Mansoor Amiji
University Distinguished Professor,
Pharmaceutical Sciences
University Distinguished Professor,
Chemical Engineering
Affiliated Faculty,
Bioengineering
Center Member,
Cross-College Magnetics Center
Contact
- m.amiji@northeastern.edu
- 360 Huntington Avenue
Boston, MA 02115
Office
- 140 The Fenway, Room 165
- 617.373.3137
Research Focus
Polymeric biomaterials, drug delivery systems, nanomedical technologies
Education
- BS, Pharmacy (magna cum laude), Northeastern University
- PhD, Pharmaceutics, Purdue University
Honors & Awards
- T. Nagai Award, Controlled Release Society
- Fellow, American Association for the Advancement of Science (AAAS)
- Fellow, America Association of Pharmaceutical Scientists (AAPS)
- Fellow, American Institute for Medical and Biological Engineers (AIMBE)
- Fellow, Controlled Release Society
- Charivate Analytics Highly Cited Author (top 1%)
- Distinguished Alumni Award, Purdue University College of Pharmacy
Professional Affiliations
- American Association of Pharmaceutical Scientists, Fellow
- Controlled Release Society, Fellow
Research Overview
Polymeric biomaterials, drug delivery systems, nanomedical technologies
Translational Therapeutic Delivery Laboratory
Success in pharmaceutical and biotechnology product development requires safe and efficient delivery of the therapeutic agent to its target site, which may be quite remote from the administration site. Currently, there are two main challenges in drug delivery: (1) hard-to-deliver molecules and (2) hard-to-reach target sites in the body.
At Northeastern University, we explore customized, innovative solutions to deliver therapeutic and vaccine payloads to their target sites (e.g., brain). Challenging biological molecules such as proteins, peptides, and nucleic acids require efficient delivery modalities to enable their therapeutic functions.
Our approach focuses on multidisciplinary expertise in science and engineering and active collaborations with medical professionals and industrial scientists toward successful product development that can benefit patients.
Selected Research Projects
- Combination Strategy for the Treatment of Advanced Pancreatic Cancer
- – Principal Investigator, National Institutes of Health
- Development and Validation of a Novel Cas13a and Nanoparticle Guide-RNA Delivery System that Allows Precise Ablation of Host Macrophage Populations in a Humanized Mouse Model
- – Principal Investigator, Jackson Laboratories on a National Institutes of Health
- Direct CNS Delivery System for BDNF AntagoNATs using Heterotopic Mucosal Grafting for the Treatment of Parkinson’s Disease
- – Principal Investigator, National Institutes of Health
Department Research Areas
Selected Publications
- Bitounis, D., Amiji, M.M. Lipid nanoparticles target haematopoietic stem cells. Nat. Nanotechnol. (2024). https://doi.org/10.1038/s41565-024-01682-6
- J. Bae, N. Parayath, W. Ma, M. Amiji, N. Munshi, K. Anderson, Bcma Peptide Engineered Nanoparticles Enhance Induction and Function of Antigen Specific Cd8+ Cytotoxic T Lymphocytes Against Multiple Myeloma, Nature – Leukemia, 34, 2020, 210–223
- N.N. Parayath, S. Padmakumar, M. Amiji, Extracellular Vesicle-Mediated Nucleic Acid Transfer and Reprogramming in the Tumor Microenvironment, Cancer Letters, 482(10), 2020, 33-43
- G. Ahmad, G. Mackenzie, J. Egan, M. Amiji, Dha-Sbt-1214 Taxoid Nanoemulsion and Anti-Pd-L1 Antibody Combination Therapy Enhances Antitumor Efficacy in a Syngeneic Pancreatic Adenocarcinoma Model, Molecular Cancer Therapeutics, 18(11), 2019, 961-1972
- D. Chen, N. Parayath, S. Ganesh, W. Wang, M. Amiji, Role of Apolipoprotein-and Vitronectin-Enriched Protein Corona on Lipid Nanoparticles for in Vivo Targeted Delivery and Transfection of Oligonucleotides in Murine Tumor Models, Nanoscale, 11, 2019, 18806–18824
Sep 23, 2025
2025 Stanford University Annual Assessment of Author Citations
The following COE professors are among the top scientists worldwide selected by Stanford University representing the top 2% of the most-cited scientists with single-year impact in various disciplines. The selection is based on the top 100,000 by c-score (with and without self-citations) or a percentile rank of 2% or above.
Aug 11, 2025
The Future of mRNA Vaccines
Bouvé/ChE University Distinguished Professor Mansoor Amiji, discusses the future of creating mRNA vaccines and the technology behind developing these vaccines.
Jun 25, 2025
GLP-1 Weight Loss Drug Prices Are Unlikely To Decrease in the Near Future
Bouvé/ChE University Distinguished Professor Mansoor Amiji says people seeking weight loss drugs may be able to get help from patient financial assistance programs and alternative medications. Mounjaro weight loss drug’s active ingredient—semaglutide—is no longer in short supply, so less expensive GLP-1 compounded versions are no longer available.
Mar 27, 2025
Amiji Elected AAAS Fellow
Bouvé/ChE University Distinguished Professor Mansoor Amiji was elected as an American Association for the Advancement of Science (AAAS) 2024 Fellow in the Pharmaceutical Sciences section for distinguished contributions in pharmaceutical sciences with a specific focus on targeted drug delivery for a variety of diseases including cancer, inflammatory diseases, and CNS diseases.
Jan 31, 2025
Bypassing Blood-Brain Barrier for Targeted Brain Therapy
Bouvé/ChE University Distinguished Professor Mansoor Amiji’s research on the “Effective Nose-to-Brain Delivery of Blood-Brain Barrier Impermeant Anti-IL-1β Antibody via the Minimally Invasive Nasal Depot (MIND) Technique” was published in ACS Applied Materials & Interfaces.
Jan 31, 2025
Improving Drug Delivery to the Brain
Bouvé/ChE University Distinguished Professor Mansoor Amiji’s research on the “Murine Model of Minimally Invasive Nasal Depot (MIND) Technique for Central Nervous System Delivery of Blood–Brain Barrier-Impermeant Therapeutics” was published in Lab Animal.
Jan 31, 2025
2024 Stanford University Annual Assessment of Author Citations
The following COE professors are among the top scientists worldwide selected by Stanford University representing the top 2% of the most-cited scientists with single-year impact in various disciplines. The selection is based on the top 100,000 by c-score (with and without self-citations) or a percentile rank of 2% or above. The list below includes those who published a paper in 2024 or later.
Jan 31, 2025
Treating Lung Diseases Using Nanotechnology
Bouvé/ChE University Distinguished Professor Mansoor Amiji’s research on the “Interplay of Nano-based Delivery Systems and Protein Signalling in Ameliorating Lung Diseases” was published in Journal of Drug Delivery Science and Technology.
Jan 31, 2025
Improving Vaccine Adjuvant Production Methods
Bouvé/ChE University Distinguished Professor Mansoor Amiji’s research on “Microfluidic-Chip-Based Formulation and In Vivo Evaluations of Squalene Oil Emulsion Adjuvants for Subunit Vaccines” was published in Vaccines.
Jan 09, 2025
Patent for Combining Drugs and Immunotherapy for Cancer Treatment
Bouvé/ChE University Distinguished Professor Mansoor Amiji was awarded a patent for “Combination taxoid nanoemulsion with immunotherapy in cancer.”