Penny Beuning
Affiliated Faculty, Bioengineering
Professor, Chemistry and Chemical Biology
Contact
- p.beuning@northeastern.edu
- 06 Hurtig Hall
360 Huntington Avenue
Boston, MA 02115
Office
- 617.373.2865
Related Links
Research Focus
chemical biology and biotechnology; DNA replication and repair; enzyme function
Education
2000 Ph.D. University of Minnesota
1994 B.A. Macalester College, St. Paul, Minnesota
Honors & Awards
- 2021, IMPACT Award, Research Corporation for Science Advancement
- 2020, Fellow, American Chemical Society
- 2012, American Cancer Society Research Scholar Award
- 2009, National Science Foundation CAREER Award
- 2009, Cottrell Scholar Award
- Chemical Research in Toxicology Young Investigator Award, American Chemical Society
Research Overview
chemical biology and biotechnology; DNA replication and repair; enzyme function
Selected Research Projects
- D3SC: Mining For Mechanistic Information to Predict Protein Function
- – Co-Principal Investigator, National Science Foundation
- Dynamics of Processivity Clamp Proteins in Bacterial DNA Replication
- – Principal Investigator, National Institutes of Health
Selected Publications
- Strezsak, Steven R., Beuning, Penny J., Skizim, Nicholas J. (2021) Complete Enzymatic Digestion of Double-Stranded RNA to Nucleosides Enables Accurate Quantification of dsRNA. Analytical Methods 13, 179-185. 10.1039/D0AY01498B
- Naufer, M. Nabuan, Morse, Michael, Björg Möller, Guðfríður, McIsaac, James, Rouzina, Ioulia, Beuning, Penny J., Williams, Mark C. (2021) Multiprotein E. coli SSB-ssDNA complex show both stable binding and rapid dissociation due to interprotein interactions. Nucleic Acids Research 49, 1532-1549. 10.1039/nar/gkaa1267
- L. Ngu, J.N. Winters, K. Nguyen, K.E. Ramos, N.A. DeLateur, L. Makowski, P.C. Whitford, M.J. Ondrechen, P.J. Beuning Probing Remote Residues Important for Catalysis in Escherichia Coli Ornithine Transcarbamoylase, PLoS One 15(2), 2020, e0228487
- K.R. Moulton, A. Sadiki, B.N. Koleva, L.J. Ombelets, T.H. Tran, S. Liu, B. Wang, H. Chen, E. Micheloni, P.J. Beuning, G.A. O’Doherty, Z.S. Zhou, Site-Specific Reversible Protein Modification: Transglutaminase-Catalyzed Glutamine Conjugation and Bioorthogonal Light-Mediated Removal, Bioconjugate Chemistry, 30, 2019, 1617-1621
- N.M. Antczak, A.R. Walker, H.R. Stern, E.M. Leddin, T.A. Coulther, C. Palad, R.J. Swett, G.A. Cisneros, P.J. Beuning, Characterization of Nine Cancer-Associated Variants in Human DNA Polymerase K, Chemical Research in Toxicology, 31, 2018, 697-711
- C.L. Mills, R. Garg, J.S. Lee, L. Tian, A. Suciu, G. Cooperman, P.J. Beuning, M.J. Ondrechen, Functional Classification of Protein Structures by Local Structure Matching in Graph Representation, Protein Science, 27, 2018, 1125-1135
- R. Parasuram, T.A. Coulther, J.M. Hollander, E. Keston Smith, M.J. Ondrechen, P.J. Beuning, Prediction of Active Site and Distal Residues in E. coli DNA Polymerase III Alpha Polymerase Activity, Biochemistry, 57(7), 2018, 1063–1072
![](https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_392,h_200/https://coe.northeastern.edu/wp-content/uploads/ondrechen-erdogmus-beuning.jpg)
Jun 27, 2019
Predicting Protein Functions from 3D Structures
ECE Professor Deniz Erdogmus (co-PI) and affiliated BioE Professors Mary Jo Ondrechen (PI) and Penny Beuning (co-PI) were awarded a $600K NSF grant for “Mining for mechanistic information to predict protein function”.
![](https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_150,h_200/https://coe.northeastern.edu/wp-content/uploads/ruberti-j_0.jpg)
Aug 21, 2018
$1M NSF Grant to Advance the Study of Single-Molecule Research
BioE Professor Jeffrey Ruberti (co-PI) along with bioengineering affiliated and College of Science faculty, including Professor Mark Williams (PI), and Associate Professors Penny Beuning (co-PI), Meni Wanunu (co-PI), and Ke Zhang (co-PI) were awarded a $1M NSF grant for the “Acquisition of a Lumick’s SuperC-TRAP correlative optical tweezers and fluorescence microscope (CTFM) system.”
Mar 22, 2016
FY17 TIER 1 Award Recipients
23 COE faculty and affiliates were recipients of FY17 TIER 1 Interdisciplinary Research Seed Grants for 12 different projects representing over $600K dollars of investment in research.
Apr 06, 2011
FY12 TIER 1 Award Recipients
28 COE faculty and affiliates were recipients of FY12 TIER 1 Interdisciplinary Research Seed Grants for 18 different research projects.