ChE PhD Dissertation Defense: Ian Smith
Development of an in vitro-in vivo correlation between lymph-cannulated animals and the primary transport assay developed herein might assist preclinical programs in translating lipid-based oral modalities to humans. Expansion of the organoid donor set (by species and small intestinal region), combinatorial probing of more lipid stimulation axes (by substrate chain length and saturation), and scaling of monolayer culture could refine the lymphatic assay into a high-throughput screen.