Jiahe Li

Assistant Professor,  Bioengineering


  • jiah.li@northeastern.edu
  • For package delivery by UPS, USPS or Fedex: Jiahe Li (ISEC 225), 360 Huntington Avenue, Boston, MA, 02115

    For visiting our lab: ISEC 225, 805 Columbus Ave, Boston, MA, 02115


  • 225 ISEC
  • 617.373.3233

Research Focus

Oral vaccine, host and oral microbiome interactions, microbiome engineering, and protein engineering-based cancer immunotherapy


  • Post-doc, David Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 2015-2018
  • PhD, Biomedical Engineering, Cornell University, 2009-2015
  • BS, Microbiology, China Agricultural University, 2005-2009

Honors & Awards

  • 2023 NSF CAREER
  • 2021 NIBIB Trailblazer Award
  • 2021 Peer Reviewed Cancer Research Program, Idea Award, Department of Defense
  • 2020 Peer Reviewed Medical Research Program, Discovery Award, Department of Defense
  • 2018 Peer Reviewed Medical Research Program, Discovery Award, Department of Defense
  • 2016 David Koch Institute Quinquennial Postdoctoral Fellowship

Teaching Interests

BioE 3210 Bioelectricity

BioE 5820 Biomaterials


Professional Affiliations

  • Biomedical Engineering Society
  • American Institute of Chemical Engineers
  • American Chemical Society

Research Overview

Oral vaccine, host and oral microbiome interactions, microbiome engineering, and protein engineering-based cancer immunotherapy

The Advanced Therapeutics Lab

The Li research group in the Department of Bioengineering at Northeastern University focuses on the development of molecular and live cell-based therapeutics, with a major emphasis on the use of bioconjugation chemistry, synthetic biology, and microbiology to interrogate and manipulate interactions between therapeutics, the microbiome, and host.

Li Lab

Selected Research Projects

College Research Initiatives

Selected Publications

After transitioning to the PI in 2019

Before transitioning to the PI in 2019

  • Ludwicki MB, Li J, Stephens EA, Roberts RW, Koide S, Hammond PT, DeLisa MP. Broad-Spectrum Proteome Editing with an Engineered Bacterial Ubiquitin Ligase Mimic. ACS Cent Sci. 2019 May 22;5(5):852-866.
  • Li J, He Y, Wang W, Wu C, Hong C, Hammond PT. Polyamine-Mediated Stoichiometric Assembly of Ribonucleoproteins for Enhanced mRNA Delivery. Angewandte Chemie (International ed. in English). 2017; 56(44):13709-13712.
  • Li J, Wang W, He Y, Li Y, Yan EZ, Zhang K, Irvine DJ, Hammond PT. Structurally Programmed Assembly of Translation Initiation Nanoplex for Superior mRNA Delivery. ACS Nano. 2017 Mar 28;11(3):2531-2544.
Jiahe Li


Jan 18, 2023

NSF CAREER Award for Examining sRNAs as Potential Disease Prevention

Jiahe Li, BioE assistant professor, has been awarded a $636,000 National Science Foundation (NSF) CAREER Award, titled “Understanding and Harnessing Host-derived Small RNAs Against Opportunistic Pathogens,” to learn how to harness one of the body’s natural defense mechanisms to inhibit bad bacteria.

Jiahe Li


Jul 21, 2022

Li Receives Grant to Protect Against Poultry Diseases

The laboratory of BioE Assistant Professor JIahe Li received an industry grant from Eco Animal Science in the United Kingdom, one of the largest global animal health companies, to develop genetically modified probiotics against enteric diseases in poultry.


Oct 12, 2021

Announcing Fall 2021 PEAK Experiences Awardees

Several engineering students and science students mentored by COE faculty are recipients of Northeastern’s Fall 2021 PEAK Experiences Awards. The PEAK Experiences Awards are a progressively structured sequence of opportunities designed to support learners as they continue climbing to new heights of achievement in undergraduate research and creative endeavor throughout their Northeastern journeys. ASCENT AWARDS […]


Oct 16, 2020

COE Faculty Awarded Seed Funding in Collaboration with University of Maine

BioE Assistant Professors Jiahe Li and Mingyang Lu, ECE Professor & Chair Srinivas Tadigadapa, ECE Assistant Professors Sarah Ostadabbas and Xue “Shelley” Lin, and ECE Associate Research Scientist Ataur Katebi were among the faculty chosen for five competitive collaborative research projects with the University of Maine in the areas of artificial intelligence, earth and climate sciences, health and life sciences, manufacturing, and marine sciences.

steering wheel and dashboard of self-driving car


Oct 01, 2020

Assuring that Self-Driving Cars are Accessible to Those with Disabilities

ECE Assistant Professor Xue “Shelley” Lin is working with the algorithms in self-driving vehicles to ensure that they will be accessible to those with disabilities.


Apr 11, 2020

FY21 TIER 1 Award Recipients

Congratulations to the 19 COE faculty and affiliates who were recipients of FY21 TIER 1 Interdisciplinary Research Seed Grants for 13 different projects.

Portraits of Bajpayee and Li


Aug 20, 2019

Bajpayee Awarded NIH Trailblazer R21 Grant

BioE Assistant Professor Ambika Bajpayee(PI) and Jiahe Li (co-PI) were awarded a $628K NIH Trailblazer grant from the National Institute of Biomedical Imaging and Bioengineering for “Anti-Catabolic Drug Anchored Cationic Exosomes For Cartilage Targeting And Repair”.


Apr 09, 2019

FY20 TIER 1 Award Recipients

25 COE faculty and affiliates were recipients of FY20 TIER 1 Interdisciplinary Research Seed Grants for 18 different projects representing up to $900K dollars of investment in research.


Jan 04, 2019

New Faculty Spotlight: Jiahe Li

Jiahe Li joins the Bioengineering department in January 2019 as an Assistant Professor.

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