Abigail N. Koppes

Associate Professor,  Chemical Engineering
Affiliated Faculty,  Bioengineering

Contact

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Office

  • 340 Mugar
  • 617.373.6221

Lab

  • 111 Mugar
  • 617.373.8161

Research Focus

bioelectric medicine, development of novel interventions and tissue engineered platforms for nerve regeneration and repair, body-on-a-chip for enteric-gut interactions

About

Joined the Chemical Engineering Department in Fall 2014.

The main focus of the Advanced Biomaterials for NeuroEngineering Laboratory (ABNEL) is advancing treatments for persons suffering from debilitating disorders and injuries of the central and peripheral nervous system. Using a combinatorial approach, we seek to create therapeutic strategies for improved nerve guidance channels that incorporate biomaterial manufacturing, biophysical (optogenetics) cues, structural (nanotopography) cues, and/or biochemical (cytokine) stimulation to modulate neuronal and non-neuronal support cell behavior. We are interested in probing the underlying mechanisms of neural growth and regeneration while engineering future modalities for neural tissue engineering applications.

Through tissue engineering of the enteric nervous system, the ‘Brain in the Gut,’ we hope to improve drug discovery platforms and regenerative medicine interventions for the millions of people suffering from disorders of the gastrointestinal tract, such as irritable bowel diseases. This work will combine primary small intestinal organoid culture with neuro-engineering techniques to recapitulate this complex biological system. Ultimately, we aim to understand the underlying mechanisms of cellular responses to engineered systems and their native biological niches towards rationally designed therapies. Our research utilizes techniques from bioengineering, chemical engineering, materials science, and cellular, molecular, and systems biology.

Education

  • B.S. (Biomedical Engineering) Rensselaer Polytechnic Institute, 2007
  • M.S. (Biomedical Engineering) Rensselaer Polytechnic Institute, 2010
  • PhD (Biomedical Engineering) Rensselaer Polytechnic Institute, 2013

Honors & Awards

  • 2021 National Science Foundation CAREER Award
  • 2020 Rita Schaffer Young Investigator Award
  • 2020 Young Innovator of Cellular and Molecular Bioengineering (BMES Society)
  • NIH National Institute of Biomedical Imaging and Bioengineering Trailblazer Award for New and Early Stage Investigators

Research Overview

bioelectric medicine, development of novel interventions and tissue engineered platforms for nerve regeneration and repair, body-on-a-chip for enteric-gut interactions

Advanced Biosystems for Neuroengineering Laboratory

Research in the Advanced Biosystems for Neuroengineering Laboratory (ABNEL) focuses on neural engineering and the interface between neurons and surrounding tissues. Specifically ABNEL develops novel and transformative devices, biomaterials, and biophysical-based therapies for this aims. Current work centers on the gut, heart, and central/peripheral nervous system.

Advanced Biosystems for Neuroengineering Lab

Selected Research Projects

Department Research Areas

Selected Publications

  • Bindas, Adam J., Kulkarni, Subhash, Koppes, Ryan A.Koppes, Abigail N. (2021). Parkinson’s Disease and the Gut: Models of an Emerging Relationship. Acta Biomaterialia, 10.1016/J.ACTBIO.2021.03.071
  • Diaz Vera, David, Soucy, Jonathan R., Lee, Audrey, Koppes, Ryan A., Koppes, Abigail N. (2021). Light irradiation of peripheral nerve cells: Wavelength impacts primary sensory neuron outgrowth in vitro. Journal of Photochemistry and Photobiology B: Biology, 215,112105. 10.1016/J.JPHOTOBIOL.2020.112105
  • Ventre, Daniel M., Cluff, Avery, Gagnon, Christian, Diaz Vera, David, Koppes, Ryan A., Koppes, Abigail N. (2021). The effects of low intensity focused ultrasonic stimulation on dorsal root ganglion neurons and Schwann cells in vitro. Journal of Neuroscience Research, 99(1),374-391. 10.1002/JNR.24700
  • S. Hosic, W. Lake, E. Stas, R. Koppes, D. Breault, S. Murthy, A. Koppes, Cholinergic Activation of Primary Human Derived Intestinal Epithelium does not Ameliorate TNF-α Induced Injury, Cellular and Molecular Bioengineering (Journal of BMES), CMBE 2020 Young Innovator Issue, 2020
  • S. Hosic, M. Puzan, F. Zhou, R. Koppes, D. Breault, S. Murthy, A. Koppes, Rapid Prototyping of a Multilayer Microphysiological System for Primary Human Intestinal Epithelial Culture, ACS Biomaterials Science & Engineering, 2020
  • K. Nichols, R. Koppes, A. Koppes, Recent Advancements in Microphysiological Systems for Neural Development and Disease, Invited Review; Current Opinion in Biomedical Engineering, 2020
  • M. Puzan, S. Hosic, C. Ghio, A.N. Koppes, Enteric Nervous System Regulation of Intestinal Stem Cell Differentiation and Epithelial Monolayer Function, Scientific Reports, 8(1), 2018, 6313
  • D. Ventre, M. Puzan, E. Ashbolt, A.N. Koppes Enhanced Total Neurite Outgrowth and Secondary Branching in Dorsal Root Ganglion Neurons Elicited by Low Intensity Pulsed Ultrasound, Journal of Neural Engineering, 15(4), 2018, 046013

Undergraduate

Oct 12, 2021

Fall 2021 PEAK Experiences Awardees

Congratulations to the COE student recipients of the Fall 2021 PEAK Experiences Awards. The PEAK Experiences Awards are a progressively structured sequence of opportunities designed to support learners as they continue climbing to new heights of achievement in undergraduate research and creative endeavor throughout their Northeastern journeys. ASCENT AWARDS Shana Broitman, COE’23, “Overcoming STING Silencing […]

David R. Dias Vera

Spotlight Story

Oct 01, 2021

PhD Spotlight: David R. Dias Vera, PhD’20 – Chemical Engineering

Advised by Abigail Koppes, Associate Professor of Chemical Engineering After receiving his bachelor’s degree in chemical engineering from the Universidad Autonoma de Santo Domingo in 2013, David R. Diaz Vera, PhD’20, chemical engineering, worked at Falconbridge Dominicana for almost two years before joining Northeastern University. As a PhD student in the Department of Chemical Engineering […]

Abigail Koppes

Faculty

Jul 16, 2021

Abigail Koppes Selected for 2021 NASA STAR Program

ChE Associate Professor Abigail Koppes was selected to be part of the highly competitive NASA’s Spaceflight Technologies, Application, and Research (STAR) Program for working with NASA and flight-ready experiment design.

Students

Jun 07, 2021

Summer 2021 PEAK Experiences Awardees

Congratulations to the COE student recipients of the Summer 2021 PEAK Experiences Awards. The PEAK Experiences Awards are a progressively structured sequence of opportunities designed to support learners as they continue climbing to new heights of achievement in undergraduate research and creative endeavor throughout their Northeastern journeys. BASE CAMP AWARDS Ana Salichs, E’22, “Colorimetric Assays […]

guohao dai, ryan koppes, & abigail koppes

Faculty

May 20, 2021

Improving Vein Grafts for Patients with Cardiovascular Diseases

BioE Associate Professor Guohao Dai (PI), ChE Assistant Professors Ryan Koppes (PI), and Abigail Koppes (co-PI) were awarded a $430K NIH grant from the National Institute of Neurological Disorders and Stroke for “Bioengineer a Humanized Autonomic Neurovascular Innervation on a Chip”.

portrait Abigail Koppes in her lab

Faculty

Apr 05, 2021

NSF CAREER Award to Understand How the Nervous System Regulates Gut Inflammation

Assistant Professor Abigail Koppes, chemical engineering, received a $500K NSF CAREER Award, titled “Defining the Regulators of Enteric Plasticity in Engineered Microfluidic Environments.” Her research focuses on developing new, non-invasive methods of exploring human cellular responses to biological signals. She and her team are developing plastic, disposable handheld devices that expose engineered tissue to a range of signals, then measure its response.

Students

Feb 08, 2021

Spring 2021 PEAK Experience Recipients

Congratulations to the COE student recipients of the Spring 2021 PEAK Experiences Awards. The PEAK Experiences Awards are a progressively structured sequence of opportunities designed to support learners as they continue climbing to new heights of achievement in undergraduate research and creative endeavor throughout their Northeastern journeys. PEAK Experience Ascent Awardees Ryan Brady, COE’22, Chemical […]

group photo of all award winners

Faculty

Oct 30, 2020

Abigail Koppes Receives the 2020 CMBE Young Innovator Award

ChE Assistant Professor Abigail Koppes received the 2020 Cellular and Molecular Bioengineering (CMBE) Young Innovator Award, in which CMBE publishes the most innovative and impactful bioengineering studies carried out by junior faculty in the field.

cover of Advanced BioSystems journal

Faculty

Sep 03, 2020

Abigail and Ryan Koppes Featured on Inside Front Cover of Advanced Biosystems

ChE Assistant Professors Abigail Koppes and Ryan Koppes’ research on “Reconfigurable Microphysiological Systems for Modeling Innervation and Multitissue Interactions” was published in the September issue of Advanced Biosystems.

male and female professor posing in their chemical engineering lab with microscope in background

Faculty

Aug 13, 2020

Abigail Koppes and Ryan Koppes Published in the Journal of Neuroscience Research

ChE Assistant Professors Abigail Koppes and Ryan Koppes published their research in the Journal of Neuroscience titled: “The effects of low intensity focused ultrasonic stimulation on dorsal root ganglion neurons and Schwann cells in vitro.”

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