Ryan Koppes

Assistant Professor,  Chemical Engineering

Contact

Social Media

Office

  • 339 Mugar
  • 617.373.8547

Lab

  • 111 Mugar
  • 617.373.8161

Research Focus

neural interface technology, tissue engineering, and musculoskeletal biomechanics

About

Joined the Chemical Engineering Department in Fall 2015.

Education

  • PhD (2013) Rensselaer Polytechnic Institute, Biomedical Engineering
  • MS (2010) Rensselaer Polytechnic Institute, Biomedical Engineering, area of concentration: Muscle Tissue Engineering
  • BS (2008) Rensselaer Polytechnic Institute, Biomedical Engineering, area of concentration: Biomaterials

Honors & Awards

  • NIH National Institute of Biomedical Imaging and Bioengineering Trailblazer Award for New and Early Stage Investigators

Professional Affiliations

  • American Society for Mechanical Engineers
  • Biophysical Society
  • Biomedical Engineering Society
  • Materials Research Society

Research Overview

neural interface technology, tissue engineering, and musculoskeletal biomechanics

Laboratory for Neuromodulation and Neuromuscular Repair

We study the physical bridge between cells and electronics to improve nerve gap and prosthetic technologies. We’re also interested in neuron interactions with the heart to help relieve the healthcare burden of heart failure. Located in Boston, our group is able to join with other top universities to collaborate on ground breaking research.

Laboratory for Neuromodulation and Neuromuscular Repair

Selected Research Projects

College Research Initiatives

Selected Publications

  • S. Hosic, W. Lake, E. Stas, R.A. Koppes, D.T. Breault, S.K. Murthy, A.N. Koppes, Cholinergic Activation of Primary Human Derived Intestinal Epithelium does not Ameliorate TNF-𝛼 Induced Injury, Cellular and Molecular Bioengineering, 2020
  • T. Torregrosa, S. Webster, C. Aghaizu, J. Soucy, C. Bertucci, L. Plant, A.N. Koppes, R.A. Koppes Cryopreservation and Functional Analysis of Cardiac Autonomic Neurons, Journal of Neuroscience Methods, 341, 2020, 108724
  • J. Snyder, C. Wang, A.Q. Zhang, Y. Li, J. Luchan, S. Hosic, R. Koppes, R.L. Carrier, A. Koppes, Materials and Microenvironments for Engineering the Intestinal Epithelium, Annals of Biomedical Engineering, 48, 2020, 1916–1940
  • S. Hosic, A. Bindas, M. Puzan, W. Lake, J. Soucy, F. Zhou, R.A. Koppes, D. Breault, S. Murthy, A.N. Koppes Rapid Prototyping of Multilayer Micro Physiological Systems, ACS Biomaterials Science & Engineering, 2020
  • K. Nichols, R. Koppes, A. Koppes, Recent Advancements in Micro Physiological Systems for Neural Development and Disease, Current Opinion in Biomedical Engineering, 14, 2020, 42-51
  • A.R. Spencer, E.S. Sani, J.R. Soucy, C.C. Corbet, A. Primebetova, R.A. Koppes, N. Annabi Bioprinting of a Cell-Laden Conductive Hydrogel Composite, ACS Applied Material Interfaces, 11(34), 2019, 30518-30533
  • J.R. Soucy, A.J. Bindas, A.N. Koppes, R.A. Koppes Instrumented Micro Physiological Systems for Real- Time Measurement and Manipulation of Cellular Electrochemical Processes, iScience, 21, 2019, 521-548
student working in chemical engineering lab

Spotlight Story

Oct 02, 2020

PhD Spotlight: Jonathan Soucy, PhD’20 – Chemical Engineering

Advised by Assistant Professor Ryan Koppes, Chemical Engineering After receiving his bachelor’s degree in chemical engineering from Rensselaer Polytechnic Institute in 2015, Jonathan Soucy joined Northeastern University pursuing a PhD in chemical engineering. His research has focused on neurochemistry, specifically on the sympathetic and parasympathetic nerve systems—the mechanisms by which the brain controls the speed […]

Faculty

Sep 16, 2020

Koppes and Bencherif Published in Bioelectricity

ChE Assistant Professors Ryan Koppes and Sidi A. Bencherif were published in Bioelectricity for their research on “Electroconductive Hydrogels for Tissue Engineering: Current Status and Future Perspectives.”

cover of Advanced BioSystems journal

Faculty

Sep 03, 2020

Abigail and Ryan Koppes Featured on Inside Front Cover of Advanced Biosystems

ChE Assistant Professors Abigail Koppes and Ryan Koppes’ research on “Reconfigurable Microphysiological Systems for Modeling Innervation and Multitissue Interactions” was published in the September issue of Advanced Biosystems.

Faculty

Sep 03, 2020

Fang and Koppes Receive $2.2M NIH Award Leading to State-of-the-Art Electrophysiological Capabilities

ECE Assistant Professor Hui Fang (PI) and ChE Assistant Professor Ryan Koppes (co-PI), in collaboration with UCLA and Boston Children’s Hospital, received a $2.2M NIH grant for “Novel transparent, ultra-soft neuroelectrode arrays based on nanomeshing conventional electrode materials.” In this study, they propose to prove a novel electrode concept, nanomeshing conventional electrode materials, can lead to state-of-the-art electrophysiological capabilities while allowing at the same time, optical and chronic-bio- compatibilities. Besides enabling new hypothesis-driven neuroscience studies from overcoming major barriers of integrating in-vivo electrical recordings with optical approaches, the proposed research will also provide unique opportunities for next-generation therapeutic interventions via sustainable neural prosthetics.

male and female professor posing in their chemical engineering lab with microscope in background

Faculty

Aug 13, 2020

Abigail Koppes and Ryan Koppes Published in the Journal of Neuroscience Research

ChE Assistant Professors Abigail Koppes and Ryan Koppes published their research in the Journal of Neuroscience titled: “The effects of low intensity focused ultrasonic stimulation on dorsal root ganglion neurons and Schwann cells in vitro.”

professors posing in chemical engineering lab

Faculty

Jul 16, 2020

Cryopreservation of Cardiac Autonomic Neurons

ChE Assistant Professor Abigail Koppes and Assistant Professor Ryan Koppes’ research on “Cryopreservation and functional analysis of cardiac autonomic neurons” was published in the Journal of Neuroscience Methods.

professors posing in chemical engineering lab

Faculty

Jun 24, 2020

Investigating Intestinal Inflammation

ChE Assistant Professor Abigail Koppes and Assistant Professor Ryan Koppes’ research on “Cholinergic Activation of Primary Human Derived Intestinal Epithelium Does Not Ameliorate TNF-α Induced Injury” was published in the latest issue of Cellular and Molecular Bioengineering.

slide illustrating neural microphysological research

Faculty

Jun 05, 2020

Advancements in Microphysiological Systems

ChE Assistant Professor Abigail Koppes, Assistant Professor Ryan Koppes, and PhD Student Kyla Nichols’ research on “Recent advancements in microphysiological systems for neural development and disease” was published in the Current Opinion in Biomedical Engineering.

In the Media

May 29, 2020

Why I paused my Ph.D. research to work as an industry intern

ChE PhD student Tess Torregrosa wrote an editorial in Science Magazine on “Why I paused my Ph.D. research to work as an industry intern“, Tess was co-advised by Assistant Professors Ryan Koppes and Abigail Koppes.

graphic of multilayer physiological systems

Faculty

May 21, 2020

Rapid Prototyping of Multilayer Microphysiological Systems

ChE Assistant Professor Ryan Koppes, Assistant Professor Abigail Koppes, and PhD students were published in ACS Biomaterials Science & Engineering for their research on “Rapid Prototyping of Multilayer Microphysiological Systems”. Abstract Source: ACS Microfluidic organs-on-chips aim to realize more biorelevant in vitro experiments compared to traditional two-dimensional (2D) static cell culture. Often such devices are […]

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