Ryan Koppes
Assistant Professor, Chemical Engineering
Office
- 339 Mugar
- 617.373.8547
Lab
- 111 Mugar
- 617.373.8161
Related Links
Research Focus
neural interface technology, tissue engineering, and musculoskeletal biomechanics
About
Joined the Chemical Engineering Department in Fall 2015.
Education
- PhD (2013) Rensselaer Polytechnic Institute, Biomedical Engineering
- MS (2010) Rensselaer Polytechnic Institute, Biomedical Engineering, area of concentration: Muscle Tissue Engineering
- BS (2008) Rensselaer Polytechnic Institute, Biomedical Engineering, area of concentration: Biomaterials
Honors & Awards
- NIH National Institute of Biomedical Imaging and Bioengineering Trailblazer Award for New and Early Stage Investigators
- Gilda Barbino Excellence in Mentoring Award
Professional Affiliations
- American Society for Mechanical Engineers
- Biophysical Society
- Biomedical Engineering Society
- Materials Research Society
Research Overview
neural interface technology, tissue engineering, and musculoskeletal biomechanics
Laboratory for Neuromodulation and Neuromuscular Repair
We study the physical bridge between cells and electronics to improve nerve gap and prosthetic technologies. We’re also interested in neuron interactions with the heart to help relieve the healthcare burden of heart failure. Located in Boston, our group is able to join with other top universities to collaborate on ground breaking research.
Selected Research Projects
- Novel Transparent, Ultra-soft Neuroelectrode Arrays Based on Nanomeshing Conventional Electrode Materials
- – Co-Principal Investigator, NIH
- Bioengineer Autonomic Neurovascular System to Explore the Innervation of Vascular Grafts
- – Principal Investigator, American Heart Association
- Engineering A Humanized Gut-Enteric-Axis
- – Principal Investigator, National Institutes of Health
Department Research Areas
Selected Publications
- Bindas, Adam J., Kulkarni, Subhash, Koppes, Ryan A., Koppes, Abigail N. (2021). Parkinson’s Disease and the Gut: Models of an Emerging Relationship. Acta Biomaterialia, . 10.1016/J.ACTBIO.2021.03.071
- Diaz Vera, David, Soucy, Jonathan R., Lee, Audrey, Koppes, Ryan A., Koppes, Abigail N. (2021). Light irradiation of peripheral nerve cells: Wavelength impacts primary sensory neuron outgrowth in vitro. Journal of Photochemistry and Photobiology B: Biology, 215,112105. 10.1016/J.JPHOTOBIOL.2020.112105
- Ventre, Daniel M., Cluff, Avery, Gagnon, Christian, Diaz Vera, David, Koppes, Ryan A., Koppes, Abigail N. (2021). The effects of low intensity focused ultrasonic stimulation on dorsal root ganglion neurons and Schwann cells in vitro. Journal of Neuroscience Research, 99(1),374-391. 10.1002/JNR.24700
- S. Hosic, W. Lake, E. Stas, R.A. Koppes, D.T. Breault, S.K. Murthy, A.N. Koppes, Cholinergic Activation of Primary Human Derived Intestinal Epithelium does not Ameliorate TNF-𝛼 Induced Injury, Cellular and Molecular Bioengineering, 2020
- T. Torregrosa, S. Webster, C. Aghaizu, J. Soucy, C. Bertucci, L. Plant, A.N. Koppes, R.A. Koppes Cryopreservation and Functional Analysis of Cardiac Autonomic Neurons, Journal of Neuroscience Methods, 341, 2020, 108724
- J. Snyder, C. Wang, A.Q. Zhang, Y. Li, J. Luchan, S. Hosic, R. Koppes, R.L. Carrier, A. Koppes, Materials and Microenvironments for Engineering the Intestinal Epithelium, Annals of Biomedical Engineering, 48, 2020, 1916–1940
- S. Hosic, A. Bindas, M. Puzan, W. Lake, J. Soucy, F. Zhou, R.A. Koppes, D. Breault, S. Murthy, A.N. Koppes Rapid Prototyping of Multilayer Micro Physiological Systems, ACS Biomaterials Science & Engineering, 2020
- K. Nichols, R. Koppes, A. Koppes, Recent Advancements in Micro Physiological Systems for Neural Development and Disease, Current Opinion in Biomedical Engineering, 14, 2020, 42-51
- A.R. Spencer, E.S. Sani, J.R. Soucy, C.C. Corbet, A. Primebetova, R.A. Koppes, N. Annabi Bioprinting of a Cell-Laden Conductive Hydrogel Composite, ACS Applied Material Interfaces, 11(34), 2019, 30518-30533
- J.R. Soucy, A.J. Bindas, A.N. Koppes, R.A. Koppes Instrumented Micro Physiological Systems for Real- Time Measurement and Manipulation of Cellular Electrochemical Processes, iScience, 21, 2019, 521-548
Jun 07, 2021
Summer 2021 PEAK Experiences Awardees
Congratulations to the COE student recipients of the Summer 2021 PEAK Experiences Awards. The PEAK Experiences Awards are a progressively structured sequence of opportunities designed to support learners as they continue climbing to new heights of achievement in undergraduate research and creative endeavor throughout their Northeastern journeys. BASE CAMP AWARDS Ana Salichs, COE’22, “Colorimetric Assays […]
May 20, 2021
Improving Vein Grafts for Patients with Cardiovascular Diseases
BioE Associate Professor Guohao Dai (PI), ChE Assistant Professors Ryan Koppes (PI), and Abigail Koppes (co-PI) were awarded a $430K NIH grant from the National Institute of Neurological Disorders and Stroke for “Bioengineer a Humanized Autonomic Neurovascular Innervation on a Chip”.
Oct 02, 2020
PhD Spotlight: Jonathan Soucy, PhD’20 – Chemical Engineering
Advised by Assistant Professor Ryan Koppes, Chemical Engineering After receiving his bachelor’s degree in chemical engineering from Rensselaer Polytechnic Institute in 2015, Jonathan Soucy joined Northeastern University pursuing a PhD in chemical engineering. His research has focused on neurochemistry, specifically on the sympathetic and parasympathetic nerve systems—the mechanisms by which the brain controls the speed […]
Sep 16, 2020
Koppes and Bencherif Published in Bioelectricity
ChE Assistant Professors Ryan Koppes and Sidi A. Bencherif were published in Bioelectricity for their research on “Electroconductive Hydrogels for Tissue Engineering: Current Status and Future Perspectives.”
Sep 03, 2020
Abigail and Ryan Koppes Featured on Inside Front Cover of Advanced Biosystems
ChE Assistant Professors Abigail Koppes and Ryan Koppes’ research on “Reconfigurable Microphysiological Systems for Modeling Innervation and Multitissue Interactions” was published in the September issue of Advanced Biosystems.
Sep 03, 2020
Fang and Koppes Receive $2.2M NIH Award Leading to State-of-the-Art Electrophysiological Capabilities
ECE Assistant Professor Hui Fang (PI) and ChE Assistant Professor Ryan Koppes (co-PI), in collaboration with UCLA and Boston Children’s Hospital, received a $2.2M NIH grant for “Novel transparent, ultra-soft neuroelectrode arrays based on nanomeshing conventional electrode materials.” In this study, they propose to prove a novel electrode concept, nanomeshing conventional electrode materials, can lead to state-of-the-art electrophysiological capabilities while allowing at the same time, optical and chronic-bio- compatibilities. Besides enabling new hypothesis-driven neuroscience studies from overcoming major barriers of integrating in-vivo electrical recordings with optical approaches, the proposed research will also provide unique opportunities for next-generation therapeutic interventions via sustainable neural prosthetics.
Aug 13, 2020
Abigail Koppes and Ryan Koppes Published in the Journal of Neuroscience Research
ChE Assistant Professors Abigail Koppes and Ryan Koppes published their research in the Journal of Neuroscience titled: “The effects of low intensity focused ultrasonic stimulation on dorsal root ganglion neurons and Schwann cells in vitro.”
Jul 16, 2020
Cryopreservation of Cardiac Autonomic Neurons
ChE Assistant Professor Abigail Koppes and Assistant Professor Ryan Koppes’ research on “Cryopreservation and functional analysis of cardiac autonomic neurons” was published in the Journal of Neuroscience Methods.
Jun 24, 2020
Investigating Intestinal Inflammation
ChE Assistant Professor Abigail Koppes and Assistant Professor Ryan Koppes’ research on “Cholinergic Activation of Primary Human Derived Intestinal Epithelium Does Not Ameliorate TNF-α Induced Injury” was published in the latest issue of Cellular and Molecular Bioengineering.
Jun 05, 2020
Advancements in Microphysiological Systems
ChE Assistant Professor Abigail Koppes, Assistant Professor Ryan Koppes, and PhD Student Kyla Nichols’ research on “Recent advancements in microphysiological systems for neural development and disease” was published in the Current Opinion in Biomedical Engineering.