BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Northeastern University College of Engineering - ECPv6.16.5.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Northeastern University College of Engineering
X-ORIGINAL-URL:https://coe.northeastern.edu
X-WR-CALDESC:Events for Northeastern University College of Engineering
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20250309T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20251102T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20260308T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20261101T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20270314T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20271107T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20260602T100000
DTEND;TZID=America/New_York:20260602T110000
DTSTAMP:20260527T134018Z
CREATED:20260527T134018Z
LAST-MODIFIED:20260527T134018Z
UID:56639-1780394400-1780398000@coe.northeastern.edu
SUMMARY:Crafting Data Visuals to Tell a Scientific Story: CommLab Drop-In Hours
DESCRIPTION:Looking to illustrate your data? Join the CommLab Data Visualization Drop-In sessions Tuesdays from 10-11am on Zoom to discuss strategies or receive feedback on your data visualization process.
URL:https://coe.northeastern.edu/event/crafting-data-visuals-to-tell-a-scientific-story-commlab-drop-in-hours-2/2026-06-02/
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260603
DTEND;VALUE=DATE:20260608
DTSTAMP:20260205T151005Z
CREATED:20260205T151005Z
LAST-MODIFIED:20260205T151005Z
UID:55388-1780444800-1780876799@coe.northeastern.edu
SUMMARY:3rd CV4Smalls Workshop Computer Vision with Small Data: Beyond Scale Toward Data-Efficient Dynamically-Aware Video Intelligence
DESCRIPTION:While foundation models keep scaling\, many real-world domains still face scarce\, costly\, and complex data. That’s why we’re excited to bring the 3rd CV4Smalls Workshop to CVPR 2026 with a new theme: \nBeyond Scale: Toward Data-Efficient & Dynamically-Aware Video Intelligence \nWorking on small-data video understanding? We’d love to have you join the conversation — submit your work or participate in our upcoming challenge! \nPaper Deadline: March 4\, 2026 (CVPR format)Challenge Track: Coming soon with Voxel51 and TwelveLabs🌐 https://lnkd.in/eq3Taarx \nSee the flyer for keynote speakers and the full list of topics — hope to see you there!
URL:https://coe.northeastern.edu/event/3rd-cv4smalls-workshop-computer-vision-with-small-data-beyond-scale-toward-data-efficient-dynamically-aware-video-intelligence/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20260603T120000
DTEND;TZID=America/New_York:20260603T130000
DTSTAMP:20260505T202142Z
CREATED:20260505T202004Z
LAST-MODIFIED:20260505T202142Z
UID:56424-1780488000-1780491600@coe.northeastern.edu
SUMMARY:Bioengineering Student WIP Seminar - Summer '26
DESCRIPTION:Work in Progress (WIP) seminars with Bioengineering PhD students. Weekly in 121 Snell Library from 12-1pm on Wednesdays during Summer 1. \nAll are welcome! \n\n\n\n\nPhD Candidate\nFaculty Advisor\n\n\nMAY\n\n\n5/6\nQiaochu Liu\nLei Wang\n\n\n\nMitchell Thomas\nJing-Ke Weng\n\n\n5/13\nSophia Millan\nAmir Vahabikashi\n\n\n\nYsabel del Fierro\nRebecca Willits\n\n\n5/20\nRui Tang\nNeel Joshi\n\n\n\nXiwen Zhao\nMingyang Lu\n\n\n5/27\nNeelabh Sharma\nElizabeth Libby\n\n\n\nKatya Karpova\nGuohao Dai\n\n\nJUNE\n\n\n6/3\nFan-Yu Yen\nQianqian Fang\n\n\n\nHannah Harens\nNikolai Slavov\n\n\n6/10\nGrace Flynn\nGuohao Dai\n\n\n\nIvonne Lozano\nBryan Spring\n\n\n6/17\nMasoud Keramati\nMary Jo Ondrechen\n\n\n\nAshlyn McCann\nQianqian Fang
URL:https://coe.northeastern.edu/event/bioengineering-student-wip-seminar-summer-26/2026-06-03/
ORGANIZER;CN="Bioengineering":MAILTO:bioe@northeastern.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20260603T140000
DTEND;TZID=America/New_York:20260603T160000
DTSTAMP:20260527T193616Z
CREATED:20260527T193616Z
LAST-MODIFIED:20260527T193616Z
UID:56671-1780495200-1780502400@coe.northeastern.edu
SUMMARY:Chemical Engineering GSC CV/Resume Workshop
DESCRIPTION:The Chemical Engineering Graduate Student Council is inviting fellow students to attend an upcoming CV/Resume Workshop designed to help you strengthen your academic and professional applications. \nPlease RSVP \nThis workshop will cover: \n\nResume and CV formatting\nTailoring applications for internships\, fellowships\, and jobs\nCommon mistakes to avoid in CV/Resume\n\nWe encourage all graduate students to attend and take advantage of this opportunity to improve their professional documents.
URL:https://coe.northeastern.edu/event/chemical-engineering-gsc-cv-resume-workshop/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20260604T120000
DTEND;TZID=America/New_York:20260604T140000
DTSTAMP:20260408T134231Z
CREATED:20260408T134231Z
LAST-MODIFIED:20260408T134231Z
UID:56217-1780574400-1780581600@coe.northeastern.edu
SUMMARY:COE Research Expo
DESCRIPTION:The College of Engineering is excited to announce the eighth annual COE PhD Research Expo. The Expo is a fantastic opportunity for PhD students to highlight their research and for faculty and students to network and talk about research in a friendly environment.
URL:https://coe.northeastern.edu/event/coe-research-expo-2/
LOCATION:Curry Student Center\, 360 Huntington Ave.\, Boston\, MA\, 02115\, United States
ORGANIZER;CN="Graduate School of Engineering":MAILTO:coe-gradadmissions@northeastern.edu
GEO:42.3394629;-71.0885286
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Curry Student Center 360 Huntington Ave. Boston MA 02115 United States;X-APPLE-RADIUS=500;X-TITLE=360 Huntington Ave.:geo:-71.0885286,42.3394629
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20260605T110000
DTEND;TZID=America/New_York:20260605T120000
DTSTAMP:20260602T144238Z
CREATED:20260602T144238Z
LAST-MODIFIED:20260602T144238Z
UID:56714-1780657200-1780660800@coe.northeastern.edu
SUMMARY:QMSI Seminar - “Probing correlated states with excitons in van der Waals heterostructures” - Prof. Andrew Y. Joe
DESCRIPTION:SEMINAR\nQuantum Materials and Sensing Institute (QMSI)\n“Probing correlated states with excitons in van der Waals heterostructures”\nProf. Andrew Y. Joe\nPhysics and Astronomy\nUniversity of California\, Riverside \nFriday\, June 05\, 2026\, 11:00 am – 12:00 pm\nVenue: Elliott Hall – Room 130C\n147 South Bedford St\, Burlington\, MA \nThe seminar is both in person and online\nPizza will be served \nAbstract: Since the isolation of atomically thin van der Waals (vdW) materials\, vdW heterostructures have been used to engineer new quantum phenomena at the two-dimensional (2D) limit. Semiconducting transition metal dichalcogenide (TMD) monolayers are of particular interest because they serve as a highly tunable platform hosting both 2D electron gases and light-induced electron-hole bound pairs\, known as excitons. In this talk\, I will demonstrate how we utilize excitons as highly sensitive optical probes to explore correlated electronic behavior in these systems. First\, I will highlight their use in studying correlated electron-hole fluids\, revealing the formation of interlayer excitons and perfect Coulomb drag. I will then present recent work from my group exploring correlated insulating phases in TMD moiré heterostructures. By performing optical spectroscopy\, we identify moiré-induced exciton species that can detect charge localization between different moiré sites and layers. Together\, these findings establish excitons as a versatile optical probe for mapping the complex landscape of correlated electron phenomena in van der Waals systems. \nBio: Andrew Joe is an Assistant Professor in the Department of Physics and Astronomy at the University of California\, Riverside. Prior to joining UC Riverside\, he was a postdoctoral fellow at UC Berkeley and the Lawrence Berkeley National Laboratory (LBNL)\, where his research focused on electrostatically created interlayer excitons. He received his Ph.D. in Physics from Harvard University\, working with Philip Kim and earned his B.A. in Physics from Cornell University. As an experimental condensed matter physicist\, his research centers on discovering novel quantum phenomena in low-dimensional materials. By combining advanced electrostatic control and nanoscale device engineering\, his group investigates moiré superlattices in van der Waals heterostructures\, strongly correlated electron-hole fluids\, and emerging electronic and optoelectronic properties in novel quantum materials.\n________________________________________________________________________________ \n\nMicrosoft Teams meeting\nJoin: https://teams.microsoft.com/meet/229273301684794?p=QiVtiYaOtA1y6FhM2X\nMeeting ID: 229 273 301 684 794\nPasscode: bS2Qt9xn
URL:https://coe.northeastern.edu/event/qmsi-seminar-probing-correlated-states-with-excitons-in-van-der-waals-heterostructures-prof-andrew-y-joe/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20260609T100000
DTEND;TZID=America/New_York:20260609T110000
DTSTAMP:20260527T134019Z
CREATED:20260527T134019Z
LAST-MODIFIED:20260527T134019Z
UID:56640-1780999200-1781002800@coe.northeastern.edu
SUMMARY:Crafting Data Visuals to Tell a Scientific Story: CommLab Drop-In Hours
DESCRIPTION:Looking to illustrate your data? Join the CommLab Data Visualization Drop-In sessions Tuesdays from 10-11am on Zoom to discuss strategies or receive feedback on your data visualization process.
URL:https://coe.northeastern.edu/event/crafting-data-visuals-to-tell-a-scientific-story-commlab-drop-in-hours-2/2026-06-09/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20260610T100000
DTEND;TZID=America/New_York:20260610T120000
DTSTAMP:20260610T142350Z
CREATED:20260610T142350Z
LAST-MODIFIED:20260610T142350Z
UID:56914-1781085600-1781092800@coe.northeastern.edu
SUMMARY:Teach AI to Print Electronics: A Hands-On Course in AI-driven Digital Twins for Flexible and Hybrid Electronics
DESCRIPTION:Benyamin Davaji\, Assistant Professor of Electrical and Computer Engineering at Northeastern University\, and Haiyang Yun\, Senior PhD Student\, will present: “Digital Twins for Printed Electronics: How Can AI Learn FHE Printing?“\, part of the SEMI Flexible Electronics Master Class series. \nDrawing on collaborative research from the Autonomous Integrated Microsystems (AIMS) Laboratory\, the course introduces deep neural network-based digital twins that connect design\, fabrication\, and metrology data to enable real-time process monitoring and optimization in flexible hybrid electronics manufacturing. Attendees will work through the complete digital twin workflow – image processing\, virtual metrology\, AI model training\, and hyperparameter tuning – and build their own digital twin using real-world datasets in a hands-on Google Colab module. \nStudent attendance is free and strongly encouraged. Students can register using their university email address and a valid student ID.
URL:https://coe.northeastern.edu/event/teach-ai-to-print-electronics-a-hands-on-course-in-ai-driven-digital-twins-for-flexible-and-hybrid-electronics/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20260610T120000
DTEND;TZID=America/New_York:20260610T130000
DTSTAMP:20260505T202142Z
CREATED:20260505T202004Z
LAST-MODIFIED:20260505T202142Z
UID:56425-1781092800-1781096400@coe.northeastern.edu
SUMMARY:Bioengineering Student WIP Seminar - Summer '26
DESCRIPTION:Work in Progress (WIP) seminars with Bioengineering PhD students. Weekly in 121 Snell Library from 12-1pm on Wednesdays during Summer 1. \nAll are welcome! \n\n\n\n\nPhD Candidate\nFaculty Advisor\n\n\nMAY\n\n\n5/6\nQiaochu Liu\nLei Wang\n\n\n\nMitchell Thomas\nJing-Ke Weng\n\n\n5/13\nSophia Millan\nAmir Vahabikashi\n\n\n\nYsabel del Fierro\nRebecca Willits\n\n\n5/20\nRui Tang\nNeel Joshi\n\n\n\nXiwen Zhao\nMingyang Lu\n\n\n5/27\nNeelabh Sharma\nElizabeth Libby\n\n\n\nKatya Karpova\nGuohao Dai\n\n\nJUNE\n\n\n6/3\nFan-Yu Yen\nQianqian Fang\n\n\n\nHannah Harens\nNikolai Slavov\n\n\n6/10\nGrace Flynn\nGuohao Dai\n\n\n\nIvonne Lozano\nBryan Spring\n\n\n6/17\nMasoud Keramati\nMary Jo Ondrechen\n\n\n\nAshlyn McCann\nQianqian Fang
URL:https://coe.northeastern.edu/event/bioengineering-student-wip-seminar-summer-26/2026-06-10/
ORGANIZER;CN="Bioengineering":MAILTO:bioe@northeastern.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20260616T100000
DTEND;TZID=America/New_York:20260616T110000
DTSTAMP:20260527T134019Z
CREATED:20260527T134019Z
LAST-MODIFIED:20260527T134019Z
UID:56641-1781604000-1781607600@coe.northeastern.edu
SUMMARY:Crafting Data Visuals to Tell a Scientific Story: CommLab Drop-In Hours
DESCRIPTION:Looking to illustrate your data? Join the CommLab Data Visualization Drop-In sessions Tuesdays from 10-11am on Zoom to discuss strategies or receive feedback on your data visualization process.
URL:https://coe.northeastern.edu/event/crafting-data-visuals-to-tell-a-scientific-story-commlab-drop-in-hours-2/2026-06-16/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20260617T120000
DTEND;TZID=America/New_York:20260617T130000
DTSTAMP:20260505T202143Z
CREATED:20260505T202004Z
LAST-MODIFIED:20260505T202143Z
UID:56426-1781697600-1781701200@coe.northeastern.edu
SUMMARY:Bioengineering Student WIP Seminar - Summer '26
DESCRIPTION:Work in Progress (WIP) seminars with Bioengineering PhD students. Weekly in 121 Snell Library from 12-1pm on Wednesdays during Summer 1. \nAll are welcome! \n\n\n\n\nPhD Candidate\nFaculty Advisor\n\n\nMAY\n\n\n5/6\nQiaochu Liu\nLei Wang\n\n\n\nMitchell Thomas\nJing-Ke Weng\n\n\n5/13\nSophia Millan\nAmir Vahabikashi\n\n\n\nYsabel del Fierro\nRebecca Willits\n\n\n5/20\nRui Tang\nNeel Joshi\n\n\n\nXiwen Zhao\nMingyang Lu\n\n\n5/27\nNeelabh Sharma\nElizabeth Libby\n\n\n\nKatya Karpova\nGuohao Dai\n\n\nJUNE\n\n\n6/3\nFan-Yu Yen\nQianqian Fang\n\n\n\nHannah Harens\nNikolai Slavov\n\n\n6/10\nGrace Flynn\nGuohao Dai\n\n\n\nIvonne Lozano\nBryan Spring\n\n\n6/17\nMasoud Keramati\nMary Jo Ondrechen\n\n\n\nAshlyn McCann\nQianqian Fang
URL:https://coe.northeastern.edu/event/bioengineering-student-wip-seminar-summer-26/2026-06-17/
ORGANIZER;CN="Bioengineering":MAILTO:bioe@northeastern.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20260617T173000
DTEND;TZID=America/New_York:20260617T183000
DTSTAMP:20260604T182441Z
CREATED:20260604T182441Z
LAST-MODIFIED:20260604T182441Z
UID:56814-1781717400-1781721000@coe.northeastern.edu
SUMMARY:The Gordon Institute: Virtual Information Session
DESCRIPTION:Learn how you can earn a Graduate Certificate in Engineering Leadership as a stand-alone certificate or in combination with one of over 25 Master of Science degrees offered through Northeastern’s College of Engineering\, College of Science\, or Khoury College of Computer Sciences. \nOur Director of Admissions will be answering your application questions for Fall 2026. \nYou will have the opportunity to meet Alumni and hear how The Gordon Institute propelled their engineering careers. Program professors will also be present to answer curriculum questions. \nThe Gordon Institute also offers one-on-one info calls with admissions representatives. If you are interested in scheduling a call\, please contact Amy Manley at a.manley@northeastern.edu. \nRegister
URL:https://coe.northeastern.edu/event/the-gordon-institute-virtual-information-session-5/
ORGANIZER;CN="Gordon Engineering Leadership program":MAILTO:gordonleadership@northeastern.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20260618T090000
DTEND;TZID=America/New_York:20260618T160000
DTSTAMP:20260615T140408Z
CREATED:20260615T140017Z
LAST-MODIFIED:20260615T140408Z
UID:56930-1781773200-1781798400@coe.northeastern.edu
SUMMARY:Bioengineering PhD Research Symposium 2026
DESCRIPTION:8:45am-9:20am\nCSC Ballroom\nBreakfast\n\n\n9:20am-10:00am\nCSC Ballroom\nIntroductions and Keynote Speaker with Lee Makowski\, Professor of Bioengineering and Chemistry and Chemical Biology\n\n\n10:00am-11:05am\nCSC Ballroom\nOral Presentations with Bioengineering PhD Students\nHarry Akligoh\, PhD Candidate\nAndrew Selvadoss\, PhD Candidate\nDaniel Labbe\, PhD Candidate\nNathan Caso\, PhD Candidate\nSahana Gangadharan\, PhD Candidate\n(10-minute break)\n\n\n11:15am-12:30pm\nCSC McLeod\nPoster Session\n\n\n12:30pm-1:30pm\nCSC Ballroom\nLunch\n\n\n1:30pm-2:15pm\nCSC Ballroom\nPanel Session\n\n\n2:15pm-3:00pm\nCSC Ballroom\nRapidFire Presentations with Bioengineering PhD Students\nConnor Powell\, PhD Candidate\nAbdulrahman Kobayter\, PhD Student\nCatherine “Katya” Karpova\, PhD Candidate\nAleksei Krotov\, PhD Candidate\nAiden Lewis\, PhD Candidate\nAshlyn McCann\, PhD Candidate\n\n\n3:00pm-3:45pm\nCSC Ballroom\nIndustry Speaker with Chuck Goldstone\, Professor of Practice of Business and Communication at Hult International Business School\n(15-minute break)\n\n\n4:00pm\nCSC Ballroom\nAwards Ceremony
URL:https://coe.northeastern.edu/event/bioengineering-phd-research-symposium-2026/
LOCATION:Curry Student Center\, 360 Huntington Ave.\, Boston\, MA\, 02115\, United States
ORGANIZER;CN="Bioengineering":MAILTO:bioe@northeastern.edu
GEO:42.3394629;-71.0885286
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Curry Student Center 360 Huntington Ave. Boston MA 02115 United States;X-APPLE-RADIUS=500;X-TITLE=360 Huntington Ave.:geo:-71.0885286,42.3394629
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20260622T110000
DTEND;TZID=America/New_York:20260622T160000
DTSTAMP:20260604T181908Z
CREATED:20260604T181908Z
LAST-MODIFIED:20260604T181908Z
UID:56769-1782126000-1782144000@coe.northeastern.edu
SUMMARY:STEM Pride Table at Snell Library Lobby\, Boston
DESCRIPTION:Join the Northeastern University Library in promotion of STEM resources about LGBTQIA+ topics. The table will be staffed from 11-1pm but you are welcome to visit any time. You can also peruse our list of recommended reads. If you have any suggestions for inclusion on the list\, please email STEM Librarian Alyn Gamble.
URL:https://coe.northeastern.edu/event/stem-pride-table-at-snell-library-lobby-boston/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20260623T100000
DTEND;TZID=America/New_York:20260623T110000
DTSTAMP:20260527T134020Z
CREATED:20260527T134020Z
LAST-MODIFIED:20260527T134020Z
UID:56642-1782208800-1782212400@coe.northeastern.edu
SUMMARY:Crafting Data Visuals to Tell a Scientific Story: CommLab Drop-In Hours
DESCRIPTION:Looking to illustrate your data? Join the CommLab Data Visualization Drop-In sessions Tuesdays from 10-11am on Zoom to discuss strategies or receive feedback on your data visualization process.
URL:https://coe.northeastern.edu/event/crafting-data-visuals-to-tell-a-scientific-story-commlab-drop-in-hours-2/2026-06-23/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20260624T123000
DTEND;TZID=America/New_York:20260624T133000
DTSTAMP:20260608T185600Z
CREATED:20260608T185600Z
LAST-MODIFIED:20260608T185600Z
UID:56868-1782304200-1782307800@coe.northeastern.edu
SUMMARY:ChE PhD Dissertation Defense: Natesan Mani
DESCRIPTION:Name:\nNatesan Mani \nTitle:\nA Tale of Two Fcs: Investigating Furin cleavage in the SARS-CoV-2 Spike Protein and Glycan Effects in IgG Fcs \nDate:\n06/24/2026 \nTime:\n12:30:00 PM \nCommittee Members:\nProf. Srirupa Chakraborty (Advisor)\nProf. Francisco Hung\nProf. Sunny Zhou\nDr. Alla Polozova \nLocation:\n409 Robinson Hall \nAbstract:\nThis dissertation examines critical structural dynamics in viral infection and antibody-mediated immune response using Molecular Dynamics (MD) simulations. We investigated two distinct but fundamentally related systems: the SARS-CoV-2 Spike protein with emphasis on Furin cleavage (the antigen Fc)\, and the IgG1 Fc-CD16a receptor interaction with varying glycosylation profiles (the antibody Fc). \nAntigen Study: The SARS-CoV-2 Spike protein’s furin cleavage site (FCS) is a defining feature that distinguishes it from its predecessor SARS-CoV and is critical to viral infectivity. While extensive vaccine research has utilized stabilized Spike constructs with mutated or deleted FCS\, physiologically\, the cleavage occurs during viral particle formation. Using large-scale atomistic MD simulations of both Furin Cleaved and Uncleaved Spike proteins in the receptor-binding domain (RBD) Open and Closed conformations\, we demonstrate that furin cleavage fundamentally alters the Spike protein’s conformational dynamics. We observe increased correlated motions between the RBD and N-terminal domain (NTD) in the Furin Cleaved systems\, enhanced RBD sampling of exposed conformations favorable for ACE2 binding and altered glycan clustering patterns on key N-linked glycans. These observations provide quantitative evidence that cleavage primes the Spike protein for membrane fusion and enhances receptor accessibility. These findings provide a mechanistic foundation for designing immunogens and therapeutics targeting not only SARS-CoV-2 but also emerging Sarbecoviruses and related viral families. \nAntibody Study: IgG1 is the predominant antibody subclass used in therapeutic applications\, with its Fc region mediating critical effector functions including antibody-dependent cellular cytotoxicity (ADCC) through CD16a receptor engagement on natural killer cells. The glycosylation profiles of both the IgG1 Fc and CD16a receptor play essential roles in determining binding affinity and immune response magnitude. Using MD simulations of 22 distinct glycoform combinations\, we systematically examine how variations in core fucosylation and terminal galactosylation affect Fc-CD16a complex formation and stability. We evaluate the structural impact of asymmetric binding between the two Fc arms and the receptor\, calculate binding affinities and correlate structural observations with binding energetics. Our results validate known trends (afucosylation enhancement) while revealing nuanced effects of galactosylation and chain-specific glycan positioning. Together\, these findings and the accompanying mechanistic framework provide a foundation for the glycan-informed rational design of next-generation antibody therapeutics with enhanced immune potency \nTogether\, these studies demonstrate how atomistic molecular dynamics can bridge gaps between structural biology and functional outcomes\, providing quantitative frameworks for designing improved viral vaccines and enhanced therapeutic antibodies. The methodologies and insights presented here have broad applicability to understanding glycoprotein-receptor interactions across biological systems. \n\nNatesan Mani is a PhD candidate in Chemical Engineering at Northeastern University\, where he expects to defend in June 2026. He completed his M.S. in Chemical Engineering at the University of Houston in 2020 and earned his B.S. in Chemical Engineering from Osmania University in India in 2019. His doctoral research in the SimBioSys Lab at Northeastern University focuses on developing physics-informed computational tools that combine molecular dynamics (MD) simulations and machine learning to predict molecular properties and guide the design of high-affinity antibodies\, work conducted in direct collaboration with Amgen’s Pivotal Attribute Sciences team. Natesan has gained significant industry experience through internships at Amgen\, where he modeled antibody-receptor interfaces and developed GPU-accelerated simulation pipelines\, and at Prescient Design (Genentech)\, where he built multi-modal biological data frameworks to inform therapeutic design decisions. He has authored one first-author manuscript in Protein Science\, has two manuscripts under review\, and has presented his research at over five national conferences\, including BPS\, AIChE\, and ACS. He is also the creator of F.A.D.E (Fully Agentic Drug Engine)\, a prize-winning integrated modelling framework recognized at the Broad Institute ML Symposium and selected for presentation at ACS SciMix and ACS COMP. Beyond his research\, Natesan is an active leader in his academic community. He founded the Northeastern Biophysical Society student chapter and served as its President in 2025. He also served as a Treasurer of the ChemE Graduate Student Council. He has been recognized with numerous honours\, including the LEADERs Fellowship\, NSF ACCESS Award\, multiple travel grants and recognition from both the Department of Chemical Engineering and the University.
URL:https://coe.northeastern.edu/event/che-phd-dissertation-defense-natesan-mani/
LOCATION:409 Robinson Hall\, 360 Huntington Ave\, 409 RB\, Boston\, MA\, 02115\, United States
GEO:42.3401758;-71.0892797
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=409 Robinson Hall 360 Huntington Ave 409 RB Boston MA 02115 United States;X-APPLE-RADIUS=500;X-TITLE=360 Huntington Ave\, 409 RB:geo:-71.0892797,42.3401758
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20260630T100000
DTEND;TZID=America/New_York:20260630T110000
DTSTAMP:20260527T134021Z
CREATED:20260527T134021Z
LAST-MODIFIED:20260527T134021Z
UID:56643-1782813600-1782817200@coe.northeastern.edu
SUMMARY:Crafting Data Visuals to Tell a Scientific Story: CommLab Drop-In Hours
DESCRIPTION:Looking to illustrate your data? Join the CommLab Data Visualization Drop-In sessions Tuesdays from 10-11am on Zoom to discuss strategies or receive feedback on your data visualization process.
URL:https://coe.northeastern.edu/event/crafting-data-visuals-to-tell-a-scientific-story-commlab-drop-in-hours-2/2026-06-30/
END:VEVENT
END:VCALENDAR