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Jiahe Li

Assistant Professor,  Bioengineering



  • 225 ISEC
  • 617.373.3233

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Research Focus

Oral vaccine, host and oral microbiome interactions, microbiome engineering, and protein engineering-based cancer immunotherapy


  • Post-doc, David Koch Institute of Integrative Cancer, Massachusetts Institute of Technology
  • PhD, Biomedical Engineering, Cornell University
  • BS, Biochemistry, China Agricultural University

Honors & Awards

  • 2016 David Koch Institute Quinquennial Postdoctoral Fellowship
  • 2018 Peer Reviewed Medical Research Program Discovery Award, Department of Defense

Professional Affiliations

  • Biomedical Engineering Society
  • American Institute of Chemical Engineers
  • American Chemical Society

Research Overview

Oral vaccine, host and oral microbiome interactions, microbiome engineering, and protein engineering-based cancer immunotherapy

Department Research Areas

Selected Publications

  • Wu C, Li J, Wang W, Hammond PT. Rationally Designed Polycationic Carriers for Potent Polymeric siRNA-Mediated Gene Silencing. ACS Nano. 2018 Jun 28. doi: 10.1021/acsnano.7b08777. [Epub ahead of print] PubMed PMID: 29944833.
  • Li J, Wu C, Wang W, He Y, Elkayam E, Joshua-Tor L, Hammond PT. Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2696-E2705. PMID: 29432194
  • Li J, He Y, Wang W, Wu C, Hong C, Hammond PT. Polyamine-Mediated Stoichiometric Assembly of Ribonucleoproteins for Enhanced mRNA Delivery. Angewandte Chemie (International ed. in English). 2017; 56(44):13709-13712. PubMed PMID: 28925033.
  • Li J, Wang W, He Y, Li Y, Yan EZ, Zhang K, Irvine DJ, Hammond PT. Structurally Programmed Assembly of Translation Initiation Nanoplex for Superior mRNA Delivery. ACS Nano. 2017 Mar 28;11(3):2531-2544. PubMed PMID: 28157292.
  • Li J, Ai Y, Wang L, Bu P, Sharkey CC, Wu Q, Wun B, Roy S, Shen X, King MR. Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles. Biomaterials. 2016 Jan;76:52-65. PMCID: PMC4662903.
  • Li J, Sharkey CC, Wun B, Liesveld JL, King MR. Genetic engineering of platelets to neutralize circulating tumor cells. J Control Release. 2016 Apr 28;228:38-47. PMCID: PMC4828270.
Portraits of Bajpayee and Li


Aug 20, 2019

Bajpayee Awarded NIH Trailblazer R21 Grant

BioE Assistant Professor Ambika Bajpayee(PI) and Jiahe Li (co-PI) were awarded a $628K NIH Trailblazer grant from the National Institute of Biomedical Imaging and Bioengineering for “Anti-Catabolic Drug Anchored Cationic Exosomes For Cartilage Targeting And Repair”.


Apr 09, 2019

FY20 TIER 1 Award Recipients

25 COE faculty and affiliates were recipients of FY20 TIER 1 Interdisciplinary Research Seed Grants for 18 different projects representing up to $900K dollars of investment in research.


Jan 04, 2019

New Faculty Spotlight: Jiahe Li

Jiahe Li joins the Bioengineering department in January 2019 as an Assistant Professor.

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