Jiahe Li
Assistant Professor, Bioengineering
Contact
- jiah.li@northeastern.edu
- 360 Huntington Avenue
Boston, Massachusetts 02115
Office
- 225 ISEC
- 617.373.3233
Related Links
Research Focus
Oral vaccine, host and oral microbiome interactions, microbiome engineering, and protein engineering-based cancer immunotherapy
Education
- Post-doc, David Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 2015-2018
- PhD, Biomedical Engineering, Cornell University, 2009-2015
- BS, Microbiology, China Agricultural University, 2005-2009
Honors & Awards
- 2016 David Koch Institute Quinquennial Postdoctoral Fellowship
- 2018 Peer Reviewed Medical Research Program, Discovery Award, Department of Defense
- 2020 Peer Reviewed Medical Research Program, Discovery Award, Department of Defense
- 2020 Peer Reviewed Cancer Research Program, Idea Award, Department of Defense
Teaching Interests
BioE 3210 Bioelectricity
Professional Affiliations
- Biomedical Engineering Society
- American Institute of Chemical Engineers
- American Chemical Society
Research Overview
Oral vaccine, host and oral microbiome interactions, microbiome engineering, and protein engineering-based cancer immunotherapy
Selected Research Projects
- Research Capability Grant
- – Principal Investigator, Research and Innovation Agency at the Ministry of Education in Saudi Arabia
- Cancer Drug Development Award
- – Principal Investigator, Dana-Farber Cancer Institute/ Northeastern University
Department Research Areas
Selected Publications
After transitioning to the PI in 2019
- Sun X, Ni Y, He Y, Yang M, , , Li J*. Engineering the Immune Adaptor Protein STING as a Biologic, Biorxiv. https://www.biorxiv.org/content/10.1101/2021.02.18.431824v1
- He Y, Hong C, Irvine DJ, Li J*, Hammond PT*. In vitro STING Activation with the cGAMP-STINGΔTM Signaling Complex, Bio-protocol, 2021. https://bio-protocol.org/e3905
- Zhao H, Li T, Gu Z, Liu C, Li J, Yang D. Intralysosomal environment-responsive metal-organic framework for microRNA delivery and synergetic gene/chemodynamic therapy of triple-negative breast cancer, ACS Applied Materials & Interfaces, 2021. https://pubs.acs.org/doi/abs/10.1021/acsami.0c21006
- Zhang X, Al-Dossary A, Hussain M, Setlow P, Li J*. Applications of Bacillus subtilis Spores in Biotechnology and Advanced Materials, Applied and Environmental Microbiology, 2020. https://aem.asm.org/content/early/2020/06/29/AEM.01096-20
- He Y, Hong C, Yan Z.E, Li Y, Zhu G, Yang M, Li Y, Sun X, Irvine DJ, Li J*, Hammond PT*. Self-Assembled cGAMP-STING ΔTM Signaling Complex as a Bioinspired Platform for cGAMP Delivery, Science Advances, 2020. https://advances.sciencemag.org/content/6/24/eaba7589
- Yang M, Zhu G, George K, Sun X, Setlow P, Li J*. Engineering Bacillus subtilis as a Versatile and Stable Platform for Production of Nanobodies, Applied and Environmental Microbiology, 2020 Apr 1;86(8). https://aem.asm.org/content/86/8/e02938-19
Before transitioning to the PI in 2019
- Ludwicki MB, Li J, Stephens EA, Roberts RW, Koide S, Hammond PT, DeLisa MP. Broad-Spectrum Proteome Editing with an Engineered Bacterial Ubiquitin Ligase Mimic. ACS Cent Sci. 2019 May 22;5(5):852-866.
- Li J, He Y, Wang W, Wu C, Hong C, Hammond PT. Polyamine-Mediated Stoichiometric Assembly of Ribonucleoproteins for Enhanced mRNA Delivery. Angewandte Chemie (International ed. in English). 2017; 56(44):13709-13712.
- Li J, Wang W, He Y, Li Y, Yan EZ, Zhang K, Irvine DJ, Hammond PT. Structurally Programmed Assembly of Translation Initiation Nanoplex for Superior mRNA Delivery. ACS Nano. 2017 Mar 28;11(3):2531-2544.
Oct 16, 2020
COE Faculty Awarded Seed Funding in Collaboration with University of Maine
BioE Assistant Professors Jiahe Li and Mingyang Lu, ECE Professor & Chair Srinivas Tadigadapa, ECE Assistant Professors Sarah Ostadabbas and Xue “Shelley” Lin, and ECE Associate Research Scientist Ataur Katebi were among the faculty chosen for five competitive collaborative research projects with the University of Maine in the areas of artificial intelligence, earth and climate sciences, health and life sciences, manufacturing, and marine sciences.
Oct 01, 2020
Assuring that Self-Driving Cars are Accessible to Those with Disabilities
ECE Assistant Professor Xue “Shelley” Lin is working with the algorithms in self-driving vehicles to ensure that they will be accessible to those with disabilities.
Apr 11, 2020
FY21 TIER 1 Award Recipients
Congratulations to the 19 COE faculty and affiliates who were recipients of FY21 TIER 1 Interdisciplinary Research Seed Grants for 13 different projects.
Aug 20, 2019
Bajpayee Awarded NIH Trailblazer R21 Grant
BioE Assistant Professor Ambika Bajpayee(PI) and Jiahe Li (co-PI) were awarded a $628K NIH Trailblazer grant from the National Institute of Biomedical Imaging and Bioengineering for “Anti-Catabolic Drug Anchored Cationic Exosomes For Cartilage Targeting And Repair”.
Apr 09, 2019
FY20 TIER 1 Award Recipients
25 COE faculty and affiliates were recipients of FY20 TIER 1 Interdisciplinary Research Seed Grants for 18 different projects representing up to $900K dollars of investment in research.
Jan 04, 2019
New Faculty Spotlight: Jiahe Li
Jiahe Li joins the Bioengineering department in January 2019 as an Assistant Professor.