Eno E. Ebong

Associate Professor and Associate Chair for Graduate Studies,  Chemical Engineering
Associate Professor,  Bioengineering
Affiliated Faculty,  Biology

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Office

  • 221 ISEC
  • 617.373.8744

Lab

  • 275C ISEC
  • 617.373.7238

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Research Focus

Studying the means by which endothelial cell mechanotransduction occurs in order to prevent or promote diseases related to blood vessel dysfunction

About

Joined Northeastern University in Fall 2013.

Directs the “Ebong Mechanobiology Laboratory”, where research currently focuses on studying how the mechanical forces of blood flow and tissue stiffness affect endothelial cells, which line the blood vessels and guard them from dysfunction that leads to diseases like atherosclerosis, cancer metastasis, and neurodegeneration. Much of the research focus is on studying the structure and function of the protective gel-like layer of sugar molecules and proteins coating the surface of the endothelial cells—called the glycocalyx—to understand, on a molecular level, how mechanobiology remodels the endothelial cells to facilitate protection from disease. This glycocalyx structure gives endothelial cells the resilience they need to withstand the raucous mechanical environment that they are subjected to, especially due to dynamic blood flows at the vessel branch points. Glycocalyx sheds in the presence of disease, so it is of great interest to study how gradual glycocalyx degradation initiates and promotes pathology. The “Ebong Mechanobiology Laboratory” constructs in vitro fluid-solid systems comprised of endothelial cells co-cultured with support cells, to replicate both healthy and disruptive conditions and to uncover the intricacies of the mechanics-glycocalyx-endothelial cell relationship. This work is combined with live animal studies to assess the validity of the findings, in real disease conditions. Other approaches include biomaterials, state-of-the-art electron microscopy (mainly rapid freezing/freeze substitution preservation and transmission electron microscopy), advanced biological imaging of cells and animals, RNA interference techniques, fluorescent intracellular biomarkers, protein biochemistry, and more. Our discoveries are being applied to the development of therapies and nanomedicine-based drug delivery tools that target mechanobiology, endothelial cells, and the glycocalyx to prevent and/or reverse disease.

Education

  • B.S. (Mechanical Engineering) Massachusetts Institute of Technology, 1999
  • M.Eng. (Biomedical Engineering) Rensselaer Polytechnic Institute, 2001
  • Ph.D. (Biomedical Engineering) Rensselaer Polytechnic Institute, 2006
  • Postdoctoral Fellowship Albert Einstein College of Medicine and CUNY City College of New York, 2007-2012

Honors & Awards

  • NIH Mentored Research Scientist Career Development Award
  • NSF Faculty Early Career Development Program (CAREER) Award
  • Gordon Research Conference Carl Storm Underrepresented Minority Fellow
  • Northeastern University College of Engineering Faculty Fellow

Research Overview

Studying the means by which endothelial cell mechanotransduction occurs in order to prevent or promote diseases related to blood vessel dysfunction

Selected Research Projects

  • Atheroprotective vs Atherogenic Glycocalyx Mechanotransduction Mechanisms
    • Principal Investigator, National Institutes of Health
  • EMBRACE STEM (Endothelial MechanoBiology Research and multiCultural Education in STEM)
    • Principal Investigator, National Science Foundation

Department Research Areas

Selected Publications

  • Mensah, S.A., Nersesyan, A., Harding, I.C., Lee, C.I., Tan, X., Banerjee, S., Niedre, M.J.,Torchilin, V.P., and Ebong E.E. Flow-Regulated Endothelial Glycocalyx Determines Metastatic Cancer Cell Activity. FASEB J. 2020 May; 34(5): 6166-6184.
  • Cheng, M.J., Mitra, R., Okorafor, C.C., Nersesyan, A.A., Harding, I.C., Bal, N.N., Kumar R., Sridhar S., and Ebong E.E. Targeted Intravenous Nanoparticle Delivery: Role of Flow and Endothelial Glycocalyx Integrity. Ann Biomed Eng. 2020 Jul; 48(7): 1941-1954.
  • Cai, X., Qiao, J., Kulkarni, P., Harding, I.C., Ebong, E., and Ferris, C.F. Imaging the effect of the circadian light-dark cycle on the glymphatic system in awake rats. Proc Natl Acad Sci U S A. 2020 Jan; 117 (1): 668-676.
  • Mensah, S.A., Harding, I., Zhang, M., Lee, C., Torchilin, V., Niedre, M., and Ebong E.E. Metastatic cancer cell attachment to endothelium is promoted by endothelial glycocalyx sialic acid degradation. AIChE Journal. 2019 May; 65(8): e16634.
  • Harding, I.C., Mitra, R., Mensah, S.A., Nersesyan, A., Bal, N.N., and Ebong, E.E. Endothelial Barrier Reinforcement Relies on Flow-Regulated Glycocalyx, a Potential Therapeutic Target. Biorheology. 2019 March; 56(2-3): 131-149.

Faculty

Nov 12, 2020

ChE and BioE Professor Eno Ebong Presents Invited Talk at American Society for Investigative Pathology Symposium

ChE and BioE Associate Professor Eno Ebong presented an invited talk entitled “Glycocalyx-Mediated Vascular Remodeling and Permeability in Disturbed Flow” at PISA (Pathobiology for Investigators, Students, & Academicians) 2020, an American Society for Investigative Pathology symposium.

Faculty

Sep 10, 2020

Faculty and Staff Awards 2020

Congratulations to all the winners of the faculty and staff awards, and to everyone for their hard work and dedication during the 2019-2020 academic school year.

Faculty

Jan 30, 2020

Translating the ‘Mastermind’ Concept from Business to Academia

Assistant Professors Danielle Levac (Bouvé), Emily Zimmerman (Bouvé), Kristen Allison (Bouvé), Abigail Koppes (ChE), Sarah Ostadabbas (ECE), Jessica Oakes (BioE), and Associate Professor Eno Ebong (ChE) were awarded a 2020 ADVANCE Mutual Mentoring Advancement Program (M2AP) Grant for “Translating the ‘Mastermind’ Concept from Business to Academia: Facilitating Peer mentorship among female PIs leading active research labs”.

Faculty

Feb 13, 2019

Ebong Receives NSF CAREER Award

ChE Assistant Professor Eno Ebong received an NSF CAREER award for “EMBRACE STEM (Endothelial MechanoBiology Research And multiCultural Education in STEM).”

Faculty

Dec 19, 2018

Ebong Lab Accomplishments

This semester has been a great one for Chemical Engineering Professor Eno Ebong's Lab.  They have had three accepted papers in the Translational Medicine Communications, International Journal of Nanomedicine, and Journal of Translational Medicine. While the other two are still in press, be sure to take a chance to read "The comparative effects of high fat diet or […]

Students

Mar 26, 2018

PhD Student Selected to Speak at Global Health & Innovation Conference

BioE PhD student Solomon Mensah and CEO of Therapeutic Innovation was selected through a competitive process to present his Social Impact Pitch on “Re-Examining the Design of the Neonatal Bubble-CPAP for Application in the Developing World” at the 15th annual Global Health & Innovation Conference.

Faculty

Jul 24, 2017

Northeastern Researchers Contribute to Methodist DeBakey Cardiovascular Journal

The Methodist DeBakey Cardiovascular Journal (MDCVJ) reports on leading edge research, diagnosis, and treatments from specialists at the Houston Methodist DeBakey Heart & Vascular Center and other invited contributors. In Volume 12, Number 3 (July-September 2016), numerous faculty and one PhD student had their research featured in the journal. Nucleic Acid Delivery for Endothelial Dysfunction in […]

Sep 19, 2016

Eno Ebong, Abby Koppes, & Ryan Koppes to Participate in Tufts CTSI Junior Faculty Career Development Forum

Eno Ebong, Prof. Abby Koppes, and Prof. Ryan Koppes were selected as three out of the 29 junior faculty members chosen to participate in the Tufts CTSI 2016-2017 Junior Faculty Research Career Development Forum.

Graduate

Apr 04, 2016

BioE PhD Student Solomon Mensah Receives 2016 NSF Graduate Research Fellowship Award

Solomon Mensah is a Doctoral student in the Department of Bioengineering and a 2016 recipient of the prestigious National Science Foundation Graduate Research Fellowship Award. He will use his award to investigate inter-cellular interactions in cancer and cardiovascular diseases, and to study the role played by the blood vessel wall sugar coating called “glycocalyx."  Mensah's work, is supervised by Professor […]

Mar 22, 2016

FY17 TIER 1 Award Recipients

23 COE faculty and affiliates were recipients of FY17 TIER 1 Interdisciplinary Research Seed Grants for 12 different projects representing over $600K dollars of investment in research.

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