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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241202T110000
DTEND;TZID=America/New_York:20241202T130000
DTSTAMP:20260412T234704
CREATED:20241120T203019Z
LAST-MODIFIED:20241120T203019Z
UID:47868-1733137200-1733144400@coe.northeastern.edu
SUMMARY:ChE PhD Dissertation Defense: Changyu Wang
DESCRIPTION:Name: Changyu Wang \nTitle: Surface Engineered Porous Geopolymer to Remove Anionic Contaminants in Water \nDate: 12/02/2024 \nTime: 11:15:00 AM \nCommittee Members:\nProf. Ming Su (Advisor)\nProf. Sara Hashmi\nProf. Kai-Tak Wan\nProf. Qing Zhao \nLocation:\nEXP 610 and Teams \nAbstract:\nGeopolymers are inorganic polymers synthesized from aluminosilicate sources and alkali. They have good nanoporosity and are suitable for adsorption processes in water treatment. This research project aimed to create a hierarchical porous structure within the geopolymer monolith to facilitate the use of inner nanoporosity and modify the porous geopolymer to remove anionic contaminants from water. \nThe porous structure is adjusted by controlling the geopolymerization and foaming process using a pourable geopolymer slurry. Geopolymerization is controlled by temperature and active ingredients in the formulation to have optimal pot life. Sufficient pot life of the slurry is critical to form pores of the desired amount and size. With the aid of appropriate surfactants and foaming agents\, a uniform\, interconnected macroporous structure forms within the geopolymer. This process creates porous monoliths with any desired shape. \nA post-modification process is accomplished by using iron salt solutions with sufficient concentration and appropriate pH. Unmodified and modified geopolymers were characterized by gas adsorption analyzer\, SEM/EDS\, XRD\, and FTIR\, indicating that nano iron oxyhydroxide is incorporated within and changes the porous geopolymer structure. The BET surface area increases from 31 m2/g to 224 m2/g; Micropores and mesopores become dominant nanopores instead of macropores. SEM\, gas adsorption isotherm\, and capillary flow porometry verify that the modified geopolymers have a hierarchical\, interconnected porous structure ranging from half a millimeter to less than two nanometers. The high specific surface area and positively charged iron oxyhydroxide on the porous geopolymer make it an excellent adsorbent to attract anionic contaminants through adsorption. During water treatment\, the macropores act as conduits for the adsorbate in water to contact the interior surface\, and adsorption of contaminants takes place in micropores and smaller mesopores. The modified porous geopolymer was shown to be effective in removing phosphate and rose bengal (an anionic dye with similar adsorption properties to PFAS). After saturation\, the media can be regenerated using sodium hydroxide solution and reused multiple times.
URL:https://coe.northeastern.edu/event/che-phd-dissertation-defense-changyu-wang/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241203T180000
DTEND;TZID=America/New_York:20241203T200000
DTSTAMP:20260412T234704
CREATED:20241121T181106Z
LAST-MODIFIED:20241121T181106Z
UID:47639-1733248800-1733256000@coe.northeastern.edu
SUMMARY:EngGAP Graduate School Collaborative Webinar: Grad 101
DESCRIPTION:Are you a freshman or sophomore interested in graduate school? Then join the COE Graduate Admissions team as part of the EngGAP Graduate School Collaborative to learn how to prepare and be competitive for graduate school! Hear from some of the top Engineering Graduate Programs in the country and then join a breakout session to ask your school of interest more detailed questions.
URL:https://coe.northeastern.edu/event/enggap-graduate-school-collaborative-webinar-grad-101/
ORGANIZER;CN="Graduate School of Engineering":MAILTO:coe-gradadmissions@northeastern.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241204T090000
DTEND;TZID=America/New_York:20241204T110000
DTSTAMP:20260412T234704
CREATED:20240830T155557Z
LAST-MODIFIED:20241122T164831Z
UID:45487-1733302800-1733310000@coe.northeastern.edu
SUMMARY:Graduate Student Drop-In Writing Hours
DESCRIPTION:Graduate students\, are you looking for a place for focused research writing time?  Join the CommLab drop-in writing hours any Wednesday between 9 -11 am ET.  Drop in any Wednesday and stay for a short time or two hours.  A CommLab Fellow will also be available to provide feedback on your writing.  We will be meeting in weekly in 334 Curry Student Center.  Note we will meet in 336 Curry Student Center on Wednesday\, September 25th.
URL:https://coe.northeastern.edu/event/graduate-student-drop-in-writing-hours/2024-12-04/
LOCATION:Curry Student Center\, 360 Huntington Ave.\, Boston\, MA\, 02115\, United States
GEO:42.3394629;-71.0885286
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Curry Student Center 360 Huntington Ave. Boston MA 02115 United States;X-APPLE-RADIUS=500;X-TITLE=360 Huntington Ave.:geo:-71.0885286,42.3394629
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241204T090000
DTEND;TZID=America/New_York:20241204T170000
DTSTAMP:20260412T234704
CREATED:20241107T153049Z
LAST-MODIFIED:20241115T192142Z
UID:47722-1733302800-1733331600@coe.northeastern.edu
SUMMARY:COE WIE Students Meet-Up
DESCRIPTION:Join us for an all-day office hour session to discuss creating a welcoming environment for female-identifying students in COE. Drop by for coffee\, conversation\, and to share any questions\, concerns\, or suggestions for the next semester. \nDate: December 4th\nTime: All day (9am-5pm)\nLocation: ISEC 5th Floor Common Area
URL:https://coe.northeastern.edu/event/coe-wie-graduate-students-meet-up/
LOCATION:Interdisciplinary Science and Engineering Complex (ISEC)\, 805 Columbus Ave\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241204T120000
DTEND;TZID=America/New_York:20241204T120000
DTSTAMP:20260412T234704
CREATED:20240906T202233Z
LAST-MODIFIED:20240906T203835Z
UID:45661-1733313600-1733313600@coe.northeastern.edu
SUMMARY:Bioengineering Fall Seminar Series
DESCRIPTION:Wednesdays 12-1pm in 105 Shillman Hall\, unless otherwise stated. All are welcome.  \nSpeakers\n\n9/6: Sara Rouhanifard\, PhD\nAssistant Professor of Bioengineering at Northeastern University\n9/11: Mingyang Lu\, PhD\nAssistant Professor of Bioengineering at Northeastern University\n9/18: Joanna Dahl\, PhD\nAssistant Professor of Engineering at the University of Massachusetts Boston \n9/25: Stirling Churchman\, PhD\nProfessor of Genetics at Harvard Medical School\n10/2: Sujit Datta\, PhD *in collaboration with CHME*\nProfessor of Chemical Engineering\, Bioengineering and Biophysics at California Institute of Technology\n10/9: Yizeng Li\, PhD\nAssistant Professor of Biomedical Engineering\, Binghamton University \n10/16: Song Li\, PhD\nChancellor’s Professor and Department Chair of Bioengineering at \nthe University of California Los Angeles\n10/23: Seemantini Nadkarni\, PhD\nAssociate Professor of Dermatology at Harvard Medical School \n10/30: None\n11/6: Ramkumar “Ram” Annamalai\, PhD\nAssistant Professor of Biomedical Engineering at the University at Buffalo\n11/13: \nNone\n11/20: Lingchong You\, PhD\nJames L. Meriam Distinguished Professor of Biomedical Engineering and the Director of the Center for Quantitative Biodesign at Duke University\n11/27: \nNone\, Thanksgiving\n12/4: Jeffrey Moffit\, PhD\nAssistant Professor in Microbiology at Harvard Medical School\n11/6: Jeffrey Fredberg\, PhD\, *Friday*\nProfessor of Bioengineering and Physiology at Harvard School for Public Health
URL:https://coe.northeastern.edu/event/bioengineering-fall-seminar-series-2/2024-12-04/
LOCATION:105 Shillman Hall\, 360 Huntington Ave\, 105 SH\, Boston\, MA\, 02115\, United States
ORGANIZER;CN="Bioengineering":MAILTO:bioe@northeastern.edu
GEO:42.337539275041;-71.090062487079
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=105 Shillman Hall 360 Huntington Ave 105 SH Boston MA 02115 United States;X-APPLE-RADIUS=500;X-TITLE=360 Huntington Ave\, 105 SH:geo:-71.090062487079,42.337539275041
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241204T120000
DTEND;TZID=America/New_York:20241204T130000
DTSTAMP:20260412T234704
CREATED:20240806T171609Z
LAST-MODIFIED:20241101T145914Z
UID:44881-1733313600-1733317200@coe.northeastern.edu
SUMMARY:Chemical Engineering Fall Seminar Series: Omokolade Adebowale
DESCRIPTION:Multiscale Mechanoimmunology: From Molecular Mechanisms to Precision Therapies \nLocation: 305 Shillman Hall \nAbstract: Multiscale Mechanoimmunology: From Molecular Mechanisms to Precision Therapies Therapeutic immune cells have the potential to treat complex diseases. Some therapies\, such as CAR T cells\, are effective against blood cancers but are not effective against solid cancers\, which comprise about 90% of adult cancers. A key requirement of the role of therapeutic cells in tumor eradication is their ability to migrate to and infiltrate the tumor. To accomplish this\, cells navigate various mechanoimmunological factors\, such as tissue viscoelasticity. One consequence of viscoelasticity is time-dependent stress relaxation – a decrease in stress in response to applied deformation. However\, the mechanisms by which viscoelasticity regulates migration are not fully understood. In addition\, limited studies have quantitatively compared the transport of cell therapies in tissue-like environments. My research aims to address these research gaps. To address the potential role of viscoelasticity on 3D cell migration\, I developed hydrogels that mimic the stress relaxation behavior of native tissues. I found that enhanced stress relaxation potentiates monocyte migration. Mechanistically\, our data support a model whereby WASP-mediated actin polymerization generates physical force at the leading edge of the cell to generate micron-sized channels for cells to migrate through. In a separate project\, I integrated macrophage phenotype and morphometric transitions. Together\, our studies establish a platform to determine the role of mechanical cues in shaping the immune response and to leverage fundamental mechanisms to enable the rational design of “living drugs.” \n\nKolade Adebowale will join the Shu Chien-Gene Lay Department of Bioengineering as an assistant professor in Spring 2025. Dr. Adebowale received his Ph.D. from Stanford University in 2021 under the guidance of Professor Ovijit Chaudhuri. Dr. Adebowale is a postdoctoral fellow with Professor Samir Mitragotri at Harvard University. While at Stanford\, Dr. Adebowale received the NSF GRFP\, a Stanford Graduate Fellowship\, and an NIH F31 grant. At Harvard\, Dr. Adebowale was awarded an NSF Ascend – MPS postdoctoral fellowship and was an NIH MOSAIC K99/R00 scholar. Dr. Adebowale’s main research areas are biomaterials\, mechanobiology\, and immunology. He seeks to integrate engineering design principles in cancer immunology to enable rational engineering and prediction of effective\, next-generation immune cell therapies. Furthermore\, Dr. Adebowale strives to understand how the complex functionality of the immune system arises from mechanical cues and simple biophysical principles. Dr. Adebowale is excited to teach and mentor the next generation of scientists and engineers.
URL:https://coe.northeastern.edu/event/chemical-engineering-fall-seminar-series-omokolade-adebowale/
LOCATION:305 Shillman\, 360 Huntington Ave\, 305 Shillman\, Boston\, MA\, 02115\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241204T120000
DTEND;TZID=America/New_York:20241204T130000
DTSTAMP:20260412T234704
CREATED:20240919T211327Z
LAST-MODIFIED:20240919T211405Z
UID:46249-1733313600-1733317200@coe.northeastern.edu
SUMMARY:UPLIFT 2024 - First Year Research Program
DESCRIPTION:The UPLIFT program is an academic year research program for first-year students across the College of Engineering. In the fall\, students are invited to attend a series of research seminars hosted by faculty. In the spring\, selected UPLIFT Students engage directly with CoE Faculty members to conduct research\, ~3-5 hours each week. Students are then encouraged to apply for an REU experience in the summer (Links: NSF REU Search | ETAPS REU Applications). Additional support (office hours\, monthly networking meetings\, and research support) is provided by the Center for STEM Education. \nIf you are a first-year COE student and interested in attending UPLIFT seminars in the Fall of 2024 (a requirement to apply for the program)\, please RSVP here:\nhttps://www.surveymonkey.com/r/UPLIFT2024-RSVP \nFall 2024 Seminar Schedule:\n(Tu) September 24 @ Snell Eng. 168:\nFrancisco Hung (CoE ChemE): Computational Development of Liposomes with Tailored Mechanical Properties \n(W) October 9 @ Snell Eng. 168:\nOzan Ozdemir (CoE MIE): Cold Spray and Wire Arc Additive Manufacturing Process Research \n(Tu) October 22 @ Snell Eng. 168:\nDamilola Daramola (CoE ChemE): Critical Materials from Waste Solids \n(W) November 6 @ Churchill 103:\nEric Anderson (CoE ECE)*: Resilient Communication Systems for Emergency Responders \n(Tu) November 12 @ Snell Eng. 168:\nPaul Stevenson (CoS Physics): Quantum Sensing with Defective Diamonds \n(W) December 4 @ Snell Eng. 168\nJacqueline McCleary (CoS Physics)*: Dust and Dark Matter at Megalight-year Scales \n* = to be confirmed
URL:https://coe.northeastern.edu/event/uplift-2024-first-year-research-program/2024-12-04/
LOCATION:168 SN\, 360 Huntington Ave\, Boston\, MA\, 02115\, United States
CATEGORIES:use the department, audience, and topic lists
ORGANIZER;CN="Michael B. Silevitch and Claire J. Duggan Center for STEM Education":MAILTO:stem@northeastern.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241205T080000
DTEND;TZID=America/New_York:20241205T113000
DTSTAMP:20260412T234704
CREATED:20241125T194049Z
LAST-MODIFIED:20241125T194049Z
UID:48110-1733385600-1733398200@coe.northeastern.edu
SUMMARY:Mechanical Engineering Capstone Day | Fall 2024
DESCRIPTION:The MIE Department invites you to the Fall 2024 Mechanical Engineering Capstone Day on Thursday\, December 5\, 2024\, from 8:00 AM to 11:30 AM. \nEvent Highlights: \n\nPitch Presentations: 8:00 AM – 10:00 AM\nLocations: SN 108\, SN 168\, CH 101\, CH 103\, MU 201\nPoster Session: 10:15 AM – 11:30 AM\nLocation: Curry Student Center Indoor Quad/Pit\n\nThis is your opportunity to explore the innovative projects our talented student teams have been working on for the last five months and engage with their work firsthand. We look forward to seeing you there!
URL:https://coe.northeastern.edu/event/mechanical-engineering-capstone-day-fall-2024/
LOCATION:Curry Student Center\, 360 Huntington Ave.\, Boston\, MA\, 02115\, United States
ORGANIZER;CN="Mechanical & Industrial Engineering":MAILTO:mie-web@coe.neu.edu
GEO:42.3394629;-71.0885286
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Curry Student Center 360 Huntington Ave. Boston MA 02115 United States;X-APPLE-RADIUS=500;X-TITLE=360 Huntington Ave.:geo:-71.0885286,42.3394629
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241205T120000
DTEND;TZID=America/New_York:20241205T130000
DTSTAMP:20260412T234704
CREATED:20240912T133852Z
LAST-MODIFIED:20241122T164919Z
UID:46096-1733400000-1733403600@coe.northeastern.edu
SUMMARY:LinkedIn\, CV\, Resume: CommLab Drop-In Workshops
DESCRIPTION:Join the CommLab’s empowering LinkedIn\, CV\, and Resume Drop-In Workshops any Thursday from 12 pm to 1 pm ET. This collaborative space offers valuable advice and peer feedback to enhance your online profile and professional presence. Join this workshop series through Zoom.
URL:https://coe.northeastern.edu/event/linkedin-cv-resume-commlab-drop-in-workshops-2/2024-12-05/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241209T100000
DTEND;TZID=America/New_York:20241209T140000
DTSTAMP:20260412T234704
CREATED:20241126T190630Z
LAST-MODIFIED:20241126T190630Z
UID:48153-1733738400-1733752800@coe.northeastern.edu
SUMMARY:MLOps Innovation Expo
DESCRIPTION:Please join us for the inaugural MLOps Innovation Expo\, a showcase of groundbreaking work in AI and machine learning by our talented students.\n\n📅 Date: Monday\, December 9\, 2024\n⏰ Time: 10:00 AM – 2:00 PM\n📍 Location: Curry Student Center Ballroom\n\nThis dynamic event is your chance to witness cutting-edge AI innovations\, connect with brilliant minds\, and contribute to shaping the future of machine learning.\n\nEvent Highlights\n\nProject Showcase: Experience end-to-end AI solutions tackling real-world challenges.\nNetworking Opportunities: Build connections with students and colleagues.\nCompetition: Cast your vote and help select the top projects through a blend of audience and faculty voting.\n\nDon’t miss this unique opportunity to celebrate the talent and creativity within our MIE community.\nWe hope to see you there!
URL:https://coe.northeastern.edu/event/mlops-innovation-expo/
LOCATION:Curry Student Center\, 360 Huntington Ave.\, Boston\, MA\, 02115\, United States
ORGANIZER;CN="Mechanical & Industrial Engineering":MAILTO:mie-web@coe.neu.edu
GEO:42.3394629;-71.0885286
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Curry Student Center 360 Huntington Ave. Boston MA 02115 United States;X-APPLE-RADIUS=500;X-TITLE=360 Huntington Ave.:geo:-71.0885286,42.3394629
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241210T140000
DTEND;TZID=America/New_York:20241210T160000
DTSTAMP:20260412T234704
CREATED:20241202T144836Z
LAST-MODIFIED:20241202T144836Z
UID:48214-1733839200-1733846400@coe.northeastern.edu
SUMMARY:ChE PhD Dissertation Defense: Peng Zhao
DESCRIPTION:Name:\nPeng Zhao \nTitle:\nImpact of ECM-Based Hydrogel Delivery Vehicle Properties on Cell Survival in a 3D In Vitro Injection Model for Retinal Progenitor Cell Transplantation \nDate:\n12/10/2024 \nTime:\n2:00:00 PM \nCommittee Members:\nProf. Rebecca Carrier (Advisor)\nProf. Abigail Koppes\nProf. Sidi Bencherif\nProf. Michael Young \nLocation:\nEXP 610-A \nAbstract:\nAge-related macular degeneration (AMD) is the leading cause of vision loss globally and a form of retinal degenerative (RD) disease. Current treatments\, such as gene therapy\, drugs\, laser procedures\, and neuroprotective approaches\, cannot restore the photoreceptors lost in RD diseases. Cell transplantation into the subretinal space shows potential to enhance visual function\, but low cell survival and efflux from the injection site present major obstacles. Mechanical forces during injection can severely damage cells\, and the host microenvironment may further contribute to cell death. Following high-density subretinal injection\, a compact cell bolus may form\, resulting in nutrient depletion\, low oxygen levels\, pH imbalances\, and waste accumulation—factors that exacerbate cell death. \nBiomaterial scaffolds have been employed to improve cell survival and differentiation\, though the ideal scaffold cues for supporting transplanted cell survival and integration remain undetermined. In this study\, we developed a three-dimensional (3D) in vitro injection model to simulate subretinal bolus injection. Using this model\, we found that the injection process and bolus microenvironment negatively impact human retinal progenitor cell (hRPC) viability\, promoting apoptosis. Alginate-based hydrogels of varying stiffness and extracellular matrix (ECM) molecule compositions were created using factorial design. hRPC viability\, apoptosis\, and migration within the formed hydrogels were investigated through the 3D in vitro injection model and a 3D invasion assay. Factorial design analysis revealed that higher stiffness and the inclusion of laminin and hyaluronic acid enhance hRPC survival and 3D migration. \nOne challenge with studying cell responses in the context of cell transplantation is the inability to easily visualize cells at the transplantation site over time. Compared to traditional in vitro cultures\, retinal explant models that retain native tissue structure and neuronal connections could provide physiologically relevant insights. Here\, we developed a novel explant model for hRPC transplantation\, wherein alginate-based hydrogels containing hRPCs were injected adjacent to cross-sectional retinal tissue slices. This setup allows visualization of the cells’ position relative to retinal tissue layers over time. Key cell behaviors\, including migration\, attachment\, invasion\, viability\, and apoptosis\, were tracked in real-time using confocal microscopy.
URL:https://coe.northeastern.edu/event/che-phd-dissertation-defense-peng-zhao/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241211T090000
DTEND;TZID=America/New_York:20241211T110000
DTSTAMP:20260412T234704
CREATED:20240830T155557Z
LAST-MODIFIED:20241122T164831Z
UID:45488-1733907600-1733914800@coe.northeastern.edu
SUMMARY:Graduate Student Drop-In Writing Hours
DESCRIPTION:Graduate students\, are you looking for a place for focused research writing time?  Join the CommLab drop-in writing hours any Wednesday between 9 -11 am ET.  Drop in any Wednesday and stay for a short time or two hours.  A CommLab Fellow will also be available to provide feedback on your writing.  We will be meeting in weekly in 334 Curry Student Center.  Note we will meet in 336 Curry Student Center on Wednesday\, September 25th.
URL:https://coe.northeastern.edu/event/graduate-student-drop-in-writing-hours/2024-12-11/
LOCATION:Curry Student Center\, 360 Huntington Ave.\, Boston\, MA\, 02115\, United States
GEO:42.3394629;-71.0885286
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Curry Student Center 360 Huntington Ave. Boston MA 02115 United States;X-APPLE-RADIUS=500;X-TITLE=360 Huntington Ave.:geo:-71.0885286,42.3394629
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241211T173000
DTEND;TZID=America/New_York:20241211T183000
DTSTAMP:20260412T234704
CREATED:20241023T141330Z
LAST-MODIFIED:20241023T141330Z
UID:47403-1733938200-1733941800@coe.northeastern.edu
SUMMARY:Gordon Institute Virtual Information Session
DESCRIPTION:Learn how you can earn a Graduate Certificate in Engineering Leadership as a stand-alone certificate or in combination with one of twenty-three Master of Science degrees offered through Northeastern’s College of Engineering\, College of Science\, or Khoury College of Computer Sciences. \nThe National Academy of Engineering recognized The Gordon Institute of Engineering Leadership (GIEL) for its innovative curriculum\, which combines technical education\, leadership capabilities\, and the “Challenge Project”—an opportunity for students to receive master’ s-level credit while working in industry. \nBy aligning technical proficiency with leadership capabilities\, GIEL accelerates the development of high-potential engineers and prepares them to lead complex projects early in their careers. Upon completing the program\, more than 88% of the 2022 class reported increased leadership responsibility\, while more than 50% of the 2022 class reported being promoted within one year of graduation. \nOur Director of Admissions will answer your application questions for Fall 2025. \nYou will have the opportunity to hear from alumni about how The Gordon Institute propelled their engineering careers. Program professors will also be present to answer curriculum questions.
URL:https://coe.northeastern.edu/event/gordon-institute-virtual-information-session-29/
ORGANIZER;CN="Gordon Engineering Leadership program":MAILTO:gordonleadership@northeastern.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241212T120000
DTEND;TZID=America/New_York:20241212T130000
DTSTAMP:20260412T234704
CREATED:20240912T133852Z
LAST-MODIFIED:20241122T164919Z
UID:46097-1734004800-1734008400@coe.northeastern.edu
SUMMARY:LinkedIn\, CV\, Resume: CommLab Drop-In Workshops
DESCRIPTION:Join the CommLab’s empowering LinkedIn\, CV\, and Resume Drop-In Workshops any Thursday from 12 pm to 1 pm ET. This collaborative space offers valuable advice and peer feedback to enhance your online profile and professional presence. Join this workshop series through Zoom.
URL:https://coe.northeastern.edu/event/linkedin-cv-resume-commlab-drop-in-workshops-2/2024-12-12/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241213T140000
DTEND;TZID=America/New_York:20241213T160000
DTSTAMP:20260412T234704
CREATED:20241202T144950Z
LAST-MODIFIED:20241202T144950Z
UID:48223-1734098400-1734105600@coe.northeastern.edu
SUMMARY:ChE PhD Dissertation Defense: Yuan Li
DESCRIPTION:Name:\nYuan Li \nTitle:\nEstablishing a Physiologically Relevant Upper Gastrointestinal In Vitro Model Incorporating Bile Salts and Simplified Commensal Microbial Consortium \nDate:\n12/13/2024 \nTime:\n2:00:00 PM \nCommittee Members:\nProf. Rebecca Carrier (Advisor)\nProf. Abigail Koppes\nProf. Erel Levine\nProf. Jiahe Li \nLocation:\nEXP 610-A \nAbstract:\nBacteria-epithelial-immune crosstalk plays crucial roles in intestinal physiology. Bile salts (BS) act as critical modulators of these interactions\, influencing health and disease. Tools for studying interactions between BS\, microbes\, and host cells within the human intestinal mucosa are lacking. \nIn this project\, we developed in vitro intestinal models for studying bacteria-epithelial-immune crosstalk. First\, the impacts of individual BS (sodium taurocholate\, NaTC; sodium glycochenodeoxycholate\, NaGCDC; and sodium tauroursodeoxycholate\, NaTUDC) on human primary intestinal epithelial monolayer co-cultures with Escherichia coli were studied. We observed that high BS concentrations disrupted barrier function\, as evidenced by reduced transepithelial electrical resistance (TEER)\, with NaGCDC causing the most significant damage. Interestingly\, the addition of phyosphatidylcholine (PC) and E. coli were observed to mitigate the BS-induced monolayer TEER reductions. \nTo enhance the model’s physiological relevance\, we next incorporated a simplified model bile (including NaTC\, NaGCDC\, NaTUDC\, and PC)\, an apical hypoxic environment\, dendritic cells\, and a simplified commensal microbial consortium (Streptococcus mitis\, Clostridium bifermentans\, Prevotella melaninogenica\, and Bifidobacterium longum). 4/1 mM concentrations of BS/PC micelles were observed to damage the epithelial barrier under hypoxic but not normoxic conditions. However\, incorporation of the bacterial consortium protected the epithelium from BS/PC – associated damage. Furthermore\, the presence of BS/PC alleviated barrier damage and inflammatory response induced by co-culture with the bacterial consortium\, potentially in part through modulation of bacterial growth. In addition\, we observed thicker mucus layers not only impacted the growth of consortium strains\, resulting in enhanced growth of the probiotic Bifidobacterium longum\, but also reduced inflammatory responses to bacteria and BS/PC-induced epithelial damage. In general\, our in vitro model revealed that commensal microbes mitigate BS and BS/PC toxicity to the epithelial monolayer\, while BS helps alleviate monolayer damage and inflammatory response caused by commensal microbes. \nIn preparation for transferring the developed model from static cell culture inserts to microfluidic devices for mimicking intestinal fluidic stimuli and enabling facile visualization of the mucosal interface\, we designed a gut-on-chip platform with a vertical hydrogel-cultured epithelial monolayer. Three hydrogels (crosslinked collagen type I\, PEG-VS\, and PEG-SG-PLL) were evaluated for compatibility with human primary intestinal epithelial stem cells (HPIESCs). Collagen type I and PEG-SG-PLL were found to support HPIESC adhesion and monolayer formation\, but collagen lost structural integrity under flow. PEG-VS\, though functionalized with cell-binding peptides\, only enabled partial monolayer formation. Notably\, encapsulating organoids in PEG-VS near the gel-medium interface enabled crypt-like monolayer formation through organoid-driven gel re-structuring. Furthermore\, we found that flow enhanced epithelial differentiation on PEG-SG-PLL and PEG-VS (encapsulation method)\, leading to thicker monolayers with taller columnar cells compared to static culture. These findings show PEG-SG-PLL and PEG-VS are good candidates for enabling transition of the bile-intestinal model to microfluidic chip platforms.
URL:https://coe.northeastern.edu/event/che-phd-dissertation-defense-yuan-li/
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DTSTART;TZID=America/New_York:20241218T090000
DTEND;TZID=America/New_York:20241218T110000
DTSTAMP:20260412T234704
CREATED:20240830T155557Z
LAST-MODIFIED:20241122T164831Z
UID:45489-1734512400-1734519600@coe.northeastern.edu
SUMMARY:Graduate Student Drop-In Writing Hours
DESCRIPTION:Graduate students\, are you looking for a place for focused research writing time?  Join the CommLab drop-in writing hours any Wednesday between 9 -11 am ET.  Drop in any Wednesday and stay for a short time or two hours.  A CommLab Fellow will also be available to provide feedback on your writing.  We will be meeting in weekly in 334 Curry Student Center.  Note we will meet in 336 Curry Student Center on Wednesday\, September 25th.
URL:https://coe.northeastern.edu/event/graduate-student-drop-in-writing-hours/2024-12-18/
LOCATION:Curry Student Center\, 360 Huntington Ave.\, Boston\, MA\, 02115\, United States
GEO:42.3394629;-71.0885286
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Curry Student Center 360 Huntington Ave. Boston MA 02115 United States;X-APPLE-RADIUS=500;X-TITLE=360 Huntington Ave.:geo:-71.0885286,42.3394629
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DTSTART;TZID=America/New_York:20241219T120000
DTEND;TZID=America/New_York:20241219T130000
DTSTAMP:20260412T234704
CREATED:20240912T133852Z
LAST-MODIFIED:20241122T164920Z
UID:46098-1734609600-1734613200@coe.northeastern.edu
SUMMARY:LinkedIn\, CV\, Resume: CommLab Drop-In Workshops
DESCRIPTION:Join the CommLab’s empowering LinkedIn\, CV\, and Resume Drop-In Workshops any Thursday from 12 pm to 1 pm ET. This collaborative space offers valuable advice and peer feedback to enhance your online profile and professional presence. Join this workshop series through Zoom.
URL:https://coe.northeastern.edu/event/linkedin-cv-resume-commlab-drop-in-workshops-2/2024-12-19/
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BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20241220T180000
DTEND;TZID=Asia/Kolkata:20241220T190000
DTSTAMP:20260412T234704
CREATED:20241210T145106Z
LAST-MODIFIED:20241210T145106Z
UID:48287-1734717600-1734721200@coe.northeastern.edu
SUMMARY:Virtual Monthly Coffee Hour with Neha!
DESCRIPTION:Join us for a coffee hour as Neha\, College of Engineering enrollment coach in India\, hosts a virtual webinar where you’ll: \n\nLearn about our programs and co-op opportunities within the College of Engineering.\nExplore the various campuses and impressive resources.\nLearn about internal and external scholarships that you may qualify for.\nGain insight into the application process.
URL:https://coe.northeastern.edu/event/virtual-monthly-coffee-hour-with-neha/
ORGANIZER;CN="Graduate School of Engineering":MAILTO:coe-gradadmissions@northeastern.edu
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