Harikrishnan Parameswaran

Assistant Professor,  Bioengineering

Contact

Office

  • 617.373.7049

Research Focus

Mechanobiology of the smooth muscle, Mechanisms of force transmission in multicellular ensembles, Methods for targeting extracellular matrix for asthma therapy

About

Joined the Bioengineering department in January 2017.

Education

  • PhD, Boston University, 2009

Honors & Awards

Research Overview

Mechanobiology of the smooth muscle, Mechanisms of force transmission in multicellular ensembles, Methods for targeting extracellular matrix for asthma therapy

Selected Research Projects

  • Extracellular Determinants of Airway Smooth Muscle Force: A New Paradigm for Sustained Airway Constriction
    • – Principal Investigator, R00 Award, National Institutes of Health

Selected Publications

  • D.A. Vargas, T. Heck, B. Smeets, H. Ramon, H. Parameswaran, H. Van Oosterwyck Intercellular Adhesion Stiffness Moderates Cell Decoupling as a Function of Substrate Stiffness, Biophysical Journal, 2020
  • S.E. Stasiak, R.R. Jamieson, J. Bouffard, E.J. Cram, H. Parameswaran, Intercellular Communication Controls Agonist-Induced Calcium Oscillations Independently of Gap Junctions in Smooth Muscle Cells, Science Advances, 6(32),2020
  • J.R. Mondoñedo, S. Sato, T. Oguma, S. Muro, A.H. Sonnenberg, D. Zeldich, H. Parameswaran, T. Hirai, B. Suki, CT Imaging-Based Low-Attenuation Super Clusters in Three Dimensions and the Progression of Emphysema, Chest, 155(1), 2019, 79-87
  • S.R. Polio, S.E. Stasiak, R.R. Jamieson, J.L. Balestrini, R. Krishnan, H. Parameswaran, Extracellular Matrix Stiffness Regulates Human Airway Smooth Muscle Contraction by Altering the Cell-Cell Coupling, Scientific Reports, 9, 2019, 9564
  • J. Imsirovic, E. Bartolák-Suki, S.B. Jawde, H. Parameswaran, B. Suki, Blood Pressure-Induced Physiological Strain Variability Modulates Wall Structure and Function in Aorta Rings, Physiological Measurement, 39(10), 2018, 105014
  • H. Parameswaran, B. Suki, Assessing Structure-Function Relations in Mice Using the Forced Oscillation Technique and Quantitative Histology, Methods in Molecular Biology, 1639, 2017, 77-91
  • S.M. Cloonan, K. Glass, A.R. Bhashyam, M.E. Laucho Contreras, H. Parameswaran, et al., Mitochondrial Iron Chelation Ameliorates Cigarette Smoke-Induced Bronchitis and Emphysema in Mice, Nature Medicine, 22, 2016, 163-174

Faculty

Mar 30, 2021

Parameswaran Receives NSF CAREER Award

BioE Assistant Professor Harikrishnan Parameswaran received a $600K CAREER award for “Elucidating the Role of Collective Cell-Matrix Interactions in the Mechanobiology of Airway Narrowing.”

Students

Feb 08, 2021

Spring 2021 PEAK Experience Recipients

Congratulations to the COE student recipients of the Spring 2021 PEAK Experiences Awards. The PEAK Experiences Awards are a progressively structured sequence of opportunities designed to support learners as they continue climbing to new heights of achievement in undergraduate research and creative endeavor throughout their Northeastern journeys. PEAK Experience Ascent Awardees Ryan Brady, COE’22, Chemical […]

Faculty

Aug 17, 2020

Research on Extracellular Matrix Making Waves for Asthma Therapy

BioE Assistant Professor Harikrishnan Parameswaran’s research on “Intercellular communication controls agonist-induced calcium oscillations independently of gap junctions in smooth muscle cells” was published in Science Advances.

Faculty

Apr 09, 2019

FY20 TIER 1 Award Recipients

25 COE faculty and affiliates were recipients of FY20 TIER 1 Interdisciplinary Research Seed Grants for 18 different projects representing up to $900K dollars of investment in research.

Faculty

Jan 20, 2017

New Faculty Spotlight: Harikrishnan Parameswaran

Harikrishnan Parameswaran joins the Bioengineering department in January 2017 as an Assistant Professor.

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