Paul Whitford
Affiliated Faculty, Bioengineering
Associate Professor, Physics
Contact
- p.whitford@northeastern.edu
- 111 DA
360 Huntington Avenue
Boston, Massachusetts 02115
Office
- 617.373.2952
Research Focus
dynamics of large-scale molecular machines, working to identify the physical principles that guide biomolecular dynamics, using molecular simulation approaches to interpret experimental data from a wide range of techniques, including biochemical, small-angle X-ray scattering and cryogenic electron microscopy
Research Overview
dynamics of large-scale molecular machines, working to identify the physical principles that guide biomolecular dynamics, using molecular simulation approaches to interpret experimental data from a wide range of techniques, including biochemical, small-angle X-ray scattering and cryogenic electron microscopy
Selected Research Projects
- Disorder, tRNA Composition and Energy Transduction in the Ribosome
- – Principal Investigator, National Science Foundation
- Quantifying the Effects of Ions and Collective Rearrangements During Ribosome Function
- – Principal Investigator, National Science Foundation
Selected Publications
- P. Waduge, R. Hu, P. Bandarkar, H. Yamazaki, B. Cressiot, Q. Zhao, P.C. Whitford, M. Wanunu, Nanopore-Based Measurements of Protein Size, Fluctuations, and Conformational Changes, ACS Nano, 11, 2017, 5706-5716
- M. Levi, K. Nguyen, L. Dukaye, P.C. Whitford. Quantifying the Relationship Between Single-Molecule Probes and Subunit Rotation in the Ribosome, Biophysical Journal, 113, 2017, 2777-2786
- K. Nguyen, P.C. Whitford, Steric Interactions Lead to Collective Head Tilting During mRNA-tRNA Translocation on the Ribosome, Nature Communications, 7, 2016, 10586
- J.K. Noel, P.C. Whitford, How EF-Tu Can Contribute to Efficient Proofreading of aa-tRNA by the Ribosome, Nature Communications, 7, 2016, 13314
- P.C. Whitford, Disorder Guides Protein Function, Proceedings of the National Academy of Sciences USA, 110, 2013, 7114-7115