Mark Niedre
Professor and Associate Chair For Research,
Bioengineering
Office
- 217 ISEC
- 617.373.5410
Research Focus
Biomedical optics and non-invasive imaging, rare cell detection and tracking in the body, ultrafast time-domain diffuse optical imaging, image reconstruction and biomedical signal processing
About
Post-Doctoral Fellowship: Harvard Medical School and Massachusetts General Hospital, 2005-2008 Ph.D., Medical Biophysics, University of Toronto, 2005 B.Eng., Engineering Physics, McMaster University, 1998
Education
- PhD, University of Toronto, 2004
Honors & Awards
- 2015 COE Faculty Fellow
- 2015 Søren Buus Outstanding Research Award
- Massachusetts Life Sciences Center New Investigator Award
Research Overview
Biomedical optics and non-invasive imaging, rare cell detection and tracking in the body, ultrafast time-domain diffuse optical imaging, image reconstruction and biomedical signal processing
Biomedical Optics Research Group
Selected Research Projects
- Continuous, Non-Invasive Optical Monitoring of Circulating Tumor Cell-Mediated Metastasis in Awake Mice
- – Principal Investigator, National Cancer Insititute and NIH
- Fluorescence Molecular In Vivo Liquid Biopsy of Circulating Tumor Cells
- – Principal Investigator, National Institutes of Health
- High Resolution Multiplexed Fluorescence Tomography
- – Principal Investigator, National Institutes of Health
- Ultra-Rare Cell In Vivo Flow Cytometry
- – Principal Investigator, National Institutes of Health
Department Research Areas
Selected Publications
- R. Patil, M. Srinivasarao, M. Amiji, P.S. Low, M. Niedre Fluorescence Labeling of Circulating Tumor Cells with a Folate Receptor-Targeted Molecular Probe for Diffuse In Vivo Flow Cytometry, Molecular Imaging and Biology, 2020
- W. Di, X. Tan, I.A.C. Calderon, A.E. Reilly, M. Niedre, H.A. Clark, Real-time Particle-By-Particle Detection of Erythrocyte- Camouflaged Microsensor With Extended Circulation Time in the Bloodstream, Proceedings of the National Academy of Sciences USA, 11(7), 2020, 3509-3517
- X. Tan, R. Patil, P. Bartosik, J. Runnels, C.P. Lin, M. Niedre Ultra-Rare In Vivo Flow Cytometry, Scientific Reports, 9(1), 2019, 3366
- V. Pera, X. Tan, J. Runnels, N. Sardesai, C.P. Lin, M. Niedre Diffuse Fluorescence Fiber Probe for In Vivo Detection of Circulating Cells, Journal of Biomedical Optics, 22(3), 2017, 037004
- C. Hartmann, R. Patil, C.P. Lin, M. Niedre Fluorescence Detection, Enumeration and Characterization of Single Circulating Cells In Vivo: Technology, Applications and Future Prospects, Physics in Medicine and Biology, 63 (1), 2017, 01TR01
- Y. Mu, V. Pera, M. Niedre, Multiplexed Fluorescence Mediated Tomography with Temporal and Spectral Data, Journal of Biomedical Optics, 21(10), 2016, 105001
Mar 07, 2022
Research to Help Unlock the Mystery of How Cancer Spreads
Bioengineering Professor Mark Niedre and Assistant Professor Chiara Bellini received a 5-year, $2.7M grant titled “Continuous, Non-Invasive Optical Monitoring of Circulating Tumor Cell-Mediated Metastasis in Awake Mice” from the National Cancer Institute and National Institutes of Health. The project will develop a new instrument (“w-DiFC”) for optically detecting and counting rare circulating tumor cells continuously and non-invasively in awake, freely-moving mice.
Feb 12, 2021
Developing Technology to Optimally Detect and Count Circulating Tumor Cells without Drawing Blood
BioE Professor Mark Niedre and Bouve/ChE Professor Mansoor Amiji are using their recent NCI/NIH grant to detect circulating tumor cells in the blood.
Jan 07, 2021
Niedre and Amiji Receive National Cancer Institute Award
Bioengineering Professor and Associate Chair Mark Niedre and Bouve/ChE Distinguished Professor Mansoor Amiji received a 2-year, $400K grant titled “Fluorescence Molecular In Vivo Liquid Biopsy of Circulating Tumor Cells” from the National Cancer Institute and National Institutes of Health.
Dec 02, 2020
Finding Her Path
In sports, they say, “You miss 100% of the shots you don’t take.” Roshani A. Patil, ME’19, bioengineering, took that statement to heart when she decided to get a graduate degree.
May 17, 2018
Niedre Awarded Patent
BioE Associate Professor Mark Niedre and ECE alum Eric Zettergren, ME’11, were awarded a patent for “Systems and methods for sensing, enumerating and imaging rare cells with diffuse light”.
Feb 06, 2018
Bioengineering Professors Clark and Niedre Awarded a 4 year, $1.4 Million Grant from the NIH
Bioengineering Professor Heather Clark and Associate Professor Mark Niedre awarded a $1.4M, 4-year NIH grant to develop circulating red blood cell based nanosensors for non-invasive optical drug monitoring.
Mar 23, 2017
FY18 TIER 1 Award Recipients
21 COE faculty and affiliates were recipients of FY18 TIER 1 Interdisciplinary Research Seed Grants for 12 different projects representing $600K dollars of investment in research.
Mar 22, 2016
FY17 TIER 1 Award Recipients
23 COE faculty and affiliates were recipients of FY17 TIER 1 Interdisciplinary Research Seed Grants for 12 different projects representing over $600K dollars of investment in research.
Aug 26, 2015
Niedre Awarded $1.5M Grant
ECE Associate Professor, Mark Niedre, received a $1.5M RO1 grant from the National Heart Lung and Blood Institute of NIH for Ultra-Rare Cell In Vivo Flow Cytometry.
May 07, 2015
2015 COE Faculty Fellows
Congratulations to this year’s class of COE Faculty Fellows: Yunsi Fei, Auroop Ganguly, Mark Niedre, and Ashkan Vaziri.