Srinivas Sridhar

Affiliated Faculty,  Bioengineering
Affiliated Faculty,  Chemical Engineering
University Distinguished Professor,  Physics

Contact

Office

  • 210 DA
  • 617.373.2930

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Research Focus

nanomedicine; neurotechnology; drug delivery, MRI imaging

About

Srinivas Sridhar, Ph.D. is University Distinguished Professor of Physics, Biomedical Engineering and Chemical Engineering at Northeastern University, and Lecturer on Radiation Oncology, Harvard Medical School. He previously served as Vice Provost for Research at Northeastern University, overseeing the University’s research portfolio.

An elected Fellow of the American Physical Society, Sridhar’s current areas of research are nanomedicine, neurotechnology and MRI imaging.  His paper in Nature in 2003 was listed among Breakthroughs of 2003 by the journal Science. He has published more than 200 articles on nanomedicine, neurotechnology, nanophotonics, metamaterials, quantum chaos, superconductivity and collective excitations in materials.

As Founding Director of the Nanomedicine Innovation Center at Northeastern University, Sridhar established a Nanomedicine Center for synthesis and characterization of nanoparticle formulations. His team has prepared and characterized several nanoplatforms ranging from lipid, polymeric and metallic nanoparticles to implants for sustained release for drug delivery of chemotherapeutics and biologics such as PARP inhibitors and siRNA, for application in cancer, cardiovascular and neurological diseases. With his students he has developed a groundbreaking approach to quantitative MRI that is soon to be tested in patients. An entrepreneur, he has founded companies that are translating his discoveries to the clinic.

Sridhar is passionately committed to training future scientists and engineers and providing access to knowledge to all particularly to those from under-represented minority communities. He has trained more than 120 faculty, postdoctoral fellows, scientists, and graduate and undergraduate students. He is Director of the Nanomedicine Academy funded by grants for NSF and NIH, whose vision is to providing training in nanomedicine nationally and globally.  He is Director of CaNCURE: Cancer Nanomedicine Coops for Undergraduate Research, an NIH R25 program to provide research training in cancer nanomedicine. He is Director and PI of the NSF IGERT Nanomedicine Science and Technology Center. He developed several first-of-their kind courses in Nanomedicine. These unique programs have taught hundreds of graduate and undergraduate students in several minority serving institutions, and led to institutional change in the form of new programs in nanomedicine. Sridhar’s contributions to education and training have been recognized by awards and invitations to speak and to participate in national panels on education.

For more information visit cancurecancer.orgwww.northeastern.edu/igert, srinivassridhar.com.

Honors & Awards

  • Biomedical Engineering Diversity Award 2016
  • University Distinguished Professorship

Research Overview

nanomedicine; neurotechnology; drug delivery, MRI imaging

Selected Research Projects

  • CaNCURE: Cancer Nanomedicine Co-ops for Undergraduate Research Experiences
    • Principal Investigator, National Institutes of Health
  • Nanoformulations and Sustained Delivery of PARP Inhibitors for Breast Cancer
    • Principal Investigator, Department of Defense
  • Nanomedicine Academy of Minority Serving Institutions
    • Principal Investigator, National Science Foundation Development
  • Nanoscale Magnetism of Novel Structures
    • Principal Investigator, Air Force Research Laboratory
  • Neuro-Optical Diagnostic System for Macular Degeneration
    • Principal Investigator, National Institutes of Health
  • Quantitative Non-Invasive Brain Imaging using Magnetic Nanoparticles
    • Principal Investigator, National Institutes of Health

Selected Publications

  • Zhang D., Singh B., Moerland J., Mitchell O., Lockwood L., Carapellucci S., Sridhar S., and Liby K.T. (2021). Sustained, Local Delivery of the PARP Inhibitor Talazoparib Prevents the Development of Mammary Gland Hyperplasia in Brca1-deficient Mice. Sci Rep, 11(1):1234. 10.1038/s41598-020-79663-7
  • Yang S., Wallach M., Krishna A., Kurmasheva R., and Sridhar S. (2021). Recent Developments in Nanomedicine for Pediatric Cancer. J Clin Med, 10(7):1437. 10.3390/jcm10071437
  • Rodell C.B., Baldwin P., Fernandez B., Weissleder R., Sridhar S., Dubach J.M. (2021). Quantification of Cellular Drug Biodistribution Addresses Challenges in Evaluating in vitro and in vivo Encapsulated Drug Delivery. Adv Ther (Weinh), 4(3):2000125. 10.1002/adtp.202000125
  • Versek C., Banijamali S.M.A., Bex P., Lashkari K., Kamarthi S., and Sridhar S. (2021). Portable Diagnostic System for Age-Related Macular Degeneration Screening Using Visual Evoked Potentials. Eye Brain. 13:111-127. 10.2147/EB.S295745
  • Timms L., Zhou T., Lyu Y., Qiao J., Mishra V., Lahoud R.M., Jayaraman G.V., Allegretti A.S., Drew D., Seethamraju R.T., Harisinghani M., and Sridhar S. (2021). Ferumoxytol-enhanced Ultrashort TE MRA and Quantitative Morphometry of the Human Kidney Vasculature. Abdom Radiol (NY). 10.1007/s00261-021-02984-2. Online ahead of print.
  • Singh B., Yang S., Krishna A., and Sridhar S. (2020). Nanoparticle Formulations of Poly (ADP-ribose) Polymerase Inhibitors for Cancer Therapy. Front Chem.8:594619. 10.3389/fchem.2020.594619
  • D. Zhang, P. Baldwin, A.S. Leal, S. Carapellucci, S. Sridhar, K.T. Liby, A Nano-Liposome Formulation of the Parp Inhibitor Talazoparib Enhances Treatment Efficacy and Modulates Immune Cell Populations in Mammary Tumors of BRCA- Deficient Mice, Theranostics, 9(21), 2019, 6224-6238
  • J. Qiao, X. Cai, Q. Xiao, Z. Chen, P. Kulkarni, C. Ferris, S. Kamarthi, S. Sridhar, Data on MRI brain Lesion Segmentation using K-means and Gaussian Mixture Model-Expectation Maximization, Data Brief, 27, 2019, 104628
  • P. Baldwin, A.W. Ohman, J.E. Medina, E.T. McCarthy, D.M. Dinulescu, S. Sridhar, Nanoformulation of Talazoparib Delays Tumor Progression and Ascites Formation in a Late Stage Cancer Model, Frontiers in Oncology, 9(353), 2019

Alumni

May 22, 2024

Bioengineering Alum and Diagnostics Company Co-Founder Sees Promise in New MRI Technology

Codi Gharagouzloo, PhD’16, bioengineering, started his pursuit of a cure for cancer as a research assistant for BioE and ChE Affiliated Professor Srinivas Sridhar. With support from BioE Affiliated Professor Craig Ferris, Gharagouzloo was able to co-found his own company and determine possible applications for the new QUTE-CE MRI technology.

Undergraduate

May 08, 2024

2024 URF Scholars Recipients

Thirty-six engineering students received 2024 URF Scholars Awards from Northeastern’s Office of Undergraduate Research and Fellowships. URF Scholars are students who are graduating this year and who have earned a PEAK Experience Award, applied for a distinguished fellowship, or participated in graduate school advising.

Spotlight Story

Feb 23, 2024

Exploring a Wealth of Options To Pursue Unique Educational Paths

Julia Treese, E’24, chemical engineering, started her Northeastern journey in the Explore program. After three co-ops and a variety of extracurriculars, she has found that biotech is her calling.

Faculty

Dec 07, 2023

2023 Stanford University Annual Assessment of Author Citations

The following COE professors are among the top scientists worldwide selected by Stanford University representing the top 2% of the most-cited scientists with single-year impact in various disciplines. The selection is based on the top 100,000 by c-score (with and without self-citations) or a percentile rank of 2% or above. The list below includes those […]

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Students

Apr 19, 2022

Congratulations RISE: 2022 Winners

Congratulations to our engineering students who won awards at the RISE:2022 Research, Innovation and Scholarship Expo!

Oct 17, 2016

Professor Srinivas Sridhar Receives Three New Grants

Congratulations to COS Professor (BioE & ChE Affiliated Professor) Srinivas Sridhar who has recently received three new grants totaling $1.13M. 1. Quantitative Neurovascular Imaging for Drug Abuse Research (NIH/NIDA grant). The Sridhar group has developed a new ground-breaking technique QUTE-CE MRI that leads to quantitative MRI imaging with unprecedented clarity and definition using magnetic nanoparticles. […]

Student Groups

Jul 14, 2016

Professor Srinivas Sridhar Receives 2016 BMES Diversity Award

The Awards Committee of the Biomedical Engineering Society (BMES) Board of Directors has selected Professor Srinivas Sridhar from the College of Science and Chemical Engineering as the recipient of the 2016 BMES Diversity Award. “We are very fortunate to have Prof. Sri Sridhar affiliated with chemical engineering due to his tireless efforts promoting diversity at […]

Mar 22, 2016

FY17 TIER 1 Award Recipients

23 COE faculty and affiliates were recipients of FY17 TIER 1 Interdisciplinary Research Seed Grants for 12 different projects representing over $600K dollars of investment in research.

Jan 04, 2016

NU Launches Nanomedicine Academy

ChE Professor & Chair Thomas Webster and COS Professor Srinivas Sridhar created the Nanomed­i­cine Academy of Minority Serving Institutions to broadcast graduate courses in nanomedicine to host universities.

Sep 29, 2015

Nanomedicine Academy for Minorities

COS Professor Srinivas Sridhar and ChE Professor & Chair Thomas Webster were awarded a $496K NSF grant to develop a "Nanomedicine Academy of Minority Serving Institutions".

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