Srirupa Chakraborty
Assistant Professor, Chemical Engineering
Assistant Professor, Chemistry and Chemical Biology
Affiliated Faculty, Physics
Office
- 224 Cullinane
- (617) 373-8258
Lab
- 001 Mugar
- (617) 373-3749
Related Links
Research Focus
Theoretical biology and biophysics; Computational modeling and simulations; Structure-dynamics of complex bio-systems; Rational design of glycoprotein-based therapeutic strategies
About
Srirupa Chakraborty obtained a PhD in Biophysics from the State University of New York at Buffalo in 2016, prior to which she had earned a B.S. in Physics from Presidency College, University of Calcutta, followed by M.S. in Physics from the Indian Institute of Technology – Guwahati (India). After a brief stint as a visiting scientist at IBM Watson Research Center where her research on cognitive learning platform design led to two patents, she has been a postdoctoral researcher at Los Alamos National Laboratory. There, her work developing novel tools and techniques to bridge in silico results and experimental data through theoretical modeling was recognized with the Wiley Computers in Chemistry Outstanding Research Award by the American Chemical Society in 2020, and an award by the Consortia for HIV/AIDS Vaccine Development (CHAVD) in 2019. Her research focus is in the interface of biology, chemistry and physics, where she uses computer-aided structural modeling and simulations of biomolecules. Her current research aims to elucidate the conformational dynamics of viral envelope glycoproteins and other densely glycosylated systems, ultimately designing knowledge-based therapeutic strategies and novel biomaterials.
Honors & Awards
- 2023 National Institutes of Health Maximizing Investigator’s Research Award (MIRA) for Early Stage Investigators
Research Overview
Theoretical biology and biophysics; Computational modeling and simulations; Structure-dynamics of complex bio-systems; Rational design of glycoprotein-based therapeutic strategies
SimBioSys Lab
The SimBioSys Lab focuses on structure-dynamics modeling of complex biosystems by looking at these through the virtual microscope. The goal of the lab is to solve biomedical problems at the molecular level both from first principles, as well as harnessing data-driven approaches. Our research is at the interface of biochemistry, physics, chemical engineering and computer science where we strive to bridge theoretical modeling, in silico results, and experimental data.
Selected Research Projects
- Modeling the mucosal glycopeptide mesh for improved disease understanding and mucin-inspired biomaterial design
- – Principal Investigator, NIH
Department Research Areas
Jan 11, 2024
Announcing Spring 2024 PEAK Experiences Student Awardees
A record number of engineering students and science students mentored by COE faculty are recipients of Northeastern’s Spring 2024 PEAK Experiences Awards.
Jan 11, 2024
Announcing Spring 2024 AJC Merit Research Scholars
Several engineering students and students mentored by COE faculty are recipients of the Spring 2024 AJC Merit Research Scholars, which funds a co-op in the laboratory of a Northeastern University STEM faculty member.
Dec 18, 2023
Using Computer Modeling to Treat Cystic Fibrosis
ChE/COS Assistant Professor Srirupa Chakraborty’s lab uses high-powered computing to develop proteins with a range of possible uses, from water purification to more effective drug treatments for a range of stubborn diseases.
Oct 20, 2023
Developing a Computer Model for Improved Disease Understanding
ChE Assistant Professor Srirupa Chakraborty was awarded a $1.99 million NIH R35 MIRA award for “Modeling the mucosal glycopeptide mesh for improved disease understanding and mucin-inspired biomaterial design.”
Oct 20, 2023
Developing a Computer Model to Deliver Gene Therapies for Cystic Fibrosis
ChE Assistant Professor Srirupa Chakraborty was awarded a $100K NIH SBIR award for “Computationally-Inspired Design of Non-Viral Gene Delivery Vehicles for mRNA-Based Cystic Fibrosis Therapies.”
Apr 27, 2023
Announcing Summer 2023 PEAK Experiences Awardees
Several engineering students and science students mentored by COE faculty are recipients of Northeastern’s Summer 2023 PEAK Experiences Awards. They will be pursuing a diverse set of projects, including a study of a pathogen that haunts hospitals, an examination of segregationist rhetoric in Boston newspapers, and an analysis of creativity in music.
Jan 03, 2022
New Faculty Spotlight: Srirupa Chakraborty
Srirupa Chakraborty joins the Chemical Engineering department in January 2022 as an Assistant Professor with a joint appointment in Chemistry and Chemical Biology.