Mark Niedre

Professor and Associate Chair For Research,  Bioengineering

Contact

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Office

  • 217 ISEC
  • 617.373.5410

Research Focus

Biomedical optics and non-invasive imaging, rare cell detection and tracking in the body, ultrafast time-domain diffuse optical imaging, image reconstruction and biomedical signal processing

About

Post-Doctoral Fellowship: Harvard Medical School and Massachusetts General Hospital, 2005-2008 Ph.D., Medical Biophysics, University of Toronto, 2005 B.Eng., Engineering Physics, McMaster University, 1998

Education

  • PhD, University of Toronto, 2004

Honors & Awards

  • 2015 COE Faculty Fellow
  • 2015 Søren Buus Outstanding Research Award
  • Massachusetts Life Sciences Center New Investigator Award

Research Overview

Biomedical optics and non-invasive imaging, rare cell detection and tracking in the body, ultrafast time-domain diffuse optical imaging, image reconstruction and biomedical signal processing

Biomedical Optics Research Group

Our group studies the application of optical engineering to biomedicine. By nature the field is highly inter-disciplinary and requires the integration of diverse backgrounds such as optical design, software and hardware engineering, image reconstruction, biology, chemistry, and medicine.
Biomedical Optics Research Group

Selected Research Projects

Selected Publications

  • R. Patil, M. Srinivasarao, M. Amiji, P.S. Low, M. Niedre Fluorescence Labeling of Circulating Tumor Cells with a Folate Receptor-Targeted Molecular Probe for Diffuse In Vivo Flow Cytometry, Molecular Imaging and Biology, 2020
  • W. Di, X. Tan, I.A.C. Calderon, A.E. Reilly, M. Niedre, H.A. Clark, Real-time Particle-By-Particle Detection of Erythrocyte- Camouflaged Microsensor With Extended Circulation Time in the Bloodstream, Proceedings of the National Academy of Sciences USA, 11(7), 2020, 3509-3517
  • X. Tan, R. Patil, P. Bartosik, J. Runnels, C.P. Lin, M. Niedre Ultra-Rare In Vivo Flow Cytometry, Scientific Reports, 9(1), 2019, 3366
  • V. Pera, X. Tan, J. Runnels, N. Sardesai, C.P. Lin, M. Niedre Diffuse Fluorescence Fiber Probe for In Vivo Detection of Circulating Cells, Journal of Biomedical Optics, 22(3), 2017, 037004
  • C. Hartmann, R. Patil, C.P. Lin, M. Niedre Fluorescence Detection, Enumeration and Characterization of Single Circulating Cells In Vivo: Technology, Applications and Future Prospects, Physics in Medicine and Biology, 63 (1), 2017, 01TR01
  • Y. Mu, V. Pera, M. Niedre, Multiplexed Fluorescence Mediated Tomography with Temporal and Spectral Data, Journal of Biomedical Optics, 21(10), 2016, 105001
Mark Niedre and Chiara Bellini

Faculty

Mar 07, 2022

Research to Help Unlock the Mystery of How Cancer Spreads

Bioengineering Professor Mark Niedre and Assistant Professor Chiara Bellini received a 5-year, $2.7M grant titled “Continuous, Non-Invasive Optical Monitoring of Circulating Tumor Cell-Mediated Metastasis in Awake Mice” from the National Cancer Institute and National Institutes of Health. The project will develop a new instrument (“w-DiFC”) for optically detecting and counting rare circulating tumor cells continuously and non-invasively in awake, freely-moving mice.

professor working in lab on project

Faculty

Feb 12, 2021

Developing Technology to Optimally Detect and Count Circulating Tumor Cells without Drawing Blood

BioE Professor Mark Niedre and Bouve/ChE Professor Mansoor Amiji are using their recent NCI/NIH grant to detect circulating tumor cells in the blood.

Mark Niedre and Mansoor Amiji

Faculty

Jan 07, 2021

Niedre and Amiji Receive National Cancer Institute Award

Bioengineering Professor and Associate Chair Mark Niedre and Bouve/ChE Distinguished Professor Mansoor Amiji received a 2-year, $400K grant titled “Fluorescence Molecular In Vivo Liquid Biopsy of Circulating Tumor Cells” from the National Cancer Institute and National Institutes of Health.

alumna works in the lab at her job working on a mechanical hand

Students

Dec 02, 2020

Finding Her Path

In sports, they say, “You miss 100% of the shots you don’t take.” Roshani A. Patil, ME’19, bioengineering, took that statement to heart when she decided to get a graduate degree.

Faculty

May 17, 2018

Niedre Awarded Patent

BioE Associate Professor Mark Niedre and ECE alum Eric Zettergren, ME’11, were awarded a patent for “Systems and methods for sensing, enumerating and imaging rare cells with diffuse light”.

Faculty

Feb 06, 2018

Bioengineering Professors Clark and Niedre Awarded a 4 year, $1.4 Million Grant from the NIH

Bioengineering Professor Heather Clark and Associate Professor Mark Niedre awarded a $1.4M, 4-year NIH grant to develop circulating red blood cell based nanosensors for non-invasive optical drug monitoring.

Faculty

Mar 23, 2017

FY18 TIER 1 Award Recipients

21 COE faculty and affiliates were recipients of FY18 TIER 1 Interdisciplinary Research Seed Grants for 12 different projects representing $600K dollars of investment in research.

Mar 22, 2016

FY17 TIER 1 Award Recipients

23 COE faculty and affiliates were recipients of FY17 TIER 1 Interdisciplinary Research Seed Grants for 12 different projects representing over $600K dollars of investment in research.

Aug 26, 2015

Niedre Awarded $1.5M Grant

ECE Associate Professor, Mark Niedre, received a $1.5M RO1 grant from the National Heart Lung and Blood Institute of NIH for Ultra-Rare Cell In Vivo Flow Cytometry.

May 07, 2015

2015 COE Faculty Fellows

Congratulations to this year’s class of COE Faculty Fellows: Yunsi Fei, Auroop Ganguly, Mark Niedre, and Ashkan Vaziri.

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