Mansoor Amiji
University Distinguished Professor,
Pharmaceutical Sciences
University Distinguished Professor,
Chemical Engineering
Affiliated Faculty,
Bioengineering
Contact
- m.amiji@northeastern.edu
- 360 Huntington Avenue
Boston, MA 02115
Office
- 140 The Fenway, Room 165
- 617.373.3137
Research Focus
Polymeric biomaterials, drug delivery systems, nanomedical technologies
Education
- BS, Pharmacy (magna cum laude), Northeastern University
- PhD, Pharmaceutics, Purdue University
Honors & Awards
- T. Nagai Award, Controlled Release Society
- Fellow, America Association of Pharmaceutical Scientists (AAPS)
- Fellow, American Institute for Medical and Biological Engineers (AIMBE)
- Fellow, Controlled Release Society
- Charivate Analytics Highly Cited Author (top 1%)
- Distinguished Alumni Award, Purdue University College of Pharmacy
Professional Affiliations
- American Association of Pharmaceutical Scientists, Fellow
- Controlled Release Society, Fellow
Research Overview
Polymeric biomaterials, drug delivery systems, nanomedical technologies
Translational Therapeutic Delivery Laboratory
Success in pharmaceutical and biotechnology product development requires safe and efficient delivery of the therapeutic agent to its target site, which may be quite remote from the administration site. Currently, there are two main challenges in drug delivery: (1) hard-to-deliver molecules and (2) hard-to-reach target sites in the body.
At Northeastern University, we explore customized, innovative solutions to deliver therapeutic and vaccine payloads to their target sites (e.g., brain). Challenging biological molecules such as proteins, peptides, and nucleic acids require efficient delivery modalities to enable their therapeutic functions.
Our approach focuses on multidisciplinary expertise in science and engineering and active collaborations with medical professionals and industrial scientists toward successful product development that can benefit patients.
Selected Research Projects
- Combination Strategy for the Treatment of Advanced Pancreatic Cancer
- – Principal Investigator, National Institutes of Health
- Development and Validation of a Novel Cas13a and Nanoparticle Guide-RNA Delivery System that Allows Precise Ablation of Host Macrophage Populations in a Humanized Mouse Model
- – Principal Investigator, Jackson Laboratories on a National Institutes of Health
- Direct CNS Delivery System for BDNF AntagoNATs using Heterotopic Mucosal Grafting for the Treatment of Parkinson’s Disease
- – Principal Investigator, National Institutes of Health
Department Research Areas
Selected Publications
- Bitounis, D., Amiji, M.M. Lipid nanoparticles target haematopoietic stem cells. Nat. Nanotechnol. (2024). https://doi.org/10.1038/s41565-024-01682-6
- J. Bae, N. Parayath, W. Ma, M. Amiji, N. Munshi, K. Anderson, Bcma Peptide Engineered Nanoparticles Enhance Induction and Function of Antigen Specific Cd8+ Cytotoxic T Lymphocytes Against Multiple Myeloma, Nature – Leukemia, 34, 2020, 210–223
- N.N. Parayath, S. Padmakumar, M. Amiji, Extracellular Vesicle-Mediated Nucleic Acid Transfer and Reprogramming in the Tumor Microenvironment, Cancer Letters, 482(10), 2020, 33-43
- G. Ahmad, G. Mackenzie, J. Egan, M. Amiji, Dha-Sbt-1214 Taxoid Nanoemulsion and Anti-Pd-L1 Antibody Combination Therapy Enhances Antitumor Efficacy in a Syngeneic Pancreatic Adenocarcinoma Model, Molecular Cancer Therapeutics, 18(11), 2019, 961-1972
- D. Chen, N. Parayath, S. Ganesh, W. Wang, M. Amiji, Role of Apolipoprotein-and Vitronectin-Enriched Protein Corona on Lipid Nanoparticles for in Vivo Targeted Delivery and Transfection of Oligonucleotides in Murine Tumor Models, Nanoscale, 11, 2019, 18806–18824
Jan 31, 2025
Bypassing Blood-Brain Barrier for Targeted Brain Therapy
Bouvé/ChE University Distinguished Professor Mansoor Amiji’s research on the “Effective Nose-to-Brain Delivery of Blood-Brain Barrier Impermeant Anti-IL-1β Antibody via the Minimally Invasive Nasal Depot (MIND) Technique” was published in ACS Applied Materials & Interfaces.
Jan 31, 2025
Improving Drug Delivery to the Brain
Bouvé/ChE University Distinguished Professor Mansoor Amiji’s research on the “Murine Model of Minimally Invasive Nasal Depot (MIND) Technique for Central Nervous System Delivery of Blood–Brain Barrier-Impermeant Therapeutics” was published in Lab Animal.
Jan 31, 2025
2024 Stanford University Annual Assessment of Author Citations
The following COE professors are among the top scientists worldwide selected by Stanford University representing the top 2% of the most-cited scientists with single-year impact in various disciplines. The selection is based on the top 100,000 by c-score (with and without self-citations) or a percentile rank of 2% or above. The list below includes those who published a paper in 2024 or later.
Jan 31, 2025
Treating Lung Diseases Using Nanotechnology
Bouvé/ChE University Distinguished Professor Mansoor Amiji’s research on the “Interplay of Nano-based Delivery Systems and Protein Signalling in Ameliorating Lung Diseases” was published in Journal of Drug Delivery Science and Technology.
Jan 31, 2025
Improving Vaccine Adjuvant Production Methods
Bouvé/ChE University Distinguished Professor Mansoor Amiji’s research on “Microfluidic-Chip-Based Formulation and In Vivo Evaluations of Squalene Oil Emulsion Adjuvants for Subunit Vaccines” was published in Vaccines.
Jan 09, 2025
Patent for Combining Drugs and Immunotherapy for Cancer Treatment
Bouvé/ChE University Distinguished Professor Mansoor Amiji was awarded a patent for “Combination taxoid nanoemulsion with immunotherapy in cancer.”
Oct 24, 2024
Advising Against Microdosing Diabetes Drugs for Weight-Loss Treatment
Bouvé/ChE University Distinguished Professor Mansoor Amiji cautions against microdosing diabetes drugs such as Ozempic for weight-loss treatment, saying there is limited clinical data to support its effectiveness despite increased interest as a way to avoid high prices and unwanted side effects.
Oct 23, 2024
Patent for Trans-Nasal Brain Drug Delivery System
Bouvé/ChE University Distinguished Professor Mansoor Amiji was awarded a patent for “Biodegradable implant for sustained trans-nasal delivery of therapeutic agents to the brain.”
Sep 11, 2024
Pioneering Innovative Treatments for GI Diseases
Bouvé/ChE University Distinguished Professor Mansoor Amiji is developing innovative oral nucleic acid delivery systems to revolutionize treatment for gastrointestinal (GI) diseases that aim to deliver genetic medicines directly to the affected areas within the GI tract.
Aug 22, 2024
Nasal Epinephrine Spray Alternative to EpiPen
Bouvé/ChE University Distinguished Professor Mansoor Amiji says a new epinephrine nasal spray recently approved by the FDA is a smaller and less costly device than the EpiPen and doesn’t involve an injection, which could appeal to many people.