Debra Auguste

Professor,  Chemical Engineering

Contact

Office

  • 327 ISEC
  • 617.373.6243

Lab

  • 360 ISEC

Research Focus

Bioresponsive drug delivery; cell and tissue engineering; tissue architecture; targeted therapeutics

About

Joined the Chemical Engineering Department in Fall 2016.

Education

  • 2005 PhD in Chemical Engineering, Princeton University
  • 1999 SB in Chemical Engineering, MIT

Honors & Awards

  • 2020 American Institute for Medical and Biological Engineering Fellow
  • 2018 Biomedical Engineering Society Fellow
  • 2012 Presidential Early Career Award in Science and Engineering (PECASE)
  • 2012 NIH Director’s New Innovator Award
  • 2011 NSF CAREER Award
  • 2010 Participant, National Academy of Engineering, Frontiers of Engineering Meeting
  • 2010 Named 50 Most Influential African-Americans in Technology
  • 2009 DARPA Young Faculty Award
  • 2007 Office of Naval Research Young Investigator Program Award

Leadership Positions

  • Board of Directors, Biomedical Engineering Society

Professional Affiliations

  • American Chemical Society
  • American Institute of Chemical Engineers
  • Biomedical Engineering Society
  • Materials Research Society

Research Overview

Bioresponsive drug delivery; cell and tissue engineering; tissue architecture; targeted therapeutics

Debra Auguste has designed a drug delivery system that more effectively targets a particularly difficult-to-treat form of breast cancer and keeps it from metastasizing.

Auguste Lab for Bioresponsive Drug Delivery and Tissue Engineering

Our lab engineers solutions to address current challenges in medicine. We design, synthesize, and evaluate new biomaterials that change the way we deliver drugs and cells. These materials exhibit cooperative or heterogeneous features, exemplified in nature.

Lab Website

Selected Publications

  • P. Guo, J. Yang, D. Liu, L. Huang, G. Fell, J. Huang, M.A. Moses, D.T. Auguste, Dual Complementary Liposomes Inhibit Triple-Negative Breast Tumor Progression and Metastasis, Science Advances, 5(3), 2019, eaav5010
  • D.E. Large, J.R. Soucy, J. Hebert, D.T. Auguste, Advances in Receptor-Mediated, Tumor-Targeted Drug Delivery, Advanced Therapeutics, 2018
  • P. Guo, D. Liu, K. Subramanyam, B. Wang, J. Yang, J. Huang D.T. Auguste, M.A. Moses, Nanoparticle Elasticity Directs Tumor Uptake, Nature Communications, 9(130), 2018
  • D. Liu, D.T. Auguste, Peptide Density Targets and Impedes Triple Negative Breast Cancer Metastasis, Nature Communications, 9, 2018, 2612
  • P. Guo, B. Wang, D. Liu, J. Yang, K. Subramanyam, C. McCarthy, J. Hebert, M. Moses, D.T. Auguste, Using Atomic Force Microscopy to Predict Tumor Specificity of ICAM1 Antibody-Directed Nanomedicines, Nano Letters, 18, 2018, 2254-2262
  • P. Guo, J. Yang, D. Jia, M.A. Moses, D.T. Auguste, ICAM-1-Targeted, Lcn2 siRNA-Encapsulated Liposomes are Potent Anti-Angiogenic Agents for Triple Negative Breast Cancer, Theranostics, 6, 2016, 1-13
  • D. Liu, D.T. Auguste, Cancer Targeted Therapeutics: From Molecules to Drug Delivery Vehicles, Journal of Controlled Release, 219, 2015, 632-643
  • B. Wang, P. Guo, D.T. Auguste, Mapping the CXCR4 Receptor on Breast Cancer Cells, Biomaterials, 57, 2015, 161-8
  • T.T. Ho, J.O. You, D.T. Auguste, siRNA Delivery Impedes the Temporal Expression of Cytokine-Activated VCAM1 on Endothelial Cells, Annals of Biomedical Engineering, 2015, 1-8

Undergraduate

Oct 12, 2021

Fall 2021 PEAK Experiences Awardees

Congratulations to the COE student recipients of the Fall 2021 PEAK Experiences Awards. The PEAK Experiences Awards are a progressively structured sequence of opportunities designed to support learners as they continue climbing to new heights of achievement in undergraduate research and creative endeavor throughout their Northeastern journeys. ASCENT AWARDS Shana Broitman, COE’23, “Overcoming STING Silencing […]

Faculty

Apr 20, 2021

FY22 TIER 1 Award Recipients

Congratulations to the 17 COE faculty and affiliates who were recipients of FY22 TIER 1 Interdisciplinary Research Seed Grants for 11 different projects.

In the Media

Feb 01, 2021

1,000 inspiring Black scientists in America

ChE Assistant Professor Andrew Jones, Professor Debra Auguste, Assistant Professor Eno Ebong, and Solomon Mensah (former PhD student of Eno Ebong) were featured in Cell Mentor’s article of “1,000 inspiring Black scientists in America.”

debra auguste

Faculty

Mar 27, 2020

Auguste Selected as AIMBE Fellow

ChE Professor Debra Auguste was selected as an American Institute for Medical and Biological Engineering (AIMBE) Fellow in recognition of “her distinguished and continuing achievements in medical and biological engineering”.

debra auguste

Faculty

Aug 27, 2019

Auguste Awarded Patent for Chemotherapeutic Drug Delivery

ChE Professor Debra Auguste was awarded a patent for “Cationic polymers as co-drugs for chemotherapeutic agents”. Abstract Source: USPTO A method for treating a biological cell is disclosed. The method administers a mixture of a chemotherapeutic drug and a co-drug that facilitates delivery of the chemotherapeutic drug to the nucleus of the cell. Examples of […]

Faculty

Apr 03, 2019

Targeting Triple-Negative Breast Cancer

ChE Professor Debra Auguste is collaborating with Boston Children’s Hospital to develop new treatments to target and treat patients with triple-negative breast cancer.

Faculty

Apr 01, 2019

Auguste Lab Featured on Molecular Pharmaceutics

ChE Professor Debra Auguste’s article on “Targeted Lipid Nanoemulsions Encapsulating Epigenetic Drugs Exhibit Selective Cytotoxicity on CDH1/FOXM1+ Triple Negative Breast Cancer Cells” published in Molecular Pharmaceutics.

Faculty

Mar 21, 2019

Auguste Lab Published in Science Advances

Chemical Engineering Professor Debra Auguste’s research paper, Dual complementary liposomes inhibit triple-negative breast tumor progression and metastasis, was recently published in Sciences Advances journal.

Graduate

Oct 09, 2018

COE NeuroArt Winner

MBF Bioscience recently selected ChE PhD student Danielle Large as a NeuroArt winner and her work was featured on the cover image of the November 2018 issue of the Journal of Neuroscience Research.

Faculty

Sep 25, 2018

Women in Bioconjugate Chemistry

ChE Professor Debra Auguste was featured in the latest Virtual Issue of Bioconjugate Chemistry from ACS (American Chemical Society). The article is titled “Women in Bioconjugate Chemistry: Celebrating Women Scientists”. Read it here: Women in Bioconjugate Chemistry Virtual Issue. “Celebrate the women who are collaborating across disciplines, developing new understanding and new ideas. Celebrate the women […]

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