Mingyang Lu
Assistant Professor, Bioengineering
Office
- 177 Huntington Ave, # 1319
Research Focus
Computational systems biology, an integration of mathematical modeling and bioinformatics for studying gene regulatory networks, single cell genomics, epithelial-mesenchymal transition, coarse-graining, reverse engineering, machine learning, stochasticity and heterogeneity in gene expression
About
Mingyang Lu received his BS degree in Physics at Fudan University in 2003 and obtained his PhD degree in Biochemistry and Molecular Biology at Baylor College of Medicine in 2010. Since 2016, he has established his independent research lab as an Assistant Professor at The Jackson Laboratory before joining the Bioengineering department at Northeastern. Dr. Lu’s research interests include methodology development in computational systems biology and applications to model gene regulatory networks driving cellular state transitions by integrating genomics data analysis and mathematical modeling. Lu has received a five-year Maximizing Investigators’ Research Award (MIRA) from the National Institute of General Medical Sciences.
Education
- PhD, Biochemistry and Molecular Biology, Biophysics Track, Baylor College of Medicine Houston, TX 2010
Teaching Interests
Physical Bioengineering
Research Overview
Computational systems biology, an integration of mathematical modeling and bioinformatics for studying gene regulatory networks, single cell genomics, epithelial-mesenchymal transition, coarse-graining, reverse engineering, machine learning, stochasticity and heterogeneity in gene expression
Selected Research Projects
- Genome Editing Approaches to Unravel microRNA Roles in Stochastic Multistable Networks
- – Principal Investigator, National Science Foundation
- New Computational Systems Biology Methods for Modeling Gene Regulatory Circuits
- – Principle Investigator, National Institutes of Health
- Collaborative Research: Genome editing approaches to unravel microRNA roles in stochastic multistable networks
- – Principle Investigator, National Sciences Foundation
Research Centers and Institutes
Center for Theoretical Biological Physics
Department Research Areas
Selected Publications
- A. Katebi, D. Ramirez, and M. Lu. Computational systems-biology approaches for modeling gene networks driving epithelial–mesenchymal transitions. Comput. Syst. Oncol. 1(2), 2021, e1021
- V. Kohar, D. Gordin, A. Ketabi and M. Lu. Gene Circuit Explorer (GeneEx): an interactive web-app and database for visualizing, simulating and analyzing gene regulatory circuits. Bioinformatics. 37(9), 2021, 1327-29
- A. Katebi, V. Kohar, M. Lu, Random Parametric Perturbations of Gene Regulatory Circuit Uncover State Transitions in Cell Cycle, iScience, 23(6), 2020, 101150
- D. Ramirez, V. Kohar, M. Lu, Toward Modeling Context-Specific EMT Regulatory Networks Using Temporal Single Cell RNA-Seq Data, Front Mol Biosci, 7, 2020, 54
- D. Jia, M. Lu, K.H. Jung, J.H. Park, L. Yu, J. Onuchic, B.A. Kaipparettu, H. Levine, Elucidating Cancer Metabolic Plasticity by Coupling Gene Regulation with Metabolic Pathways, Proceedings of the National Academy of Sciences of the United States of America, 116(9), 2019, 3909-18
- V. Kohar, M. Lu., Role of Noise and Parametric Variation in the Dynamics of Gene Regulatory Circuits, NPJ Systems Biology and Applications, 4(40), 2018
- B. Huang, M. Lu, D. Jia, E. Ben-Jacob, H. Levine, J. Onuchic, Interrogating the Topological Robustness of Gene Regulatory Circuits by Randomization, PLOS Computational Biology, 13(3), 2017, e1005456
- L. Yu, M. Lu, D. Jia, J. Ma, E. Ben-Jacob, H. Levine, B.A. Kaipparettu, J. Onuchic, Modeling the Genetic Regulation of Cancer Metabolism: Interplay Between Glycolysis and Oxidative Phosphorylation, Cancer Research, 77(7), 2017, 1564
Jul 15, 2021
Understanding microRNA Roles in Stochastic Multistable Networks
BioE Assistant Professor Mingyang Lu and Physics/BioE University Distinguished Professor Herbert Levine, in collaboration with Leonidas Bleris from the University of Texas at Dallas, were awarded a $1.4M NSF grant for “Genome Editing Approaches to Unravel microRNA Roles in Stochastic Multistable Networks.”
Oct 16, 2020
COE Faculty Awarded Seed Funding in Collaboration with University of Maine
BioE Assistant Professors Jiahe Li and Mingyang Lu, ECE Professor & Chair Srinivas Tadigadapa, ECE Assistant Professors Sarah Ostadabbas and Xue “Shelley” Lin, and ECE Associate Research Scientist Ataur Katebi were among the faculty chosen for five competitive collaborative research projects with the University of Maine in the areas of artificial intelligence, earth and climate sciences, health and life sciences, manufacturing, and marine sciences.
Oct 01, 2020
Assuring that Self-Driving Cars are Accessible to Those with Disabilities
ECE Assistant Professor Xue “Shelley” Lin is working with the algorithms in self-driving vehicles to ensure that they will be accessible to those with disabilities.
Sep 02, 2020
New Faculty Spotlight: Mingyang Lu
Mingyang Lu joins the Bioengineering department in August 2020 as an Assistant Professor.