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Abigail N. Koppes

Assistant Professor,  Chemical Engineering
Affiliated Faculty,  Bioengineering

Contact

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Office

  • 340 Mugar
  • 617.373.6221

Lab

  • 111 Mugar
  • 617.373.8161

Research Focus

bioelectric medicine, development of novel interventions and tissue engineered platforms for nerve regeneration and repair, body-on-a-chip for enteric-gut interactions

About

Joined the Chemical Engineering Department in Fall 2014.

The main focus of the Advanced Biomaterials for NeuroEngineering Laboratory (ABNEL) is advancing treatments for persons suffering from debilitating disorders and injuries of the central and peripheral nervous system. Using a combinatorial approach, we seek to create therapeutic strategies for improved nerve guidance channels that incorporate biomaterial manufacturing, biophysical (optogenetics) cues, structural (nanotopography) cues, and/or biochemical (cytokine) stimulation to modulate neuronal and non-neuronal support cell behavior. We are interested in probing the underlying mechanisms of neural growth and regeneration while engineering future modalities for neural tissue engineering applications.

Through tissue engineering of the enteric nervous system, the ‘Brain in the Gut,’ we hope to improve drug discovery platforms and regenerative medicine interventions for the millions of people suffering from disorders of the gastrointestinal tract, such as irritable bowel diseases. This work will combine primary small intestinal organoid culture with neuro-engineering techniques to recapitulate this complex biological system. Ultimately, we aim to understand the underlying mechanisms of cellular responses to engineered systems and their native biological niches towards rationally designed therapies. Our research utilizes techniques from bioengineering, chemical engineering, materials science, and cellular, molecular, and systems biology.

Education

  • B.S. (Biomedical Engineering) Rensselaer Polytechnic Institute, 2007
  • M.S. (Biomedical Engineering) Rensselaer Polytechnic Institute, 2010
  • PhD (Biomedical Engineering) Rensselaer Polytechnic Institute, 2013

Research Overview

bioelectric medicine, development of novel interventions and tissue engineered platforms for nerve regeneration and repair, body-on-a-chip for enteric-gut interactions

Selected Research Projects

  • Biomanufactured Nerve Guidance Channels for Complex Nerve Repair
    • Co-Principal Investigator, Northeastern University
  • GUMI: New in Vitro Platforms to Parse the Human Gut-Epithelial-Microbiome-Immune Axis
    • Principal Investigator, National Institutes of Health
  • Trailblazer: Engineering a Humanized Gut-Enteric-Axis
    • Principal Investigator, National Institutes of Health

Department Research Areas

Selected Publications

  • M.L. Puzan, B. Legesse, R.A. Koppes, H. Fenniri, A.N. Koppes, Bioactive Organic Rosette Nanotubes Support Sensory Neurite Outgrowth, ACS Biomaterials Science & Engineering, 4(5), 2018, 1630-1640
  • A.R. Spencer, A. Primbetova, A.N. Koppes, R.A. Koppes, H. Fenniri, N. Annabi, Electroconductive Gelatin Methacryloyl-PEDOT: PSS Composite Hydrogels: Design, Synthesis, and Properties, ACS Biomaterials Science & Engineering, 4(5), 2018, 1558-1567
  • M. Puzan, S. Hosic, C. Ghio, A.N. Koppes, Enteric Nervous System Regulation of Intestinal Stem Cell Differentiation and Epithelial Monolayer Function, Scientific Reports, 8(1), 2018, 6313
  • D. Ventre, M. Puzan, E. Ashbolt, A.N. Koppes, Enhanced Total Neurite Outgrowth and Secondary Branching in Dorsal Root Ganglion Neurons Elicited by Low Intensity Pulsed Ultrasound, Journal of Neural Engineering, 15(4), 2018, 046013
  • J.R. Soucy, E. Shirzaei Sani, R.P. Lara, D. Diaz, F. Dias, A.S. Weiss, A.N. Koppes, R.A. Koppes, N. Annabi, Photocrosslinkable Gelatin/Tropoelastin Hydrogel Adhesives for Peripheral Nerve Repair, Tissue Engineering Part A, 2018

Faculty

Feb 19, 2020

Observing How Cells Interact

ChE Assistant Professor Abigail Koppes is isolating individual cell types to identify how they interact with their environment.

Faculty

Jan 30, 2020

Translating the ‘Mastermind’ Concept from Business to Academia

Assistant Professors Danielle Levac (Bouvé), Emily Zimmerman (Bouvé), Kristen Allison (Bouvé), Abigail Koppes (ChE), Sarah Ostadabbas (ECE), Jessica Oakes (BioE), and Associate Professor Eno Ebong (ChE) were awarded a 2020 ADVANCE Mutual Mentoring Advancement Program (M2AP) Grant for “Translating the ‘Mastermind’ Concept from Business to Academia: Facilitating Peer mentorship among female PIs leading active research labs”.

guohao dai, ryan koppes, & abigail koppes

Faculty

Nov 12, 2019

AHA Grant to Explore the Innervation of Arterial Grafts

Associate Professor Guohao Dai from the Department of Bioengineering, Assistant Professor Ryan Koppes and Abigail Koppes from the Department of Chemical Engineering were awarded $200K from the American Heart Association (AHA) Innovative Project Award for “Bioengineer an autonomic neurovascular system to explore the innervation of arterial grafts”.

Faculty

Sep 13, 2019

Abby Koppes Featured as a Segment on an NPR WHYY The Pulse Episode

Chemical Engineering Assistant Professor Abby Koppes was featured as a segment on an NPR WHYY The Pulse Episode to discuss her research platform “guts on a chip.”

Undergraduate

Apr 01, 2019

Love of Science Leads to Prestigious Award

Minhal Ahmed, a fifth-year bioengineering student, was named the winner of the Harold D. Hodgkinson Achievement Award for 2019, one of the highest honors a senior can receive.

Faculty

Jan 03, 2019

Gut Health and Functional Foods Top Charts of 2019 Food Trends

ChE Assistant Professor Abigail Koppes was featured in the Forbes article "Gut Health and Functional Foods Top Charts of 2019 Food Trends".

Spotlight Story

Dec 12, 2018

Northeastern’s First Mitchell Scholar and More

Was recently one of only 12 students nationally selected as a George J. Mitchell Scholar. He is also a recipient of the prestigious Barry Goldwater Scholarship and the 2019 Harold D. Hodgkinson Achievement Award—one of the highest honors a senior can receive.

Faculty

Nov 27, 2018

Prof. Koppes at AIChE WIC

The AIChE Women’s Initiative Committee (WIC) hosted a full day symposium of female speakers at AIChE 2018 to highlight the significant contributions of women to the chemical engineering field, including ChE Assistant Professor Abby Koppes who presented on “Engineered Models of the Gut-Brain Axis”.

Graduate

Oct 09, 2018

COE NeuroArt Winner

MBF Bioscience recently selected ChE PhD student Danielle Large as a NeuroArt winner and her work was featured on the cover image of the November 2018 issue of the Journal of Neuroscience Research.

Faculty

Jun 15, 2018

Featured New PI – Abigail Koppes, Ph.D.

ChE Assistant Professor Abigail Koppes was nominated by the New PI community (new PI slack) of over 900 folks worldwide as “Featured new PI” for the month of June.

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