Bryan Spring

Affiliated Faculty,  Bioengineering
Assistant Professor,  Physics



  • 617.373.5303

Research Focus

targeted photomedicine, biophysical microscopy and cancer biology


  • PhD, University of Illinois 2008

Honors & Awards

  • Smith Family Awards Program for Excellence in Biomedical Research
  • The National Cancer Institute Transition Career Development Award

Research Overview

targeted photomedicine, biophysical microscopy and cancer biology

Selected Research Projects

  • Multiplexed and Dynamically Targeted Photoimmunotherapy of Heterogeneous, Chemo-resistant Micrometastases Guided by Online In Vivo Optical Imaging of Cell-Surface Biomarkers
    • – Principal Investigator, National Cancer Institute
  • Peering into Cancer Stem Cell Niches to Guide Suppression of Multiple Signaling Loop Pathways
    • – Principal Investigator, Richard and Susan Smith Family Foundation

Selected Publications

  • E.M. Kercher, S. Nath, I. Rizvi, B.Q. Spring Cancer Cell-Targeted and Activatable Photoimmunotherapy Spares T Cells in a 3D Co-Culture Model, Photochemistry and Photobiology, 96(2), 2020, 295–300
  • N. Davoudzadeh, G. Ducourthial, B.Q. Spring, Custom Fabrication and Mode-Locked Operation of a Femtosecond Fiber Laser for Multiphoton Microscopy, Scientific Reports, 9, 2019, 4233
  • B.Q. Spring, R.B. Sears, L.Z. Zheng, Z.Mai, R. Watanabe, M.E. Sherwood, D.A. Schoenfeld, B.W. Pogue, S.P. Pereira, E. Villa, T. Hasan, A Photoactivable Multi-Inhibitor Nanoliposome for Tumour Control and Simultaneous Inhibition of Treatment Escape Pathways, Nature Nanotechnology, 11(4), 2016, 378
  • B.Q. Spring, A.O. Abu-Yousif, A. Palanisami, I. Rizvi, X. Zheng, Z. Mai, S. Anbil, R.B. Sears, L.B. Mensah, R. Goldschmidt, S.S. Erdem, E. Oliva E, T. Hasan Selective Treatment and Monitoring of Disseminated Cancer Micrometastases in Vivo using Dual-Function, Activatable Immunoconjugates, Proceedings of the National Academy of Sciences of the United States of America, 111(10), 2014, E933–E942


Apr 27, 2023

FY24 TIER 1 Award Recipients

Twelve COE faculty and affiliates were recipients of FY24 TIER 1 Interdisciplinary Research Seed Grants for 11 different projects.


Apr 27, 2023

Announcing Summer 2023 PEAK Experiences Awardees

Several engineering students and science students mentored by COE faculty are recipients of Northeastern’s Summer 2023 PEAK Experiences Awards. They will be pursuing a diverse set of projects, including a study of a pathogen that haunts hospitals, an examination of segregationist rhetoric in Boston newspapers, and an analysis of creativity in music.

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