Sidi A. Bencherif

Assistant Professor,  Chemical Engineering
Affiliated Faculty,  Bioengineering

Contact

Office

  • 336 Mugar
  • 617.373.7103

Lab

  • 111 Mugar

Research Focus

polymer chemistry and engineering; biomaterials; biomedical engineering; drug delivery; tissue engineering; regenerative medicine; immunotherapy; immunoengineering; vaccines

About

Joined the Chemical Engineering Department in Fall 2016.

Education

  • 2009 PhD in Chemistry, Carnegie Mellon University
  • 2009 MS in Polymer Science, Carnegie Mellon University
  • 1999 B.S. in Physics and Chemistry from University of Montpellier II, France

Professional Affiliations

  • American Chemical Society (ACS)
  • Materials Research Society (MRS)
  • Society for Biomaterials (SFB)
  • Biomedical Engineering Society (BMES)
  • American Association of Immunologists (AAI)
  • Scientific Research Society (Sigma Xi)
  • American Association for Cancer Research (AACR)
  • American Institute of Chemical Engineers (AIChE)

Research Overview

polymer chemistry and engineering; biomaterials; biomedical engineering; drug delivery; tissue engineering; regenerative medicine; immunotherapy; immunoengineering; vaccines

Antimicrobial Biomaterials.

Laboratory for Advanced and Multifunctional Polymeric Biomaterials

The overall focus of the research in the Bencherif LAMP Biomaterials Laboratory is the fundamental understanding and development of polymeric materials for biomedical applications with a specific emphasis on tissue engineering, drug delivery, and cancer immunotherapy.

Bencherif Laboratory

Selected Research Projects

College Research Initiatives

Selected Publications

  • T. Colombani, L.J. Eggermont, Z.J. Rogers, L. McKay, L. Avena, R. Johnson, N. Storm, A. Griffiths, S.A. Bencherif. (2021). Biomaterials and Oxygen Join Forces to Shape the Immune Response and Boost SARS-CoV-2 Vaccines. Advanced Science, 10.1002/advs.202100316
  • T. Colombani, S.M. Hatfield, M. Rezaeeyazdi, L.J. Eggermont, A. Memic, M.V. Sitkovsky, S.A. Bencherif. (2021). Oxygen-generating Cryogels Restore T Cell-Mediated Antitumor Cytotoxicity in Hypoxic Tumor. Advanced Functional Materials, 10.1002/adfm.202102234
  • L.J. Eggermont, T. Colombani, Z.J. Rogers, A. Memic, S.A. Bencherif, Injectable Cryogels for Biomedical Applications, Trends in Biotechnology, 38, 2020, 418–431
  • P. Villard, M. Rezaeeyazdi, T. Colombani, K. Joshi Navare, D. Rana, A. Memic, S.A. Bencherif, Autoclavable and Injectable Cryogels for Biomedical Applications, Advanced Healthcare Materials, 8, 2019, 1900679
  • A. Memic, T. Colombani, M. Rezaeeyazdi, L. Eggermont, J. Steingold, Z. Rogers, K.J. Navare, H.S. Mohammed, M. Sitkovsky, S.A. Bencherif, Latest Advances in Cryogel Technology for Biomedical Applications, Advanced Therapeutics, 2019, 1800114
  • S.A. Bencherif, R.W. Sands, O. Ali, S.A. Lewin, A. Li, T. Braschler, T. Shih, D. Bhatta, G. Dranoff, D.J. Mooney Injectable Scaffold-Based Whole Tumor Cell Vaccines, Nature Communications, 6, 2015, 7556
Lauren Gerbereux

Students

Oct 08, 2021

Lauren Gerbereux Selected as Future Leader in Chemical Engineering

Chemical Engineering student Lauren Gerbereux, E’21, was selected for the 2021 Future Leaders in Chemical Engineering Symposium organized by North Carolina State University.

Bencherif research on cover of Advanced Science.

Faculty

Sep 27, 2021

Bencherif’s Research Featured on Front Cover of Advanced Science

ChE Assistant Professor Sidi A. Bencherif’s research on “Biomaterials and Oxygen Join Forces to Shape the Immune Response and Boost COVID-19 Vaccines” was featured on the front cover of Advanced Science.

Boting Li

Spotlight Story

Sep 21, 2021

Bioengineering Master’s Alumna is Lead Co-Author of Research Paper Published on Cover of Tissue Engineering Part A Journal

While conducting research, Boting Li, ME’19, bioengineering, harvested biomaterials from Assistant Professor Sidi Bencherif’s lab and cell cultures from Assistant Professor Ambika Bajpayee’s lab to create a model to rebuild tissues caused by cartilage defects. While working on this project she developed a more effective protocol to harvest cells from bovine tissue. Her work to her becoming the lead co-author on a paper that was published in the June 2021 issue of Tissue Engineering Part A and featured on its cover.

Cover image of Advanced Functional Materials.

Faculty

Sep 21, 2021

Bencherif’s Research Featured on Cover of Advanced Functional Materials

ChE Assistant Professor Sidi A. Bencherif’s research on “Oxygen-Generating Cryogels Restore T-Cell Mediated Cytotoxicity in Hypoxic Tumors” is featured on the cover of the latest issue of Advanced Functional Materials.

Sidi A. Bencherif

Faculty

Aug 12, 2021

Developing Biomaterial-based Vaccines for Cancer Immunotherapy

ChE Assistant Professor Sidi A. Bencherif received a $2M R01 grant from the National Institutes of Health for “Overcoming vaccine-associated hypoxia with advanced biomaterials to enhance cancer immunotherapy.“

Bencherif working in a lab.

Faculty

Aug 12, 2021

Research to Boost COVID-19 Vaccines Published in ‘Advanced Science’

Could there be an even more effective vaccine? This professor thinks so. Main photo: Existing COVID-19 vaccines have far surpassed public health officials’ expectations. But could they be improved upon even further? Yes, says Sidi Bencherif, assistant professor of chemical engineering at Northeastern. Here’s how. Photo by Adam Glanzman/Northeastern University The COVID-19 vaccines currently authorized […]

Joyce Shen

Aug 09, 2021

Undergraduate Student in Bencherif Lab Wins Honors Early Research Award

Joyce Shen, S’23, a third-year biochemistry undergraduate student in the Bencherif Lab, was recently awarded an Honors Early Research Award for her work on the project “Engineering Polyester-coated Nanoparticles for Extended Oxygen Release.”

Microscopy images depicting the ability of O2-cryogels to restore OT-1 (red, T cells) cytotoxic activity and kill B16-OVA tumor cells (green) under immunosuppressive hypoxic conditions (~1% O2).

Faculty

Jul 26, 2021

Bencherif Publishes “Oxygen-Generating Cryogels Restore T Cell Mediated Cytotoxicity in Hypoxic Tumors” in Advanced Functional Materials

ChE Postdoctoral Research Associate Thibault Colombani (lead author), Loek Eggermont, Stephen Hatfield, Zachary Rogers, PhD’23, Mahboobeh Rezaeeyazdi, PhD’19, Adnan Memic, Michail Sitkovsky, and Assistant Professor Sidi A. Bencherif) published their article Oxygen-Generating Cryogels Restore T Cell Mediated Cytotoxicity in Hypoxic Tumors in the Advanced Functional Materials journal.

cover of Tissue Engineering Part A journal

Faculty

Jun 23, 2021

COE Research Featured on Cover of Tissue Engineering Part A

Research from Assistant Professors Sidi A. Bencherif (ChE) and Ambika G. Bajpayee (BioE) on “Hyaluronic Acid-Based Shape-Memory Cryogel Scaffolds for Focal Cartilage Defect Repair” was featured on the cover of the June 2021 Tissue Engineering Part A journal.

biomaterials science cover

Faculty

Jun 17, 2021

Bencherif’s Research Featured on the Front Cover of Biomaterials Science

ChE Assistant Professor Sidi A. Bencherif’s research on “Engineering a macroporous fibrin-based sequential interpenetrating polymer network for dermal tissue engineering” was featured on the front cover of Biomaterials Science.

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