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Abigail N. Koppes

Assistant Professor,  Chemical Engineering
Affiliated Faculty,  Bioengineering

Contact

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Office

  • 340 Mugar
  • 617.373.6221

Lab

  • 111 Mugar
  • 617.373.8161

Research Focus

bioelectric medicine, development of novel interventions and tissue engineered platforms for nerve regeneration and repair, body-on-a-chip for enteric-gut interactions

About

Joined the Chemical Engineering Department in Fall 2014.

The main focus of the Advanced Biomaterials for NeuroEngineering Laboratory (ABNEL) is advancing treatments for persons suffering from debilitating disorders and injuries of the central and peripheral nervous system. Using a combinatorial approach, we seek to create therapeutic strategies for improved nerve guidance channels that incorporate biomaterial manufacturing, biophysical (optogenetics) cues, structural (nanotopography) cues, and/or biochemical (cytokine) stimulation to modulate neuronal and non-neuronal support cell behavior. We are interested in probing the underlying mechanisms of neural growth and regeneration while engineering future modalities for neural tissue engineering applications.

Through tissue engineering of the enteric nervous system, the ‘Brain in the Gut,’ we hope to improve drug discovery platforms and regenerative medicine interventions for the millions of people suffering from disorders of the gastrointestinal tract, such as irritable bowel diseases. This work will combine primary small intestinal organoid culture with neuro-engineering techniques to recapitulate this complex biological system. Ultimately, we aim to understand the underlying mechanisms of cellular responses to engineered systems and their native biological niches towards rationally designed therapies. Our research utilizes techniques from bioengineering, chemical engineering, materials science, and cellular, molecular, and systems biology.

Education

  • B.S. (Biomedical Engineering) Rensselaer Polytechnic Institute, 2007
  • M.S. (Biomedical Engineering) Rensselaer Polytechnic Institute, 2010
  • PhD (Biomedical Engineering) Rensselaer Polytechnic Institute, 2013

Research Overview

bioelectric medicine, development of novel interventions and tissue engineered platforms for nerve regeneration and repair, body-on-a-chip for enteric-gut interactions

Selected Research Projects

  • Biomanufactured Nerve Guidance Channels for Complex Nerve Repair
    • Co-Principal Investigator, Northeastern University
  • GUMI: New in Vitro Platforms to Parse the Human Gut-Epithelial-Microbiome-Immune Axis
    • Principal Investigator, National Institutes of Health
  • Trailblazer: Engineering a Humanized Gut-Enteric-Axis
    • Principal Investigator, National Institutes of Health

Department Research Areas

Selected Publications

  • M.L. Puzan, B. Legesse, R.A. Koppes, H. Fenniri, A.N. Koppes, Bioactive Organic Rosette Nanotubes Support Sensory Neurite Outgrowth, ACS Biomaterials Science & Engineering, 4(5), 2018, 1630-1640
  • A.R. Spencer, A. Primbetova, A.N. Koppes, R.A. Koppes, H. Fenniri, N. Annabi, Electroconductive Gelatin Methacryloyl-PEDOT: PSS Composite Hydrogels: Design, Synthesis, and Properties, ACS Biomaterials Science & Engineering, 4(5), 2018, 1558-1567
  • M. Puzan, S. Hosic, C. Ghio, A.N. Koppes, Enteric Nervous System Regulation of Intestinal Stem Cell Differentiation and Epithelial Monolayer Function, Scientific Reports, 8(1), 2018, 6313
  • D. Ventre, M. Puzan, E. Ashbolt, A.N. Koppes, Enhanced Total Neurite Outgrowth and Secondary Branching in Dorsal Root Ganglion Neurons Elicited by Low Intensity Pulsed Ultrasound, Journal of Neural Engineering, 15(4), 2018, 046013
  • J.R. Soucy, E. Shirzaei Sani, R.P. Lara, D. Diaz, F. Dias, A.S. Weiss, A.N. Koppes, R.A. Koppes, N. Annabi, Photocrosslinkable Gelatin/Tropoelastin Hydrogel Adhesives for Peripheral Nerve Repair, Tissue Engineering Part A, 2018

Faculty

Aug 13, 2020

Abigail Koppes and Ryan Koppes Published in the Journal of Neuroscience Research

ChE Assistant Professors Abigail Koppes and Ryan Koppes published their research in the Journal of Neuroscience titled: “The effects of low intensity focused ultrasonic stimulation on dorsal root ganglion neurons and Schwann cells in vitro.”

Faculty

Aug 03, 2020

Abigail Koppes Receives BMES Rita Schaffer Young Investigator Award

ChE Assistant Professor Abigail Koppes won the Rita Schaffer Young Investigator Award from the Biomedical Engineering Society.

Faculty

Jul 16, 2020

Cryopreservation of Cardiac Autonomic Neurons

ChE Assistant Professor Abigail Koppes and Assistant Professor Ryan Koppes’ research on “Cryopreservation and functional analysis of cardiac autonomic neurons” was published in the Journal of Neuroscience Methods.

Faculty

Jun 24, 2020

Investigating Intestinal Inflammation

ChE Assistant Professor Abigail Koppes and Assistant Professor Ryan Koppes’ research on “Cholinergic Activation of Primary Human Derived Intestinal Epithelium Does Not Ameliorate TNF-α Induced Injury” was published in the latest issue of Cellular and Molecular Bioengineering.

Faculty

Jun 05, 2020

Advancements in Microphysiological Systems

ChE Assistant Professor Abigail Koppes, Assistant Professor Ryan Koppes, and PhD Student Kyla Nichols’ research on “Recent advancements in microphysiological systems for neural development and disease” was published in the Current Opinion in Biomedical Engineering.

In the Media

May 29, 2020

Why I paused my Ph.D. research to work as an industry intern

ChE PhD student Tess Torregrosa wrote an editorial in Science Magazine on “Why I paused my Ph.D. research to work as an industry intern“, Tess was co-advised by Assistant Professors Ryan Koppes and Abigail Koppes.

Faculty

May 21, 2020

Rapid Prototyping of Multilayer Microphysiological Systems

ChE Assistant Professor Ryan Koppes, Assistant Professor Abigail Koppes, and PhD students were published in ACS Biomaterials Science & Engineering for their research on “Rapid Prototyping of Multilayer Microphysiological Systems”. Abstract Source: ACS Microfluidic organs-on-chips aim to realize more biorelevant in vitro experiments compared to traditional two-dimensional (2D) static cell culture. Often such devices are […]

Faculty

Feb 19, 2020

Observing How Cells Interact

ChE Assistant Professor Abigail Koppes is isolating individual cell types to identify how they interact with their environment.

Faculty

Feb 05, 2020

Materials and Microenvironments for Engineering the Intestinal Epithelium

ChE Professor & Associate Chair of Research Rebecca Carrier, Assistant Professor Abigail Koppes, and Assistant Professor Ryan Koppes research on “Materials and Microenvironments for Engineering the Intestinal Epithelium” was published in the Annals of Biomedical Engineering. Abstract Source: Springer The barrier functions of the gastrointestinal tract rely in large part on a single layer of […]

Faculty

Jan 30, 2020

Translating the ‘Mastermind’ Concept from Business to Academia

Assistant Professors Danielle Levac (Bouvé), Emily Zimmerman (Bouvé), Kristen Allison (Bouvé), Abigail Koppes (ChE), Sarah Ostadabbas (ECE), Jessica Oakes (BioE), and Associate Professor Eno Ebong (ChE) were awarded a 2020 ADVANCE Mutual Mentoring Advancement Program (M2AP) Grant for “Translating the ‘Mastermind’ Concept from Business to Academia: Facilitating Peer mentorship among female PIs leading active research labs”.

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