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EXPLORE NORTHEASTERN

Shashi Murthy

Professor,  Chemical Engineering
Affiliated Faculty,  Mechanical and Industrial Engineering

Contact

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Office

  • 313 SN
  • 617.373.4017

Research Focus

Microfluidic isolation of stem and progenitor cells, point-of-care diagnostics, cell surface phenomena during microfluidic flow, nanoscale probes for cell stimulation, and biopassive/bioactive coatings for neurological implants

About

Joined the Chemical Engineering Department in Fall 2005.

The primary focus of our research is the design of microfluidic devices for applications in clinical diagnostics and regenerative medicine. These devices are fabricated using technology originally designed for the semiconductor industry and are capable of handling and manipulating small volumes of fluids (down to tens of microliters) and small numbers of cells. Our expertise is in functionalizing microfluidic channels with a broad range of biomolecules and achieving high-resolution cell separation with these simple and easy-to-use devices.

Education

  • B.S. (Chemical Engineering) Johns Hopkins University, 1999
  • Ph.D. (Materials Science and Engineering) Massachusetts Institute of Technology, 2003
  • Postdoctoral Fellowship Harvard Medical School and Massachusetts General Hospital, 2003-2005

Honors & Awards

  • 2014 COE Faculty Fellow
  • National Science Foundation CAREER Award
  • Søren Buus Outstanding Research Award

Research Overview

Microfluidic isolation of stem and progenitor cells, point-of-care diagnostics, cell surface phenomena during microfluidic flow, nanoscale probes for cell stimulation, and biopassive/bioactive coatings for neurological implants

Department Research Areas

Selected Publications

  • A. Kozbial, L. Bhandary, B.B. Collier, C.S. Eickhoff, D.F. Hoft, S.K. Murthy, Automated Generation of Immature Dendritic Cells in a Single Use System, Journal of Immunological Methods 2018, 457, 53-65
  • H. Sallmon, A. Hatch, S.K. Murthy, B.D. Plouffe, G. Hansmann, Circulating Endothelial Cell Quantification by Microfluidics Chip in Pulmonary Arterial Hypertension, American Journal of Respiratory Cell and Molecular Biology 2017, 56, 680-682
  • T. Narahari, D. Dendukuri, and S.K. Murthy, Electrically-Actuated Valves for Woven Fabric Lateral Flow Devices, Analytical Chemistry 2017, 89, 4671-4679
  • D.I. Walsh, D.S. Kong, S.K. Murthy, P.A. Carr, Enabling Microfluidics: From Clean Rooms to Makerspaces,” Trends in Biotechnology 2017, 35, 383-392.
  • B.D. Plouffe and S.K. Murthy, Fluorescence-Based Lateral Flow Assays for Rapid Oral Fluid Roadside Detection of Cannabis Use, Electrophoresis 2017, 38, 501-5016
  • D.I. Walsh, S.K. Murthy, A. Russom, Ultra-High-Throughput Sample Preparation System for Lymphocyte Immunophenotyping Point-of-Care Diagnostics, Journal of Laboratory Automation 2016

Alumni

Oct 17, 2018

Changing the Way We Treat Cancer

Quad Technologies, which was co-founded by ChE Professor Shashi Murthy, Sean Kevlahan (PhD ’13), Adam Hatch (PhD ’14), and Brian Plouffe (PhD ’11), and recently acquired by Bio-Techne, has developed a material, called QuickGel, that can be used to isolate genetically engineered T-cells that would allow a patient’s immune system to target the cancer.

Alumni

Jun 13, 2018

Bio-Techne To Acquire Quad Technologies

Bio-Techne will acquire the spinout company Quad Technologies, which was co-founded by ChE Professor Shashi Murthy, Sean Kevlahan (PhD ’13), Adam Hatch (PhD ’14), and Brian Plouffe (PhD ’11).

Faculty

May 01, 2018

Faculty and Staff Awards 2018

Congratulations to all the winners of the faculty and staff awards, and to everyone for their hard work and dedication during the 2017-2018 academic school year.

Faculty

Apr 02, 2018

Compositions and Methods of Using Alginic Acid Hydrogels

ChE Professor Shashi Murthy and PhD Adam Hatch were awarded a patent for his “Methods, compositions and devices employing alginic acid hydrogels for highly specific capture and release of biological materials”.

Faculty

Jan 17, 2018

Quad Technologies Partners With Sartorius Stedim Biotech On CD3/CD28 T Cell Activation Product

Quad Technologies, which was co-founded by ChE Professor Shashi Murthy, Sean Kevlahan (PhD ’13), Adam Hatch (PhD ’14), and Brian Plouffe (PhD ’11), was featured in BusinessWire's article "Quad Technologies Partners With Sartorius Stedim Biotech On CD3/CD28 T Cell Activation Product" announcing their new strategic partnership with global leader in bioprocess technologies, Sartorius Stedim Biotech.

Faculty

Jan 09, 2017

Generate Helps Students with Start-Ups

Northeastern's student-led product development studio, Generate, helps with product development and the business integration required to get create a start-up.

Alumni

Nov 10, 2016

Chemical Engineering Alumni Present Capstone Project “DendriNow” at AIChE San Francisco

Last Spring, a Chemical Engineering capstone team consisting of Jennifer Langh ChE'16, Melanie Guerin ChE'16, Robert Kuhn ChE'16, and Grant Levy ChE'16 were looking for inspiration. They wanted to find a capstone project that could produce something tangible, as opposed to the typical theoretical nature of these projects. They were rewarded with an opportunity to […]

Oct 07, 2016

Murthy Awarded $300K NSF Grant

ChE Professor Shashi Murthy was awarded a $300K NSF grant to create a "Bioreactor System for Autologous T-Cell Stimulation".

Sep 02, 2016

Shashi Murthy Wins NSF Grant for Cell Therapy Manufacturing with Neon Therapeutics

Chemical Engineering Professor Shashi Murthy has received funding from the National Science Foundation to develop novel manufacturing technologies for cell-based cancer therapies.  This project will be a collaborative effort with Cambridge, MA-based Neon Therapeutics which is developing neo-antigen-based therapeutic vaccines and cell-based therapies for cancer.  Cell-based therapies represent the next major frontier in the treatment […]

Dec 17, 2015

Shashi Murthy Elected Fellow of AIMBE

ChE Professor Shashi Murthy has been elected a Fellow of the American Institute for Medical and Biological Engineering for outstanding contributions to the science and technology of cell purification for therapeutic and analytical applications.

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