Eno E. Ebong

Associate Professor and Associate Chair for Graduate Studies,  Chemical Engineering
Associate Professor,  Bioengineering
Affiliated Faculty,  Biology

Contact

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Office

  • 221 ISEC
  • 617.373.8744

Lab

  • 275C ISEC
  • 617.373.7238

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Research Focus

Studying the means by which endothelial cell mechanotransduction occurs in order to prevent or promote diseases related to blood vessel dysfunction

About

Joined Northeastern University in Fall 2013.

Directs the “Ebong Mechanobiology Laboratory”, where research currently focuses on studying how the mechanical forces of blood flow and tissue stiffness affect endothelial cells, which line the blood vessels and guard them from dysfunction that leads to diseases like atherosclerosis, cancer metastasis, and neurodegeneration. Much of the research focus is on studying the structure and function of the protective gel-like layer of sugar molecules and proteins coating the surface of the endothelial cells—called the glycocalyx—to understand, on a molecular level, how mechanobiology remodels the endothelial cells to facilitate protection from disease. This glycocalyx structure gives endothelial cells the resilience they need to withstand the raucous mechanical environment that they are subjected to, especially due to dynamic blood flows at the vessel branch points. Glycocalyx sheds in the presence of disease, so it is of great interest to study how gradual glycocalyx degradation initiates and promotes pathology. The “Ebong Mechanobiology Laboratory” constructs in vitro fluid-solid systems comprised of endothelial cells co-cultured with support cells, to replicate both healthy and disruptive conditions and to uncover the intricacies of the mechanics-glycocalyx-endothelial cell relationship. This work is combined with live animal studies to assess the validity of the findings, in real disease conditions. Other approaches include biomaterials, state-of-the-art electron microscopy (mainly rapid freezing/freeze substitution preservation and transmission electron microscopy), advanced biological imaging of cells and animals, RNA interference techniques, fluorescent intracellular biomarkers, protein biochemistry, and more. Our discoveries are being applied to the development of therapies and nanomedicine-based drug delivery tools that target mechanobiology, endothelial cells, and the glycocalyx to prevent and/or reverse disease.

Education

  • B.S. (Mechanical Engineering) Massachusetts Institute of Technology, 1999
  • M.Eng. (Biomedical Engineering) Rensselaer Polytechnic Institute, 2001
  • Ph.D. (Biomedical Engineering) Rensselaer Polytechnic Institute, 2006
  • Postdoctoral Fellowship Albert Einstein College of Medicine and CUNY City College of New York, 2007-2012

Honors & Awards

  • 2020 Frontiers of Engineering Symposium Invited Attendee, NAE
  • NIH Mentored Research Scientist Career Development Award
  • NSF Faculty Early Career Development Program (CAREER) Award
  • Gordon Research Conference Carl Storm Underrepresented Minority Fellow
  • Northeastern University College of Engineering Faculty Fellow

Research Overview

Studying the means by which endothelial cell mechanotransduction occurs in order to prevent or promote diseases related to blood vessel dysfunction

Ebong Laboratory

Professor Ebong’s research focuses on studying the effects of the mechan­ical forces of blood flow on the endothe­lial cells that line and pro­tect our blood vessels—work that is aimed at advancing vas­cular dis­ease treatment.

Ebong Lab

Selected Research Projects

Selected Publications

  • Mensah, S.A., Nersesyan, A., Harding, I.C., Lee, C.I., Tan, X., Banerjee, S., Niedre, M.J.,Torchilin, V.P., and Ebong E.E. Flow-Regulated Endothelial Glycocalyx Determines Metastatic Cancer Cell Activity. FASEB J. 2020 May; 34(5): 6166-6184.
  • Cheng, M.J., Mitra, R., Okorafor, C.C., Nersesyan, A.A., Harding, I.C., Bal, N.N., Kumar R., Sridhar S., and Ebong E.E. Targeted Intravenous Nanoparticle Delivery: Role of Flow and Endothelial Glycocalyx Integrity. Ann Biomed Eng. 2020 Jul; 48(7): 1941-1954.
  • Cai, X., Qiao, J., Kulkarni, P., Harding, I.C., Ebong, E., and Ferris, C.F. Imaging the effect of the circadian light-dark cycle on the glymphatic system in awake rats. Proc Natl Acad Sci U S A. 2020 Jan; 117 (1): 668-676.
  • Mensah, S.A., Harding, I., Zhang, M., Lee, C., Torchilin, V., Niedre, M., and Ebong E.E. Metastatic cancer cell attachment to endothelium is promoted by endothelial glycocalyx sialic acid degradation. AIChE Journal. 2019 May; 65(8): e16634.
  • Harding, I.C., Mitra, R., Mensah, S.A., Nersesyan, A., Bal, N.N., and Ebong, E.E. Endothelial Barrier Reinforcement Relies on Flow-Regulated Glycocalyx, a Potential Therapeutic Target. Biorheology. 2019 March; 56(2-3): 131-149.

Students

Jun 07, 2021

Summer 2021 PEAK Experiences Awardees

Congratulations to the COE student recipients of the Summer 2021 PEAK Experiences Awards. The PEAK Experiences Awards are a progressively structured sequence of opportunities designed to support learners as they continue climbing to new heights of achievement in undergraduate research and creative endeavor throughout their Northeastern journeys. BASE CAMP AWARDS Ana Salichs, COE’22, “Colorimetric Assays […]

photo of solomon mensah and eno ebong

Alumni

May 04, 2021

It Started with a Mentor

After earning his bachelor’s degree at City College of New York, Solomon Mensah, PhD’19, bioengineering, chose to further his education at Northeastern for its entrepreneurial atmosphere, and to study under his undergraduate mentor who joined Northeastern, Associate Professor Eno Ebong, chemical engineering and bioengineering. Mensah’s graduate research, supervised by Ebong, examined inter-cellular interactions in cancer […]

In the Media

Feb 01, 2021

1,000 inspiring Black scientists in America

ChE Assistant Professor Andrew Jones, Professor Debra Auguste, Assistant Professor Eno Ebong, and Solomon Mensah (former PhD student of Eno Ebong) were featured in Cell Mentor’s article of “1,000 inspiring Black scientists in America.”

Faculty

Nov 12, 2020

ChE and BioE Professor Eno Ebong Presents Invited Talk at American Society for Investigative Pathology Symposium

ChE and BioE Associate Professor Eno Ebong presented an invited talk entitled “Glycocalyx-Mediated Vascular Remodeling and Permeability in Disturbed Flow” at PISA (Pathobiology for Investigators, Students, & Academicians) 2020, an American Society for Investigative Pathology symposium.

Faculty

Sep 10, 2020

Faculty and Staff Awards 2020

Congratulations to all the winners of the faculty and staff awards, and to everyone for their hard work and dedication during the 2019-2020 academic school year.

Eno Ebong

Faculty

Jun 23, 2020

Ebong Selected to Attend US Frontiers of Engineering Symposium

ChE/BioE Associate Professor Eno Ebong was invited to represent Northeastern at the National Academy of Engineering’s US Frontiers of Engineering Symposium, February 25-26, 2021. Ebong was among eighty-five of the nation’s brightest early-career engineers selected to take part in the National Academy of Engineering’s (NAE) 26th annual US Frontiers of Engineering (USFOE) symposium. The symposium covers […]

Faculty

Jan 30, 2020

Translating the ‘Mastermind’ Concept from Business to Academia

Assistant Professors Danielle Levac (Bouvé), Emily Zimmerman (Bouvé), Kristen Allison (Bouvé), Abigail Koppes (ChE), Sarah Ostadabbas (ECE), Jessica Oakes (BioE), and Associate Professor Eno Ebong (ChE) were awarded a 2020 ADVANCE Mutual Mentoring Advancement Program (M2AP) Grant for “Translating the ‘Mastermind’ Concept from Business to Academia: Facilitating Peer mentorship among female PIs leading active research labs”.

Jan 27, 2020

Spring 2020 PEAK Experiences Awardees

Congratulations to the COE student recipients of the Spring 2020 PEAK Experiences Awards. The PEAK Experiences Awards are a progressively structured sequence of opportunities designed to support learners as they continue climbing to new heights of achievement in undergraduate research and creative endeavor throughout their Northeastern journeys. BASE CAMP AWARDS Developing HPLC Methods for Characterizing […]

Faculty

Feb 13, 2019

Ebong Receives NSF CAREER Award

ChE Assistant Professor Eno Ebong received an NSF CAREER award for “EMBRACE STEM (Endothelial MechanoBiology Research And multiCultural Education in STEM).”

Faculty

Dec 19, 2018

Ebong Lab Accomplishments

This semester has been a great one for Chemical Engineering Professor Eno Ebong's Lab.  They have had three accepted papers in the Translational Medicine Communications, International Journal of Nanomedicine, and Journal of Translational Medicine. While the other two are still in press, be sure to take a chance to read "The comparative effects of high fat diet or […]

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