Ryan Koppes
Assistant Professor, Chemical Engineering
Office
- 339 Mugar
- 617.373.8547
Lab
- 111 Mugar
- 617.373.8161
Related Links
Research Focus
Neural interface technology, tissue engineering, and musculoskeletal biomechanics
About
Joined the Chemical Engineering Department in Fall 2015.
Education
- PhD (2013) Rensselaer Polytechnic Institute, Biomedical Engineering
- MS (2010) Rensselaer Polytechnic Institute, Biomedical Engineering, area of concentration: Muscle Tissue Engineering
- BS (2008) Rensselaer Polytechnic Institute, Biomedical Engineering, area of concentration: Biomaterials
Honors & Awards
- NIH National Institute of Biomedical Imaging and Bioengineering Trailblazer Award for New and Early Stage Investigators
- Gilda Barbino Excellence in Mentoring Award
Professional Affiliations
- American Society for Mechanical Engineers
- Biophysical Society
- Biomedical Engineering Society
- Materials Research Society
Research Overview
Neural interface technology, tissue engineering, and musculoskeletal biomechanics
Laboratory for Neuromodulation and Neuromuscular Repair
We study the physical bridge between cells and electronics to improve nerve gap and prosthetic technologies. We’re also interested in neuron interactions with the heart to help relieve the healthcare burden of heart failure. Located in Boston, our group is able to join with other top universities to collaborate on ground breaking research.
Selected Research Projects
- Engineered Probiotics for Closed-Loop Control of Disease-Associated Gut Metabolites in Gut-On-Chip Models
- – co-Principal Investigator, National Institute of Biomedical Imaging and Bioengineering
- Bioengineer Long-lasting 3D Neurovascular Microphysiological System to Model Chronic Inflammation-mediated Neurodegeneration
- – co-Principal Investigator, NASA
- Engineering multifaceted 3D human organ platforms for toxicity testing
- – Principal Investigator, National Institutes of Health
- Novel Transparent, Ultra-soft Neuroelectrode Arrays Based on Nanomeshing Conventional Electrode Materials
- – Co-Principal Investigator, NIH
- Bioengineer Autonomic Neurovascular System to Explore the Innervation of Vascular Grafts
- – Principal Investigator, American Heart Association
- Engineering A Humanized Gut-Enteric-Axis
- – Principal Investigator, National Institutes of Health
Department Research Areas
Selected Publications
- Bindas, Adam J., Kulkarni, Subhash, Koppes, Ryan A., Koppes, Abigail N. (2021). Parkinson’s Disease and the Gut: Models of an Emerging Relationship. Acta Biomaterialia, . 10.1016/J.ACTBIO.2021.03.071
- Diaz Vera, David, Soucy, Jonathan R., Lee, Audrey, Koppes, Ryan A., Koppes, Abigail N. (2021). Light irradiation of peripheral nerve cells: Wavelength impacts primary sensory neuron outgrowth in vitro. Journal of Photochemistry and Photobiology B: Biology, 215,112105. 10.1016/J.JPHOTOBIOL.2020.112105
- Ventre, Daniel M., Cluff, Avery, Gagnon, Christian, Diaz Vera, David, Koppes, Ryan A., Koppes, Abigail N. (2021). The effects of low intensity focused ultrasonic stimulation on dorsal root ganglion neurons and Schwann cells in vitro. Journal of Neuroscience Research, 99(1),374-391. 10.1002/JNR.24700
- S. Hosic, W. Lake, E. Stas, R.A. Koppes, D.T. Breault, S.K. Murthy, A.N. Koppes, Cholinergic Activation of Primary Human Derived Intestinal Epithelium does not Ameliorate TNF-𝛼 Induced Injury, Cellular and Molecular Bioengineering, 2020
- T. Torregrosa, S. Webster, C. Aghaizu, J. Soucy, C. Bertucci, L. Plant, A.N. Koppes, R.A. Koppes Cryopreservation and Functional Analysis of Cardiac Autonomic Neurons, Journal of Neuroscience Methods, 341, 2020, 108724
- J. Snyder, C. Wang, A.Q. Zhang, Y. Li, J. Luchan, S. Hosic, R. Koppes, R.L. Carrier, A. Koppes, Materials and Microenvironments for Engineering the Intestinal Epithelium, Annals of Biomedical Engineering, 48, 2020, 1916–1940
- S. Hosic, A. Bindas, M. Puzan, W. Lake, J. Soucy, F. Zhou, R.A. Koppes, D. Breault, S. Murthy, A.N. Koppes Rapid Prototyping of Multilayer Micro Physiological Systems, ACS Biomaterials Science & Engineering, 2020
- K. Nichols, R. Koppes, A. Koppes, Recent Advancements in Micro Physiological Systems for Neural Development and Disease, Current Opinion in Biomedical Engineering, 14, 2020, 42-51
- A.R. Spencer, E.S. Sani, J.R. Soucy, C.C. Corbet, A. Primebetova, R.A. Koppes, N. Annabi Bioprinting of a Cell-Laden Conductive Hydrogel Composite, ACS Applied Material Interfaces, 11(34), 2019, 30518-30533
- J.R. Soucy, A.J. Bindas, A.N. Koppes, R.A. Koppes Instrumented Micro Physiological Systems for Real- Time Measurement and Manipulation of Cellular Electrochemical Processes, iScience, 21, 2019, 521-548
Jan 25, 2023
Announcing Spring 2023 PEAK Experiences Awardees
Several engineering students and science students mentored by COE faculty are recipients of Northeastern’s Spring 2023 PEAK Experiences Awards. Base Camp Awardees Sophia Nguyen COE’26, “Neuromodulation of Motor Cortex’s Response to Different Transcranial Magnetic Stimulation Pulse Waveforms” Mentor: Mathew Yarossi, Bouvé, Physical Therapy/Movement/Rehab Science This project seeks to use transcranial magnetic stimulation (TMS), a noninvasive […]
Jan 17, 2023
Spring 2023 Spark Fund Awardees
ChE/COS Associate Professor Carolyn Lee-Parsons, ECE Professor Edmund Yeh, ChE Assistant Professor Ryan Koppes, and MIE Associate Professor Yaning Li are recipients of the Spring 2023 Spark Fund Awards.
Dec 07, 2022
NIH Trailblazer Award for Engineering Smarter Gut Metabolites to Affect Human Health
ChE Assistant Professor Benjamin Woolston is leading a $628K NIH Trailerblazer Award with Assistant Professor Ryan Koppes, Associate Professor Abigail Koppes, and Professor Rebecca Carrier for “Engineered Probiotics for Closed-Loop Control of Disease-Associated Gut Metabolites in Gut-On-Chip Models.”
Oct 07, 2022
Announcing Fall 2022 PEAK Experiences Awardees
Several engineering students and science students mentored by COE faculty are recipients of Northeastern’s Fall 2022 PEAK Experiences Awards. This extraordinary group of students is taking on a range of exciting projects, from exploring axolotl limb regeneration to building a snake-inspired robot to understanding accessibility on Broadway. ASCENT AWARDS Justin Almendral COE’24, “Wearable Art” Mentor: […]
Aug 19, 2022
Using Spark Fund Award to Regenerate Nerve Damage
ChE Assistant Professor Ryan Koppes is using the Spark Funds he received earlier this year to develop methods of converting olfactory stem cells into Schwann Cells that can be used to repair nerve damage.
Aug 16, 2022
Abigail Koppes: Advancing Technology, Treatment, and Diversity in Biomedical Engineering
Associate Professor Abigail Koppes, chemical engineering, began her career as a Future Faculty Fellow through Northeastern’s ADVANCE Office of Faculty Development. Today she is an associate professor, has two patents, and numerous young investigator recognitions.
Aug 11, 2022
GelMA/MeTro Composites for Peripheral Nerve Repair
ChE Associate Professor Abigail Koppes and Assistant Professor Ryan Koppes were awarded a patent for creating “Gelatin/elastin composites for peripheral nerve repair.”
Jun 09, 2022
Improving Fluidic Devices for Cell Cultures
ChE Assistant Professor Ryan Koppes and Associate Professor Abigail Koppes were awarded a patent for designing a “Fluidic device and method of assembling same.”
May 18, 2022
Announcing Summer 2022 PEAK Experiences Awardees
Several engineering students and science students mentored by COE faculty are recipients of Northeastern’s Summer 2022 PEAK Experiences Awards.
Apr 04, 2022
$2M NASA Grant To Build Long Lasting Neurovascular Model
BioE Associate Professor Guohao Dai, ChE Associate Professor Abigail Koppes, and ChE Assistant Professor Ryan Koppes received a $2M grant from NASA titled “Bioengineer Long-lasting 3D Neurovascular Microphysiological System to Model Chronic Inflammation-mediated Neurodegeneration”.