Institute for Mechanobiology
Northeastern University’s Institute for Mechanobiology accelerates mechanobiology discovery and technology to advance human medicine and health. It is one of only a few in the world specifically dedicated to mechanobiology study and innovation. Ning Wang, professor of bioengineering, is director of the institute, which is made up of faculty experts from the College of Engineering, College of Science, and Bouvé College of Health Sciences.
Widely believed to be the “missing science,” mechanobiology can provide the critical link between a variety of pathologies and their root causes, leading directly to the development of effective therapeutics and prevention strategies for many currently untreatable and debilitating medical conditions.
The institute’s research investigates the role of force and mechanics in biological systems, discovers the root causes of mechanobiological pathologies that negatively affect quality of life, designs interventions and sensors to alter mechanical inputs and biological outputs, and pursues mechanotherapeutics that restore function or slow the progression of diseases.
Initially, the primary mechanobiology research theme is aging, with faculty investigating several interconnected sub-areas, from cardiovascular, musculoskeletal, neurological, and immune systems to mechanotherapeutic technology and methods, to mechanobiological rehabilitation devices, and more. Thoroughly understanding the aging process and its implications for health and well-being is increasingly imperative as the Baby Boom generation grows older. The number of Americans over 65 is projected to reach 80 million in 2040 according to the Urban Institute, with the number of adults 85 and older—the group most often needing help with basic personal care—more than doubling between 2020 and 2040.
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Cellular and molecular mechanobiology, mechanomedicine, and mechanohealth; cancer cell biology and mechanics; stem cell biology and mechanics; mechanomemory and mechanoresilience, mechanobiotechnologies and their applications to cells, tissues, and organisms
Recent News
Cell Nuclear Force Probe Reveals Mechanomemory That May Impact Cell Memory and Health
BioE Professor Ning Wang published research in Cell Reports that demonstrates a process of mechanomemory within a cell’s nucleus. This discovery prompts a prolonged period of activation of a protein complex responsible for gene expression, which can lead to making new proteins and potentially healthier cells.
Patented Molecule That Eliminates Cancer Cells Commercialized
A patented anticancer molecule, invented by Ning Wang, BioE professor and director of the Institute for Mechanobiology, and three collaborators, is being replicated and commercialized as a research product by several companies, marking a significant advancement that validates the invention.