complex\, 805 Columbus Ave.\, Boston\, MA from 9:00am-6:00pm EST. Sensors in Spotlight is where sensor technologies take the central stage. The program includes keynote speaker presentations\, panel discussions\, poster and live demo session\, and plenty of networking opportunities. The event will inform and inspire creation of a technological eco-system in support of BIG VISIONS. The committee encourages all students\, both undergraduate and graduate\, under the College of Engineering to submit their abstract and present their posters during the conference. The best poster award will receive a $250 prize. The deadline to submit your poster is on Wednesday\, April 30\, 2025. Please submit your poster by visiting Call for Posters | SenSiS 2025 – Boston\, Massachusetts.
URL:https://coe.northeastern.edu/event/ieee-sensors-in-spotlight/
LOCATION:102 ISEC\, 360 Huntington Ave\, 102 ISEC\, Boston\, MA\, 02115\, United States
GEO:42.3377335;-71.0869121
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250517T100000
DTEND;TZID=America/New_York:20250517T140000
DTSTAMP:20260405T062858
CREATED:20250414T133822Z
LAST-MODIFIED:20250414T133822Z
UID:50450-1747476000-1747490400@coe.northeastern.edu
SUMMARY:COE in Latin America (Brazil)
DESCRIPTION:You are cordially invited to Northeastern University’s Global Study Expo in Brazil. \nThis in-person event is your opportunity to: \n\nConnect with Northeastern representatives from a variety of our colleges and campuses\, and get personalized help with your application.\nLearn more about Northeastern’s degree programs and admissions requirements.\nDiscover various scholarship opportunities.\nHear about the benefits of our global campus network\, with locations in the U.S.\, the U.K.\, and Canada.\nListen to alumni discuss their academic and career experiences.\nExplore co-ops and other experience-based learning opportunities.\n\nThis is your chance to meet in person with staff\, alumni\, and other representatives and find answers to all your questions. \nLooking forward to seeing you there! \nEvent Details: \n\nBrazil:\n\nSaturday\, May 17\, 2025\n10 a.m. to 2 p.m. BRT\nVenue: Tivoli Mofarrej São Paulo Hotel
URL:https://coe.northeastern.edu/event/coe-in-latin-america-brazil/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250527T090000
DTEND;TZID=America/New_York:20250527T110000
DTSTAMP:20260405T062858
CREATED:20250529T202413Z
LAST-MODIFIED:20250529T202413Z
UID:51017-1748336400-1748343600@coe.northeastern.edu
SUMMARY:Graduate Student Writing:  CommLab Drop-In Writing Hours
DESCRIPTION:Graduate students\, are you looking for a time for focused research writing?  Join the CommLab drop-in writing hours any Tuesday between 9 -11 am ET.  Drop in any Tuesday and stay for a short time or two hours.  A CommLab Fellow will be available to provide feedback on your writing.  We will be meeting virtually on Teams.
URL:https://coe.northeastern.edu/event/graduate-student-writing-commlab-drop-in-writing-hours/2025-05-27/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250527T100000
DTEND;TZID=America/New_York:20250527T120000
DTSTAMP:20260405T062858
CREATED:20250529T202128Z
LAST-MODIFIED:20250529T202128Z
UID:51056-1748340000-1748347200@coe.northeastern.edu
SUMMARY:Graduate Student Proposal/Fellowship Writing Hours: CommLab Drop-In Hours
DESCRIPTION:Graduate students\, are you looking for support in writing your research or fellowship proposal?  Join the CommLab virtual drop-in writing hours any Tuesday between 10 am -12 pm ET and stay for a short time or the whole two hours.  A CommLab Fellow will be available to help you set writing goals and provide feedback on your writing.  Join this drop-in workshop through Zoom.
URL:https://coe.northeastern.edu/event/graduate-student-proposal-fellowship-writing-hours-commlab-drop-in-hours/2025-05-27/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250528T130000
DTEND;TZID=America/New_York:20250528T140000
DTSTAMP:20260405T062858
CREATED:20250529T201707Z
LAST-MODIFIED:20250529T201707Z
UID:51074-1748437200-1748440800@coe.northeastern.edu
SUMMARY:Scientific Oral Communication : CommLab Drop-In Workshops
DESCRIPTION:The NU CommLab is hosting a weekly hybrid Scientific Oral Communication Drop-in practice for graduate students. Drop-in virtually or in-person any week to practice for your upcoming oral exams\, proposals\, thesis\, dissertation or talks. Receive and implement feedback on your verbal and non-verbal public speaking skills. Meet any Wednesday from 1-2pm in 306 Egan or on Zoom. Note on June 4th the workshop will be in 206 Egan.
URL:https://coe.northeastern.edu/event/scientific-oral-communication-commlab-drop-in-workshops/2025-05-28/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250603T090000
DTEND;TZID=America/New_York:20250603T110000
DTSTAMP:20260405T062858
CREATED:20250529T202413Z
LAST-MODIFIED:20250529T202413Z
UID:51018-1748941200-1748948400@coe.northeastern.edu
SUMMARY:Graduate Student Writing:  CommLab Drop-In Writing Hours
DESCRIPTION:Graduate students\, are you looking for a time for focused research writing?  Join the CommLab drop-in writing hours any Tuesday between 9 -11 am ET.  Drop in any Tuesday and stay for a short time or two hours.  A CommLab Fellow will be available to provide feedback on your writing.  We will be meeting virtually on Teams.
URL:https://coe.northeastern.edu/event/graduate-student-writing-commlab-drop-in-writing-hours/2025-06-03/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250603T100000
DTEND;TZID=America/New_York:20250603T120000
DTSTAMP:20260405T062858
CREATED:20250529T202128Z
LAST-MODIFIED:20250529T202128Z
UID:51057-1748944800-1748952000@coe.northeastern.edu
SUMMARY:Graduate Student Proposal/Fellowship Writing Hours: CommLab Drop-In Hours
DESCRIPTION:Graduate students\, are you looking for support in writing your research or fellowship proposal?  Join the CommLab virtual drop-in writing hours any Tuesday between 10 am -12 pm ET and stay for a short time or the whole two hours.  A CommLab Fellow will be available to help you set writing goals and provide feedback on your writing.  Join this drop-in workshop through Zoom.
URL:https://coe.northeastern.edu/event/graduate-student-proposal-fellowship-writing-hours-commlab-drop-in-hours/2025-06-03/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250603T110000
DTEND;TZID=America/New_York:20250603T120000
DTSTAMP:20260405T062858
CREATED:20250529T202325Z
LAST-MODIFIED:20250715T141410Z
UID:51032-1748948400-1748952000@coe.northeastern.edu
SUMMARY:LinkedIn\, CV\, Resume: CommLab Drop-In Hours
DESCRIPTION:Graduate students\, do you need to increase your on-line presence or update your CV or Resume?  Join the CommLab’s LinkedIn\, CV\, and Resume drop-in workshops every other Tuesday from 11 pm to 12 pm ET. This collaborative space offers valuable advice and peer feedback to enhance your online profile and professional presence. Join this drop-in workshop through Zoom.
URL:https://coe.northeastern.edu/event/linkedin-cv-resume-commlab-drop-in-hours/2025-06-03/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250604T130000
DTEND;TZID=America/New_York:20250604T140000
DTSTAMP:20260405T062858
CREATED:20250529T201707Z
LAST-MODIFIED:20250529T201707Z
UID:51075-1749042000-1749045600@coe.northeastern.edu
SUMMARY:Scientific Oral Communication : CommLab Drop-In Workshops
DESCRIPTION:The NU CommLab is hosting a weekly hybrid Scientific Oral Communication Drop-in practice for graduate students. Drop-in virtually or in-person any week to practice for your upcoming oral exams\, proposals\, thesis\, dissertation or talks. Receive and implement feedback on your verbal and non-verbal public speaking skills. Meet any Wednesday from 1-2pm in 306 Egan or on Zoom. Note on June 4th the workshop will be in 206 Egan.
URL:https://coe.northeastern.edu/event/scientific-oral-communication-commlab-drop-in-workshops/2025-06-04/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250604T143000
DTEND;TZID=America/New_York:20250604T153000
DTSTAMP:20260405T062858
CREATED:20250520T170027Z
LAST-MODIFIED:20250520T170027Z
UID:50920-1749047400-1749051000@coe.northeastern.edu
SUMMARY:COE Outlook Live Q&A Sessions
DESCRIPTION:Northeastern is migrating all College of Engineering email accounts to Microsoft Outlook. Attend these live Q&A sessions where you can feel free to ask the Engineering Computer Center any questions you may have about the current email migration to Outlook. \nSession 1\nWednesday\, June 4\n11:30-12:30 PT / 2:30-3:30 p.m. ET / 7:30-8:30 p.m. GT\nJoin the Q&A via Teams > \nSession 2\nWednesday\, June 11\n11:30-12:30 PT / 2:30-3:30 p.m. ET / 7:30-8:30 p.m. GT\nJoin the Q&A via Teams >
URL:https://coe.northeastern.edu/event/coe-outlook-live-qa-sessions/2025-06-04/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250605T100000
DTEND;TZID=America/New_York:20250605T120000
DTSTAMP:20260405T062858
CREATED:20250604T183853Z
LAST-MODIFIED:20250604T183853Z
UID:51182-1749117600-1749124800@coe.northeastern.edu
SUMMARY:ChE PhD Dissertation Defense: Victoria Duback
DESCRIPTION:Name:\nVictoria Duback \nTitle:\nPharmacokinetic and Pharmacodynamic Assessment of a T Cell-Targeted Vector for In Vivo Car-T Cell Therapy \nDate:\n06/05/2024 \nTime:\n10:00:00 AM \nCommittee Members:\nProf. Abigail Koppes (Advisor)\nProf. Ryan Koppes\nProf. Debra Auguste\nDr. Kutlu Elpek \nLocation:\nKariotis 309 \nAbstract:\nChimeric antigen receptor (CAR) T-cell therapy has demonstrated transformative efficacy in the treatment of B-cell malignancies\, particularly through autologous approaches. However\, the clinical utility of autologous CAR-T therapy is limited by complex manufacturing processes\, patient-specific variability\, and the requirement for lymphodepletion\, which can delay or prevent treatment for critically ill patients. In vivo-generated CAR-T cell therapy offers a promising alternative by enabling the direct genetic engineering of T cells within the patient\, potentially streamlining treatment and expanding access. \nThis dissertation focuses on the preclinical characterization of a CD8-targeted lentiviral fusosome designed to deliver a CD19-specific CAR transgene in vivo. The overarching objective of this work is to understand the relationship between the pharmacokinetics (PK) and pharmacodynamics (PD) of in vivo CAR-T cell generation to inform the development and clinical translation of nextgeneration gene therapy products. In vitro experiments demonstrated efficient and selective transduction of both resting and pre-activated CD8⁺ T cells\, with enhanced CAR expression and function in pre-activated populations. A humanized mouse model was optimized to evaluate vector performance in vivo\, incorporating engraftment of human PBMCs and CD19⁺ tumor cells to assess efficacy\, biodistribution\, and dose-response relationships. \nPharmacokinetic studies revealed rapid clearance of the vector in naïve mice\, while the presence of target T cells significantly prolonged vector persistence\, likely through cellular binding and internalization. Dose-dependent CAR-T cell generation and tumor suppression were observed\, with no signs of fusosome-related toxicity. Importantly\, donor-to-donor variability was noted\, emphasizing the need for robust model systems in predicting clinical outcomes. To further enhance the fusosome potency\, novel constructs incorporating CD3-mediated activation signals were engineered\, resulting in improved gene integration and functional CAR-T activity in vitro. Together\, these studies provide critical insight into the PK/PD relationship of in vivo CAR-T cell therapies and establish a strong preclinical foundation for the continued development of clinically viable\, targeted lentiviral vectors for the treatment of B cell malignancies. \n\n \nVictoria (Tori) Duback is a third-year doctoral candidate in the Chemical Engineering department at Northeastern University\, pursuing a Ph.D. in Engineering with a focus on viral vector gene delivery. She is expected to graduate in June 2025. Her research focuses on characterizing targeted gene delivery systems\, and her thesis examines the pharmacokinetics and pharmacodynamics of a T-cell-targeted vector for the treatment of B-cell malignancies. In parallel with her academic pursuits\, Tori is a seasoned industry professional\, serving as a Senior Scientist at Sana Biotechnology in the T-cell therapeutics group. Over the past several years\, she has played a pivotal role in the design and evaluation of cutting-edge immunotherapies. She leads a team of scientists dedicated to assessing the safety and efficacy of in vivo generated CAR-T cells and allogeneic CAR-T cell therapies\, conducting studies both in vivo and in vitro. Beyond the lab\, Tori is a passionate advocate for STEM education and community engagement. She has mentored high school students across the Boston Public Schools\, promoting early exposure to careers in science and engineering. Her commitment to mentoring and education reflects her belief in creating more inclusive and accessible pathways into scientific research. Looking ahead\, she aims to continue growing as a scientist in industry\, with a focus on developing safe\, effective\, and accessible therapies for patients in need. In her free time\, Tori enjoys traveling\, outdoor activities\, and spending time at the beach.
URL:https://coe.northeastern.edu/event/che-phd-dissertation-defense-victoria-duback/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250605T150000
DTEND;TZID=America/New_York:20250605T160000
DTSTAMP:20260405T062858
CREATED:20250529T201946Z
LAST-MODIFIED:20250529T201946Z
UID:51071-1749135600-1749139200@coe.northeastern.edu
SUMMARY:Poster Design and Presentation: CommLab Drop-In Workshops
DESCRIPTION:Working on a poster? Stop by this two-part CommLab hybrid workshop!  Part 1 will focus on brainstorming ideas\, getting feedback and fine tuning the visual presentation of your research and Part 2 will enable you to practice your poster oral presentation and get feedback. Thursday June 5 and 12 from 3-4pm EST in room 206 Egan or join virtually on Zoom.  Want more feedback?  Join the on-line Zoom feedback sessions on Tuesdays\, June\, 3\, 10 and 17 from 1-2pm ET.
URL:https://coe.northeastern.edu/event/poster-design-and-presentation-commlab-drop-in-workshops-2/2025-06-05/
LOCATION:206 Egan\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
GEO:42.3376753;-71.0888734
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=206 Egan 360 Huntington Ave Boston MA 02115 United States;X-APPLE-RADIUS=500;X-TITLE=360 Huntington Ave:geo:-71.0888734,42.3376753
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250609T140000
DTEND;TZID=America/New_York:20250609T160000
DTSTAMP:20260405T062858
CREATED:20250604T183743Z
LAST-MODIFIED:20250604T183743Z
UID:51188-1749477600-1749484800@coe.northeastern.edu
SUMMARY:ChE PhD Dissertation Defense: Matthew Fernez
DESCRIPTION:Name:\nMatthew Fernez \nTitle:\nDevelopment of a Hydrogen Sulfide Biosensor and Interrogation the Role of Sulfide on Mucus Barriers \nDate:\n06/05/2024 \nTime:\n10:00:00 AM \nCommittee Members:\nProf. Benjamin Woolston (Advisor)\nProf. Rebecca Carrier (Co-Advisor)\nProf. Erel Levine\nDr. Jodie Ouahed \nLocation:\nShillman 420 \nAbstract:\nInflammatory bowel disease (IBD) is a gastrointestinal condition that is estimated to afflict more than 1% of adults\, with prevalence increasing over time. Hydrogen sulfide (H2S)\, produced by the gut microbiota and partially by the host epithelium\, has long been associated with IBD through metagenomic evidence of increased populations of sulfate producing bacteria in patients. However\, the effects of sulfide are disputed and the mechanisms underlying disease pathogenesis remain unresolved. Sulfide literature suggests both a therapeutic and restorative effect at low levels yet also implies higher levels may be toxic\, resulting in disruption of mucus barriers and promotion of an inflammatory cascade. The mucus barrier is comprised of a mucin network crosslinked by disulfide bonds\, along with myriad heterogenous components\, which provides protection for the cell lining from the microbiota and toxic byproducts. We hypothesize that in excess\, sulfide reduces disulfide bonds yielding a weaker\, more permeable barrier that is susceptible to microbial penetration. However\, studying sulfide in the gut microenvironment is technically challenging due to its high volatility and reactivity\, making accurate GI measurements challenging in vivo. Here\, we seek to address measurement limitations through the development of a sulfide biosensor and evaluate the impacts of sulfide on mucus barriers. \nThis thesis has three core elements: optimization of a functional sulfide biosensor\, exploration of implementation in a mesofluidic gut-on-chip\, and direct evaluation of sulfide on mucus barrier properties. To construct a transcriptional sulfide biosensor\, a polysulfide sensitive repressor\, SqrR\, from Rhodobacter capsulatus was codon harmonized and inserted into a plasmid with a fluorescent reporter module driven by the SqrR affiliated promoter pSqr. To convert sulfide into polysufides that de-activate SqrR\, we coupled the sensing plasmid with an enzymatic plasmid bearing codon harmonized Sqr from R. capsulatus. Initial construction failed to generate a response to sulfide\, but an 18-fold dynamic range up to 750 M in aerobic conditions was produced through pSqr engineering and SqrR tagging and titration. Sqr activity and products were characterized\, but failed to generate a response under anaerobic conditions likely due to electron transport chain dependent quinone incompatibility. Given that the gut microenvironment is largely anaerobic\, sensor response under anaerobic conditions was recovered through isolation of a novel Sqr homolog from Wolinella succinogenes\, an organism that couples sulfide oxidation to reduction of fumarate\, a compound abundant in the gut. We demonstrate sensor activity under anoxic conditions using this enzyme with both fumarate and nitrate\, a marker of the inflamed gut. The group has previously developed a gut on chip PDMS device with vertical orientation for cross sectional imaging of the mucus barrier of primary intestinal epithelium under static conditions. The gas permeability of PDMS encouraged us to attempt gel wall modifications to permit consistent delivery of sulfide via flow. While modifications of the gut chip to operate under continuous flow culture were unsuccessful\, a simple demonstration of a partial response to sulfide by the biosensor on chip is presented in the absence of epithelium\, illustrating promise for implementation as a diagnostic in the future. Finally\, the impacts of sulfide on mucus were elucidated in the third part of the thesis. Using harvested porcine intestinal mucus (PIM)\, we demonstrate that diffusivity of polystyrene nanoparticles in PIM increases 1.6 fold when treated with 1 mM sulfide. Sulfide also impacted microbial velocity and motion type\, yielding a statistically significant increase of average velocity and proportion of microbes exhibiting penetration like behavior. While structural changes were not observed through lectin staining of PIM\, the thesis culminates in a simple demonstration of deleterious effects of sulfide on a living mucus barrier in our gut on chip system. Mucus thickness was reduced and resulted in an increased proportion of nanoparticles that penetrated the mucus barrier. Taken together\, this work produced a novel sulfide biosensor that functions under aerobic and anaerobic conditions and characterized the deleterious effects of sulfide on barrier permeability suspected by the underlying hypothesis of reduction of disulfide bonds in mucus structure. \n\n \nMatt Fernez is currently a sixth year PhD student in Chemical Engineering at Northeastern University. He completed a Bachelor of Science in Chemical Engineering in May\, 2019 at University of Massachusetts Amherst where he also produced an honors thesis. In June of this year\, he will defend his PhD Thesis to complete the doctoral degree. His research is co-advised and focuses on synthetic biology and tissue engineering\, with the focus of studying mucus barrier properties utilizing genetically engineered bacteria. His dissertation is titled “Development of a Hydrogen Sulfide Biosensor and Interrogation the Role of Sulfide on Mucus Barriers”. He has contributed towards authorship on 4 publications\, including one review paper and three technical papers. His first author sulfide biosensor manuscript was recently published in ACS Synthetic Biology in Spring\, 2025. His research has been presented at 4 conferences\, culminating in an oral presentation at the American Institute of Chemical Engineering international conference in October\, 2024. He has been a mentor to several undergraduate students who have produced research posters at Northeastern’s undergraduate research conference. He also assisted in building the foundation of the now well-established Woolston Lab\, being one of the first two students and serving as the Lab Safety Officer. Outside of research\, Matt has many recreational hobbies including poker\, hiking\, travelling\, and fantasy sports. He is the president and founder of a local poker club in the greater Boston area. He also enjoys spending time with family and writing poetry.
URL:https://coe.northeastern.edu/event/che-phd-dissertation-defense-matthew-fernez/
LOCATION:420 Shillman Hall\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
GEO:42.3396156;-71.0886534
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=420 Shillman Hall 360 Huntington Ave Boston MA 02115 United States;X-APPLE-RADIUS=500;X-TITLE=360 Huntington Ave:geo:-71.0886534,42.3396156
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250609T163000
DTEND;TZID=America/New_York:20250609T180000
DTSTAMP:20260405T062858
CREATED:20250207T184252Z
LAST-MODIFIED:20250730T200912Z
UID:49311-1749486600-1749492000@coe.northeastern.edu
SUMMARY:Women in Engineering Book Club
DESCRIPTION:Join the Women in Engineering Book Club! \nWhen: 2nd of Monday of every month at 4:30pm \nWhere: Snell Library’s Research & Teaching Hub (SL 215) \nWhat we are reading: Women in Engineering Book Club – Book List
URL:https://coe.northeastern.edu/event/women-in-engineering-book-club/2025-06-09/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250610T090000
DTEND;TZID=America/New_York:20250610T110000
DTSTAMP:20260405T062858
CREATED:20250529T202414Z
LAST-MODIFIED:20250529T202414Z
UID:51019-1749546000-1749553200@coe.northeastern.edu
SUMMARY:Graduate Student Writing:  CommLab Drop-In Writing Hours
DESCRIPTION:Graduate students\, are you looking for a time for focused research writing?  Join the CommLab drop-in writing hours any Tuesday between 9 -11 am ET.  Drop in any Tuesday and stay for a short time or two hours.  A CommLab Fellow will be available to provide feedback on your writing.  We will be meeting virtually on Teams.
URL:https://coe.northeastern.edu/event/graduate-student-writing-commlab-drop-in-writing-hours/2025-06-10/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250610T100000
DTEND;TZID=America/New_York:20250610T120000
DTSTAMP:20260405T062858
CREATED:20250529T202129Z
LAST-MODIFIED:20250529T202129Z
UID:51058-1749549600-1749556800@coe.northeastern.edu
SUMMARY:Graduate Student Proposal/Fellowship Writing Hours: CommLab Drop-In Hours
DESCRIPTION:Graduate students\, are you looking for support in writing your research or fellowship proposal?  Join the CommLab virtual drop-in writing hours any Tuesday between 10 am -12 pm ET and stay for a short time or the whole two hours.  A CommLab Fellow will be available to help you set writing goals and provide feedback on your writing.  Join this drop-in workshop through Zoom.
URL:https://coe.northeastern.edu/event/graduate-student-proposal-fellowship-writing-hours-commlab-drop-in-hours/2025-06-10/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250610T110000
DTEND;TZID=America/New_York:20250610T120000
DTSTAMP:20260405T062858
CREATED:20250529T202325Z
LAST-MODIFIED:20250529T202325Z
UID:52658-1749553200-1749556800@coe.northeastern.edu
SUMMARY:LinkedIn\, CV\, Resume: CommLab Drop-In Hours
DESCRIPTION:Graduate students\, do you need to increase your on-line presence or update your CV or Resume?  Join the CommLab’s LinkedIn\, CV\, and Resume drop-in workshops every other Tuesday from 11 pm to 12 pm ET. This collaborative space offers valuable advice and peer feedback to enhance your online profile and professional presence. Join this drop-in workshop through Zoom.
URL:https://coe.northeastern.edu/event/linkedin-cv-resume-commlab-drop-in-hours/2025-06-10/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250611T130000
DTEND;TZID=America/New_York:20250611T140000
DTSTAMP:20260405T062858
CREATED:20250529T201708Z
LAST-MODIFIED:20250529T201708Z
UID:51076-1749646800-1749650400@coe.northeastern.edu
SUMMARY:Scientific Oral Communication : CommLab Drop-In Workshops
DESCRIPTION:The NU CommLab is hosting a weekly hybrid Scientific Oral Communication Drop-in practice for graduate students. Drop-in virtually or in-person any week to practice for your upcoming oral exams\, proposals\, thesis\, dissertation or talks. Receive and implement feedback on your verbal and non-verbal public speaking skills. Meet any Wednesday from 1-2pm in 306 Egan or on Zoom. Note on June 4th the workshop will be in 206 Egan.
URL:https://coe.northeastern.edu/event/scientific-oral-communication-commlab-drop-in-workshops/2025-06-11/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250611T143000
DTEND;TZID=America/New_York:20250611T153000
DTSTAMP:20260405T062858
CREATED:20250520T170027Z
LAST-MODIFIED:20250520T170027Z
UID:50921-1749652200-1749655800@coe.northeastern.edu
SUMMARY:COE Outlook Live Q&A Sessions
DESCRIPTION:Northeastern is migrating all College of Engineering email accounts to Microsoft Outlook. Attend these live Q&A sessions where you can feel free to ask the Engineering Computer Center any questions you may have about the current email migration to Outlook. \nSession 1\nWednesday\, June 4\n11:30-12:30 PT / 2:30-3:30 p.m. ET / 7:30-8:30 p.m. GT\nJoin the Q&A via Teams > \nSession 2\nWednesday\, June 11\n11:30-12:30 PT / 2:30-3:30 p.m. ET / 7:30-8:30 p.m. GT\nJoin the Q&A via Teams >
URL:https://coe.northeastern.edu/event/coe-outlook-live-qa-sessions/2025-06-11/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250612T150000
DTEND;TZID=America/New_York:20250612T160000
DTSTAMP:20260405T062858
CREATED:20250529T201946Z
LAST-MODIFIED:20250529T201946Z
UID:51072-1749740400-1749744000@coe.northeastern.edu
SUMMARY:Poster Design and Presentation: CommLab Drop-In Workshops
DESCRIPTION:Working on a poster? Stop by this two-part CommLab hybrid workshop!  Part 1 will focus on brainstorming ideas\, getting feedback and fine tuning the visual presentation of your research and Part 2 will enable you to practice your poster oral presentation and get feedback. Thursday June 5 and 12 from 3-4pm EST in room 206 Egan or join virtually on Zoom.  Want more feedback?  Join the on-line Zoom feedback sessions on Tuesdays\, June\, 3\, 10 and 17 from 1-2pm ET.
URL:https://coe.northeastern.edu/event/poster-design-and-presentation-commlab-drop-in-workshops-2/2025-06-12/
LOCATION:206 Egan\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
GEO:42.3376753;-71.0888734
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=206 Egan 360 Huntington Ave Boston MA 02115 United States;X-APPLE-RADIUS=500;X-TITLE=360 Huntington Ave:geo:-71.0888734,42.3376753
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250617T090000
DTEND;TZID=America/New_York:20250617T110000
DTSTAMP:20260405T062858
CREATED:20250529T202414Z
LAST-MODIFIED:20250529T202414Z
UID:51020-1750150800-1750158000@coe.northeastern.edu
SUMMARY:Graduate Student Writing:  CommLab Drop-In Writing Hours
DESCRIPTION:Graduate students\, are you looking for a time for focused research writing?  Join the CommLab drop-in writing hours any Tuesday between 9 -11 am ET.  Drop in any Tuesday and stay for a short time or two hours.  A CommLab Fellow will be available to provide feedback on your writing.  We will be meeting virtually on Teams.
URL:https://coe.northeastern.edu/event/graduate-student-writing-commlab-drop-in-writing-hours/2025-06-17/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250617T100000
DTEND;TZID=America/New_York:20250617T120000
DTSTAMP:20260405T062858
CREATED:20250529T202129Z
LAST-MODIFIED:20250529T202129Z
UID:51059-1750154400-1750161600@coe.northeastern.edu
SUMMARY:Graduate Student Proposal/Fellowship Writing Hours: CommLab Drop-In Hours
DESCRIPTION:Graduate students\, are you looking for support in writing your research or fellowship proposal?  Join the CommLab virtual drop-in writing hours any Tuesday between 10 am -12 pm ET and stay for a short time or the whole two hours.  A CommLab Fellow will be available to help you set writing goals and provide feedback on your writing.  Join this drop-in workshop through Zoom.
URL:https://coe.northeastern.edu/event/graduate-student-proposal-fellowship-writing-hours-commlab-drop-in-hours/2025-06-17/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250617T110000
DTEND;TZID=America/New_York:20250617T120000
DTSTAMP:20260405T062858
CREATED:20250529T202325Z
LAST-MODIFIED:20250715T141412Z
UID:51203-1750158000-1750161600@coe.northeastern.edu
SUMMARY:LinkedIn\, CV\, Resume: CommLab Drop-In Hours
DESCRIPTION:Graduate students\, do you need to increase your on-line presence or update your CV or Resume?  Join the CommLab’s LinkedIn\, CV\, and Resume drop-in workshops every other Tuesday from 11 pm to 12 pm ET. This collaborative space offers valuable advice and peer feedback to enhance your online profile and professional presence. Join this drop-in workshop through Zoom.
URL:https://coe.northeastern.edu/event/linkedin-cv-resume-commlab-drop-in-hours/2025-06-17/
END:VEVENT
END:VCALENDAR