Auguste Awarded Patent for Chemotherapeutic Drug Delivery
![debra auguste](https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_600,h_400/https://coe.northeastern.edu/wp-content/uploads/profiles/che/auguste-d-rect.png)
ChE Professor Debra Auguste was awarded a patent for “Cationic polymers as co-drugs for chemotherapeutic agents”.
Abstract Source: USPTO
A method for treating a biological cell is disclosed. The method administers a mixture of a chemotherapeutic drug and a co-drug that facilitates delivery of the chemotherapeutic drug to the nucleus of the cell. Examples of co-drugs include cationic polymers, cationic lipids and cationic proteins. Cationic polymers include a polyethyleneimine (PEI), polylysine, a polybetaaminoester (PBAE), an ε-polylysine (EPL) including ε-poly-L-lysine (e-PLL), a polyarginine peptide, chitosan, a polyamidoamine dendrimer (PAMAM). Cationic lipids include 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP). Cationic proteins include protamine.