Ryan Koppes

About

Joined the Chemical Engineering Department in Fall 2015.

Selected Publications

• Bindas, Adam J., Kulkarni, Subhash, Koppes, Ryan A., Koppes, Abigail N. (2021). Parkinson’s Disease and the Gut: Models of an Emerging Relationship. Acta Biomaterialia, . 10.1016/J.ACTBIO.2021.03.071
• Diaz Vera, David, Soucy, Jonathan R., Lee, Audrey, Koppes, Ryan A., Koppes, Abigail N. (2021). Light irradiation of peripheral nerve cells: Wavelength impacts primary sensory neuron outgrowth in vitro. Journal of Photochemistry and Photobiology B: Biology, 215,112105. 10.1016/J.JPHOTOBIOL.2020.112105
• Ventre, Daniel M., Cluff, Avery, Gagnon, Christian, Diaz Vera, David, Koppes, Ryan A., Koppes, Abigail N. (2021). The effects of low intensity focused ultrasonic stimulation on dorsal root ganglion neurons and Schwann cells in vitro. Journal of Neuroscience Research, 99(1),374-391. 10.1002/JNR.24700
• S. Hosic, W. Lake, E. Stas, R.A. Koppes, D.T. Breault, S.K. Murthy, A.N. Koppes, Cholinergic Activation of Primary Human Derived Intestinal Epithelium does not Ameliorate TNF-𝛼 Induced Injury, Cellular and Molecular Bioengineering, 2020
• T. Torregrosa, S. Webster, C. Aghaizu, J. Soucy, C. Bertucci, L. Plant, A.N. Koppes, R.A. Koppes Cryopreservation and Functional Analysis of Cardiac Autonomic Neurons, Journal of Neuroscience Methods, 341, 2020, 108724
• J. Snyder, C. Wang, A.Q. Zhang, Y. Li, J. Luchan, S. Hosic, R. Koppes, R.L. Carrier, A. Koppes, Materials and Microenvironments for Engineering the Intestinal Epithelium, Annals of Biomedical Engineering, 48, 2020, 1916–1940
• S. Hosic, A. Bindas, M. Puzan, W. Lake, J. Soucy, F. Zhou, R.A. Koppes, D. Breault, S. Murthy, A.N. Koppes Rapid Prototyping of Multilayer Micro Physiological Systems, ACS Biomaterials Science & Engineering, 2020
• K. Nichols, R. Koppes, A. Koppes, Recent Advancements in Micro Physiological Systems for Neural Development and Disease, Current Opinion in Biomedical Engineering, 14, 2020, 42-51
• A.R. Spencer, E.S. Sani, J.R. Soucy, C.C. Corbet, A. Primebetova, R.A. Koppes, N. Annabi Bioprinting of a Cell-Laden Conductive Hydrogel Composite, ACS Applied Material Interfaces, 11(34), 2019, 30518-30533
• J.R. Soucy, A.J. Bindas, A.N. Koppes, R.A. Koppes Instrumented Micro Physiological Systems for Real- Time Measurement and Manipulation of Cellular Electrochemical Processes, iScience, 21, 2019, 521-548

Faculty

Oct 12, 2021

Koppes Awarded $1.96M Early-Stage Investigator Grant from NIH

ChE Assistant Professor Ryan Koppes received a $1.96M NIH R35 MIRA (Maximizing Investigator’s Research Award) for Early Stage Investigators for “Engineering Multifaceted 3D Human Organ Platforms for Toxicity Testing.” This research will help to develop human organs-on-a-chip to improve drug toxicity testing.

Faculty

May 20, 2021

Improving Vein Grafts for Patients with Cardiovascular Diseases

BioE Associate Professor Guohao Dai (PI), ChE Assistant Professors Ryan Koppes (PI), and Abigail Koppes (co-PI) were awarded a $430K NIH grant from the National Institute of Neurological Disorders and Stroke for “Bioengineer a Humanized Autonomic Neurovascular Innervation on a Chip”.

Spotlight Story

Oct 02, 2020

PhD Spotlight: Jonathan Soucy, PhD’20 – Chemical Engineering

Advised by Assistant Professor Ryan Koppes, Chemical Engineering After receiving his bachelor’s degree in chemical engineering from Rensselaer Polytechnic Institute in 2015, Jonathan Soucy joined Northeastern University pursuing a PhD in chemical engineering. His research has focused on neurochemistry, specifically on the sympathetic and parasympathetic nerve systems—the mechanisms by which the brain controls the speed […]

Faculty

Sep 03, 2020

Abigail and Ryan Koppes Featured on Inside Front Cover of Advanced Biosystems

ChE Assistant Professors Abigail Koppes and Ryan Koppes’ research on “Reconfigurable Microphysiological Systems for Modeling Innervation and Multitissue Interactions” was published in the September issue of Advanced Biosystems.

Faculty

Sep 03, 2020

Fang and Koppes Receive $2.2M NIH Award Leading to State-of-the-Art Electrophysiological Capabilities

ECE Assistant Professor Hui Fang (PI) and ChE Assistant Professor Ryan Koppes (co-PI), in collaboration with UCLA and Boston Children’s Hospital, received a $2.2M NIH grant for “Novel transparent, ultra-soft neuroelectrode arrays based on nanomeshing conventional electrode materials.” In this study, they propose to prove a novel electrode concept, nanomeshing conventional electrode materials, can lead to state-of-the-art electrophysiological capabilities while allowing at the same time, optical and chronic-bio- compatibilities. Besides enabling new hypothesis-driven neuroscience studies from overcoming major barriers of integrating in-vivo electrical recordings with optical approaches, the proposed research will also provide unique opportunities for next-generation therapeutic interventions via sustainable neural prosthetics.

Faculty

Aug 13, 2020

Abigail Koppes and Ryan Koppes Published in the Journal of Neuroscience Research

ChE Assistant Professors Abigail Koppes and Ryan Koppes published their research in the Journal of Neuroscience titled: “The effects of low intensity focused ultrasonic stimulation on dorsal root ganglion neurons and Schwann cells in vitro.”

Faculty

Jul 16, 2020

Cryopreservation of Cardiac Autonomic Neurons

ChE Assistant Professor Abigail Koppes and Assistant Professor Ryan Koppes’ research on “Cryopreservation and functional analysis of cardiac autonomic neurons” was published in the Journal of Neuroscience Methods.

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