Mingyang Lu
Assistant Professor, Bioengineering
Research Focus
computational systems biology, an integration of mathematical modeling and bioinformatics for studying gene regulatory networks, single cell genomics, epithelial-mesenchymal transition, coarse-graining, reverse engineering, machine learning, stochasticity and heterogeneity in gene expression
Education
- PhD, Biochemistry and Molecular Biology, Biophysics Track, Baylor College of Medicine Houston, TX 2010
Research Overview
computational systems biology, an integration of mathematical modeling and bioinformatics for studying gene regulatory networks, single cell genomics, epithelial-mesenchymal transition, coarse-graining, reverse engineering, machine learning, stochasticity and heterogeneity in gene expression
Selected Research Projects
- New Computational Systems Biology Methods for Modeling Gene Regulatory Circuits
Principle Investigator, National Institutes of Health
Department Research Areas
Selected Publications
- A. Katebi, V. Kohar, M. Lu, Random Parametric Perturbations of Gene Regulatory Circuit Uncover State Transitions in Cell Cycle, iScience, 23(6), 2020, 101150
- D. Ramirez, V. Kohar, M. Lu, Toward Modeling Context-Specific EMT Regulatory Networks Using Temporal Single Cell RNA-Seq Data, Front Mol Biosci, 7, 2020, 54
- D. Jia, M. Lu, K.H. Jung, J.H. Park, L. Yu, J. Onuchic, B.A. Kaipparettu, H. Levine, Elucidating Cancer Metabolic Plasticity by Coupling Gene Regulation with Metabolic Pathways, Proceedings of the National Academy of Sciences of the United States of America, 116(9), 2019, 3909-18
- V. Kohar, M. Lu., Role of Noise and Parametric Variation in the Dynamics of Gene Regulatory Circuits, NPJ Systems Biology and Applications, 4(40), 2018
- B. Huang, M. Lu, D. Jia, E. Ben-Jacob, H. Levine, J. Onuchic, Interrogating the Topological Robustness of Gene Regulatory Circuits by Randomization, PLOS Computational Biology, 13(3), 2017, e1005456
- L. Yu, M. Lu, D. Jia, J. Ma, E. Ben-Jacob, H. Levine, B.A. Kaipparettu, J. Onuchic, Modeling the Genetic Regulation of Cancer Metabolism: Interplay Between Glycolysis and Oxidative Phosphorylation, Cancer Research, 77(7), 2017, 1564
Oct 16, 2020
COE Faculty Awarded Seed Funding in Collaboration with University of Maine
BioE Assistant Professors Jiahe Li and Mingyang Lu, ECE Professor & Chair Srinivas Tadigadapa, ECE Assistant Professors Sarah Ostadabbas and Xue “Shelley” Lin, and ECE Associate Research Scientist Ataur Katebi were among the faculty chosen for five competitive collaborative research projects with the University of Maine in the areas of artificial intelligence, earth and climate sciences, health and life sciences, manufacturing, and marine sciences.
Oct 01, 2020
Assuring that Self-Driving Cars are Accessible to Those with Disabilities
ECE Assistant Professor Xue “Shelley” Lin is working with the algorithms in self-driving vehicles to ensure that they will be accessible to those with disabilities.
Sep 02, 2020
New Faculty Spotlight: Mingyang Lu
Mingyang Lu joins the Bioengineering department in August 2020 as an Assistant Professor.