cell and tissue engineering, quantitative principles of cancer cell biology and developmental biology
The Asthagiri lab elucidates design principles for engineering living cells and tissues. These design principles provide a foundation for tissue engineering and regenerative medicine. The implications extend beyond engineering artificial organ replacements. Synthetic multicellular structures that mimic their natural counterparts provide better platforms for drug discovery and screening. In addition, elucidating how multicellular structures assemble provides deeper insights into how these structures fall apart in diseases, such as cancer. Understanding the disassembly of multicellular structures sheds new insights into cancer development and helps to identify therapeutic strategies to re-shape diseased tissue.
- B.S. with distinction (Chemical Engineering) Cornell University, 1995
- Ph.D. (Chemical Engineering) Massachusetts Institute of Technology, 2000
- Postdoctoral Fellow Harvard Medical School, 2000-2001
- D.F. Milano, R.J. Natividad, Y. Saito, C.Y. Luo, S.K. Muthuswamy, A.R. Asthagiri, Positive Quantitative Relationship Between EMT and Contact-Initiated Sliding on Fiber-Like Tracks, Biophysical Journal, 111(7), 2016, 1569-1574
- D.F. Milano, N.A. Ngai, S.K. Muthuswamy, A.R. Asthagiri, Regulators of Metastasis Modulate the Migratory Response to Cell Contact Under Spatial Confinement, Biophysical Journal, 110(8), 2016, 1886-1895
- D.I. Walsh III, M.L. Lalli, J.M. Kassas, A.R. Asthagiri, S.K. Murthy, Cell Chemotaxis on Paper for Diagnostics, Analytical Chemistry, 87(11), 2015, 5505-5510
- M.L. Lalli, A.R. Asthagiri, Collective Migration Exhibits Greater Sensitivity but Slower Dynamics of Alignment to Applied Electric Fields, Cellular and Molecular Bioengineering, 8(2), 2015, 247-257
- K. Blogovic, E.S. Gong, D. F. Milano, R.J. Natividad, A.R. Asthagiri, Engineering Cell-Cell Signaling, Current Opinion in Biotechnology, 24(5), 2013, 940-947
- K. Kushiro, A.R. Asthagiri, Modular Design of Micropattern Geometry Achieves Combinatorial Enhancements in Cell Motility, Langmuir, 28(9), 2012, 4357-4362
- J.H. Kim, A.R. Asthagiri, Matrix Stiffening Sensitizes Epithelial Cells to EGF and Enables the Loss of Contact Inhibition of Proliferation, Journal of Cell Science, 124, 2011, 1280-1287
- J.H. Kim, L.J. Dooling, A.R. Asthagiri, Intercellular Mechanotransduction During Multicellular Morphodynamics, Royal Society Interface, 7(3), 2010, 341-350
- C.A. Giurumescu, P.W. Sternberg, A.R. Asthagiri, Predicting Phenotypic Diversity and the Underlying Quantitative Molecular Transitions, PLoS Computational Biology, 5(4), 2009, 1-13
- J.H. Kim, K. Kushiro, N.A. Graham, A.R. Asthagiri, Turnable Interplay Between Epidermal Growth Factor and Cell-Cell Contact Governs the Spatial Dynamics of Epithelial Growth, Proceedings of the National Academy of Sciences USA, 106(27), 2009, 11149-11153
Apr 28, 2016
BioE Associate Professor Anand Asthagiri explores the biophysics behind the spread of breast cancer, providing hope for future treatments and early diagnosis. Source: News @ Northeastern Metastasis. The very word evokes fear. Defined as the spread of cancer cells from one part of the body to another, metastasis is the cause of approximately 90 percent […]
Feb 17, 2016
Mark Lalli was honored with the 2015 Graduate Seminar Award. Lalli is a 4th year PhD student in Chemical Engineering under guidance of Anand Asthagiri. The winning seminar was titled "Impact of E-cadherin expression on highly confined electrotaxis." The Graduate Seminar Award gives $1500 to a recipient for traveling to a conference of their choice […]
May 26, 2015
Bioengineering PhD student David Walsh's research on "Cell Chemotaxis on Paper for Diagnostics" was recently published in Analytical Chemistry.
May 11, 2015
Recent ChE Alumni Alexander Colville reflects back on his NU career where he helped create the Bioengineering department and Biomedical Engineering Society, participated in an exchange program, and most importantly learned to apply his classroom problem solving skills to real world scenarios.
Apr 04, 2012
27 COE faculty and affiliates were recipients of FY13 TIER 1 Interdisciplinary Research Seed Grants for 21 different research projects.
Apr 04, 2012
ChE Associate Professor Anand Asthagiri was featured in the Biophysical Journal for his work in determining the effect of growth factors on cell-cell adhesion.
Mar 14, 2012
ChE Associate Professor Anand Asthagiri is developing "traffic patterns" to enhance the directionality and speed of a cell’s movement in the body to promote faster healing.
Feb 16, 2012
ChE Associate Professor Anand Asthagiri is featured in the journal Langmuir for showing how changing the geometry of a cell can enhance the cell’s motility.
Jan 01, 2011
Associate ProfessorThe Department of Chemical Engineering welcomed Dr. Anand Asthagiri in January 2011 as an associate professor. Dr. Asthagiri was attracted to Northeastern's plans for dynamic growth, the collegiality of the faculty and students and faculty scientific interaction. He believes that the work being done at Northeastern, from the students up to the administration, has […]