Guohao Dai
Professor,
Bioengineering
Office
- 224 ISEC
- 617.373.2207
Research Focus
3-D bioprinting technology, stem cells technology and vascular bioengineering
Education
- Post-doc, Vascular Biology, Harvard Medical School
- Ph.D, Biomedical Engineering, Massachusetts Institute of Technology
- M.S, Biomechanics, Peking University
- B.S, Mechanical Engineering, Peking University
Honors & Awards
- 2012 National Scientist Development Award, American Heart Association
- 2014 NSF Career Award
- 2015 Rising Star Award, Biomedical Engineering Society Cellular and Molecular Bioengineering
- 2015 The Institute’s James M. Tien ’66 Faculty Early Career Award, Rensselaer Polytechnic Institute
- 2018 College of Engineering Faculty Fellow
- 2018 Fellow American Heart Association
- 2022-2025 Biomedical Engineering Society (BMES) Board of Directors
- 2023 American Institute for Medical and Biological Engineering (AIMBE) Fellow
- 2024 Biomedical Engineering Society (BMES) Fellow
Professional Affiliations
- American Heart Association, Fellow
- Biomedical Engineering Society
- North American Vascular Biology Organization
Research Overview
3-D bioprinting technology, stem cells technology and vascular bioengineering
Guohao Dai Lab
Blood vessels play an increasingly important role in most human tissue and organ systems. Importantly, vascular niche was found to be a key element of many stem cell environments such as neural stem cells. Vascular cells not only form conduits to deliver nutrient and oxygen, but also provide instructive signals to control stem cell self-renewal and differentiation, therefore, is critical for tissue regeneration. The mission of Vascular Bioengineering Laboratory is integrate bioengineering approaches with stem cells and vascular biology to understand blood vessel regeneration and vascular disease processes, and to develop novel therapeutic modalities to treat vascular-related disorders such as cardiovascular, neurovascular and cancer.
Selected Research Projects
- Bioengineer Long-lasting 3D Neurovascular Microphysiological System to Model Chronic Inflammation-mediated Neurodegeneration
- – Principal Investigator, NASA
- CAREER: Engineer a Functional 3-D Vascular Niche to Support Neural Stem Cell Self-Renewal
- – Principal Investigator, National Science Foundation
- Differentiation Arterial and Venous Endothelial Cells from Embryonic Stem Cells
- – Principal Investigator, National Institutes of Health
- Elastic Printable Biomaterials for 3-D Bioprinting of Vascular Conduit
- – Principal Investigator, National Institutes of Health
- Transcriptional Regulation of Arterial Venous Differentiation
- – Principal Investigator, American Heart Association
Research Centers and Institutes
Department Research Areas
Selected Publications
- Baltazar, Tânia, Merola, Jonathan, Catarino, Carolina, Xie, Catherine B., Kirkiles-Smith, Nancy C., Lee, Vivian, Hotta, Stephanie, Dai, Guohao, Xu, Xiaowei, Ferreira, Frederico C., Saltzman, W. Mark, Pober, Jordan S., Karande, Pankaj (2020). Three Dimensional Bioprinting of a Vascularized and Perfusable Skin Graft Using Human Keratinocytes, Fibroblasts, Pericytes, and Endothelial Cells. Tissue Engineering, 26(5-6),227-238. 10.1089/TEN.TEA.2019.0201
- M.S. Ozturk, V.K. Lee, H. Zou, R.H. Friedel, X.Intes, G.Dai High Resolution Tomographic Analysis of in vitro 3D Glioblastoma Tumor Model under Long-Term Drug Treatment, Science Advances, 6(10), 2020, 7513
- W. Song, A. Chiu, L.-H. Wang, R.E. Schwartz, B. Li, N. Bouklas, D.T. Bowers, V.K. Lee, G. Dai, M. Ma, et al. Engineering Transferrable Microvascular Meshes for Subcutaneous Islet Transplantation, Nature Communications, 10, 2019, 4602
- L. Niklason, G. Dai, Arterial Venous Differentiation for Vascular Bioengineering, Annual Review of Biomedical Engineering, 2018, 4(20), 431-447
- C. Xu, W. Lee, G. Dai, Y. Hong, Highly Elastic Biodegradable Single-Network Hydrogel for Cell Printing, ACS Applied Materials & Interfaces, 10(12), 2018, 9969-9979
- T.B. Dorsey, D. Kim, A. Grath, D. James, G. Dai Multivalent Biomaterial Platform to Control the Distinct Arterial Venous Differentiation of Pluripotent Stem Cells, Biomaterials, 2018, 185, 1-12
Sep 25, 2024
Fall 2024 PEAK Experiences Awardees for Undergrad Research
Several COE, COS, and Khoury students mentored by COE faculty are recipients of the Fall 2024 PEAK Experiences Awards from Northeastern’s Office of Undergraduate Research and Fellowships.
Sep 24, 2024
Dai Selected as BMES Fellow
BioE Professor Guohao Dai was selected as a Fellow of the Biomedical Engineering Society (BMES) for contributions in vascular mechanobiology, 3D bioprinting vascular networks for tissue engineering, regenerative medicine applications, and transcriptional regulation of arterial venous vascular differentiation in health and diseases.
Feb 02, 2024
Patent for Developing Biodegradable Elastic Hydrogels for 3D Tissue Engineering
BioE Professor Guohao Dai was awarded a patent for “Biodegradable elastic hydrogels for bioprinting.”
Dec 07, 2023
2023 Stanford University Annual Assessment of Author Citations
The following COE professors are among the top scientists worldwide selected by Stanford University representing the top 2% of the most-cited scientists with single-year impact in various disciplines. The selection is based on the top 100,000 by c-score (with and without self-citations) or a percentile rank of 2% or above.
Mar 28, 2023
Dai and Huang-Saad Named AIMBE Fellows
BioE Associate Professors Guohao Dai and Aileen Huang-Saad were named American Institute for Medical and Biological Engineering (AIMBE) Fellows. Election to the AIMBE College of Fellows is among the highest professional distinctions accorded to a medical and biological engineer, which is comprised of the top 2% of medical and biological engineers.
Nov 02, 2022
2022 Stanford University Annual Assessment of Author Citations
A group of COE professors are among the top scientists worldwide selected by Stanford University representing the top 2% of the most-cited scientists with single-year impact in various disciplines. The selection is based on the top 100,000 by c-score (with and without self-citations) or a percentile rank of 2% or above.
Aug 10, 2022
Dai Selected for BMES Board of Directors
BioE Associate Professor Guohao Dai was selected to be on the Biomedical Engineering Society (BMES) Board of Directors. He will assume the position after the annual meeting in October.
May 18, 2022
Summer 2022 PEAK Experiences Awardees for Undergrad Research
Several engineering and science students mentored by COE faculty are recipients of Northeastern’s Summer 2022 PEAK Experiences Awards from the Office of Undergraduate Research and Fellowships.
Apr 21, 2022
DoD Discovery Award to Develop Human Vascular Malformation Model From iPSCs
BioE Associate Professor Guohao Dai received a $314K Discovery Award from the Department of Defense for “Human iPSCs derived 3D perfused model of vascular malformation”.
Apr 04, 2022
$2M NASA Grant To Build Long Lasting Neurovascular Model
BioE Associate Professor Guohao Dai, ChE Associate Professor Abigail Koppes, and ChE Assistant Professor Ryan Koppes received a $2M grant from NASA titled “Bioengineer Long-lasting 3D Neurovascular Microphysiological System to Model Chronic Inflammation-mediated Neurodegeneration”.