Erin J. Cram
Affiliated Faculty, Bioengineering
Professor, Biology
Associate Dean for Research, College of Science
Contact
- e.cram@northeastern.edu
- 424 Mugar Life Sciences
360 Huntington Ave
Boston, MA 02115
Office
- 617.373.7533
Related Links
Research Focus
Cell migration and mechanotransduction in C. elegans, improving production of drug compounds by medicinal plants
Education
- Ph.D., University of California, Berkeley, 2000
- B.S., University of North Carolina, Chapel Hill
Research Overview
Cell migration and mechanotransduction in C. elegans, improving production of drug compounds by medicinal plants
Selected Research Projects
- PlantSynBio: A Novel CRISPR SynBio Tool for Investigating and Reprogramming the Regulation of Alkaloid Biosynthesis in Catharanthus roseus
- – Co-Principal Investigator, National Science Foundation
- Elucidating the Role of ERM Proteins in Cytoskeletal Orientation in a Contractile Tissue
- – Principal Investigator, National Science Foundation
- In Vivo Analysis of Mechanotransduction
- – Principal Investigator, National Institutes of Health
- Zinc Finger Transcription Factors: Regulators of Growth, Development, and Alkaloid Biosynthesis
- – Co-Principal Investigator, National Science Foundation
Research Centers and Institutes
Selected Publications
- Kelley CA, Triplett O, Mallick S, Burkewitz K, Mair WB, Cram EJ. (2020) FLN-1/filamin is required to anchor the actomyosin cytoskeleton and for global organization of sub-cellular organelles in a contractile tissue. Cytoskeleton (Hoboken). 2020 Oct;77(10):379-398. doi: 10.1002/cm.21633.
- Castaneda PG, Cecchetelli AD, Pettit HN, Cram EJ. (2020) Gα/GSA-1 works upstream of PKA/KIN-1 to regulate calcium signaling and contractility in the Caenorhabditis elegans spermatheca. PLoS Genet. 2020 Aug 10;16(8):e1008644. doi: 10.1371/journal.pgen.1008644.
- C.A. Kelley, S. De Henau, L. Bell, T.B. Dansen, E.J. Cram Redox signaling modulates Rho activity and tissue contractility in the C. elegans spermatheca, Molecular Biology of the Cell, 2020, May 6
- S. Mortensen, D. Bernal-Franco, L.F. Cole, S. Sathitloetsakun, E.J. Cram, C.W.T. Lee-Parsons, EASI Transformation: An Efficient Transient Expression Method for Analyzing Gene Function in Catharanthus Roseus Seedlings, Frontiers in Plant Science, 10, 2019, 755
- J. Bouffard, A.D. Cecchetelli, C. Clifford, K. Sethi, R. Zaidel-Bar, E.J. Cram, The RhoGAP SPV-1 Regulates Calcium Signaling to Control the Contractility of the Caenorhabditis Elegans Spermatheca during Embryo Transits, Molecular Biology of the Cell, 30(7), 2019, 907-922
![Carolyn Lee-Parsons and Erin Cram](https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_600,h_400/https://coe.northeastern.edu/wp-content/uploads/news/che/lee-parsons-cram.jpg)
Mar 03, 2021
Investigating the Defense-Related Responses of Plants
ChE/COS Associate Professor Carolyn Lee-Parsons and BioE Affiliated Faculty member Erin Cram were awarded an $800K NSF grant for creating ” A Novel CRISPR SynBio Tool for Investigating and Reprogramming the Regulation of Alkaloid Biosynthesis in Catharanthus roseus.”
![Harikrishnan Parameswaran](https://sp-ao.shortpixel.ai/client/to_webp,q_glossy,ret_img,w_600,h_400/https://coe.northeastern.edu/wp-content/uploads/profiles/bioe/parameswaran-h-rect.png)
Aug 17, 2020
Research on Extracellular Matrix Making Waves for Asthma Therapy
BioE Assistant Professor Harikrishnan Parameswaran’s research on “Intercellular communication controls agonist-induced calcium oscillations independently of gap junctions in smooth muscle cells” was published in Science Advances.
Apr 09, 2019
FY20 TIER 1 Award Recipients
25 COE faculty and affiliates were recipients of FY20 TIER 1 Interdisciplinary Research Seed Grants for 18 different projects representing up to $900K dollars of investment in research.
Mar 22, 2016
FY17 TIER 1 Award Recipients
23 COE faculty and affiliates were recipients of FY17 TIER 1 Interdisciplinary Research Seed Grants for 12 different projects representing over $600K dollars of investment in research.
Apr 04, 2012
FY13 TIER 1 Award Recipients
27 COE faculty and affiliates were recipients of FY13 TIER 1 Interdisciplinary Research Seed Grants for 21 different research projects.