Erin J. Cram

Affiliated Faculty,  Bioengineering
Professor,  Biology

Contact

Office

  • 617.373.7533

Research Focus

Cell migration and mechanotransduction in C. elegans, improving production of drug compounds by medicinal plants

Education

  • Ph.D., University of California, Berkeley, 2000
  • B.S., University of North Carolina, Chapel Hill

Research Overview

Cell migration and mechanotransduction in C. elegans, improving production of drug compounds by medicinal plants

Selected Research Projects

  • Elucidating the Role of ERM Proteins in Cytoskeletal Orientation in a Contractile Tissue
    • – Principal Investigator, National Science Foundation
  • In Vivo Analysis of Mechanotransduction
    • – Principal Investigator, National Institutes of Health
  • Zinc Finger Transcription Factors: Regulators of Growth, Development, and Alkaloid Biosynthesis
    • – Co-Principal Investigator, National Science Foundation

College Research Initiatives

Selected Publications

  • C.A. Kelley, S. De Henau, L. Bell, T.B. Dansen, E.J. Cram Redox signaling modulates Rho activity and tissue contractility in the C. elegans spermatheca, Molecular Biology of the Cell, 2020, May 6
  • S. Mortensen, D. Bernal-Franco, L.F. Cole, S. Sathitloetsakun, E.J. Cram, C.W.T. Lee-Parsons, EASI Transformation: An Efficient Transient Expression Method for Analyzing Gene Function in Catharanthus Roseus Seedlings, Frontiers in Plant Science, 10, 2019, 755
  • J. Bouffard, A.D. Cecchetelli, C. Clifford, K. Sethi, R. Zaidel-Bar, E.J. Cram, The RhoGAP SPV-1 Regulates Calcium Signaling to Control the Contractility of the Caenorhabditis Elegans Spermatheca during Embryo Transits, Molecular Biology of the Cell, 30(7), 2019, 907-922
  • A.C.E Wirshing, E.J. Cram, Spectrin Regulates Cell Contractility through Production and Maintenance of Actin Bundles in the Caenorhabditis Elegans Spermatheca, Molecular Biology of the Cell, 29(20), 2018, 2433-2449
  • C.A. Kelley, A.C.E. Wirshing, R. Zaidel-Bar, E.J. Cram The Myosin Light-Chain Kinase MLCK-1 Relocalizes during Caenorhabditis Elegans Ovulation to Promote Actomyosin Bundle Assembly and Drive Contraction, Molecular Biology of the Cell, 29(16), 2018, 1975-1991
  • A.C. Wirshing, E.J. Cram, Myosin Activity Drives Actomyosin Bundle Formation and Organization in Contractile Cells of the C. Elegans Spermatheca, Molecular Biology of the Cell, 28(14), 2017, 1815-1818

Faculty

Aug 17, 2020

Research on Extracellular Matrix Making Waves for Asthma Therapy

BioE Assistant Professor Harikrishnan Parameswaran’s research on “Intercellular communication controls agonist-induced calcium oscillations independently of gap junctions in smooth muscle cells” was published in Science Advances.

Faculty

Apr 09, 2019

FY20 TIER 1 Award Recipients

25 COE faculty and affiliates were recipients of FY20 TIER 1 Interdisciplinary Research Seed Grants for 18 different projects representing up to $900K dollars of investment in research.

Mar 22, 2016

FY17 TIER 1 Award Recipients

23 COE faculty and affiliates were recipients of FY17 TIER 1 Interdisciplinary Research Seed Grants for 12 different projects representing over $600K dollars of investment in research.

Faculty

Apr 04, 2012

FY13 TIER 1 Award Recipients

27 COE faculty and affiliates were recipients of FY13 TIER 1 Interdisciplinary Research Seed Grants for 21 different research projects.

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