Lee Makowski

About

Lee Makowski received his B.S. at Brown University in Physics, and Masters and Ph.D. at Massachusetts Institute of Technology in Electrical Engineering. After doing postdoctoral research at Brandeis University in Structural Biology, he joined faculty of the College of Physician and Surgeons at Columbia University in the Biochemistry Department. He moved to Boston University as Professor of Physics and later accepted a position as Director of the Institute of Molecular Biophysics at Florida State University. In 1998 he joined the National Science Foundation where he was a Program Director first in the Biology Directorate and then in the Division of Materials Science. From 2000 until 2010 he was at Argonne National Laboratory, first as Biosciences Division Director and then as Senior Scientist. He moved to Northeastern in the fall of 2010. He is an author of over 100 scientific research papers and numerous review articles on innovative analyses of biophysical data with focus on x-ray and neutron scattering and x-ray imaging.

Selected Publications

• Nepal, P.,  Bashit, A.A., L. Yang   and L. Makowski (2022). Small-angle x-ray microdiffraction from fibrils embedded in tissue thin sections. (submitted for publication).
• Bashit, A.A., P. Nepal, T. Connors, D.H. Oakley, B.T. Hyman,L.Yang and L. Makowski (2022) Mapping the spatial distribution of fibrillar polymorphs in human brain tissue. Frontiers in Neuroscience (in press).
• Liu, J. and L. Makowski (2022) Scanning x-ray microdiffraction:  In situ molecular imaging of tissue and materials. Current Opinion in Structural Biology (in press).
• Djagbletey, R., Aniteye, E., Darkwa, E.O., Sarpong, P., Aryee, G., Ohene, B.E., Kpodonu, J., Makowski, L. and Smallwood, C.D. (2022) A Simplified Adult Expiratory Support Device: First Clinical Cases in a Low-Resource Setting. The Annals of Thoracic Surgery, 113(3), pp.1021-1025.
• Hossain, M.A., Richa Sarin, Daniel P. Donnelly, Brandon C. Miller, Samantha Watson, Jenifer N. Winters, Jeremy B. Conway, Durgalakshmi Sivasankar, Aparna C. Ponmudiyan, Tanvi Gawde, Sunanda Kannapadi, Yunqiu Chen, Jared R. Auclair, Joseph P. Salisbury, Roman Manetsch, Mary Jo Ondrechen, Gregory A. Petsko, Lee Makowski and Jeffrey N. Agar (2022) Protein crosslinking as a therapeutic strategy for SOD1-related ALS BioRxiv.
• Billiar, K., Donald P. Gaver, Kenneth Barbee, Anita Singh, John D. DesJardins, Beth Pruitt, Joe Tranquillo, Glenn Gaudette, Beth Winkelstein, Lee Makowski, Jenny R. Amos, Ann Saterbak, Joe LeDoux, Brian Helmke, Michele Grimm, Paul Benkeser (2022) Learning Environments and Evidence-Based Practices in Bioengineering and Biomedical Engineering. 10.1007/s43683-021-00062-z
• Packer, M.R. J.A. Parker, J.K. Chung, Z. Li, Y.K. Lee,  T. Cookis, H. Guterres, S. Alvarez,  M.A. Hossain, D.P. Donnelly, J.N. Agar, L. Makowski, M. Buck, J.T. Groves, and C. Mattos. (2021) Raf promotes dimerization of the Ras G-domain with increased allosteric connections. Proceedings of the National Academy of Sciences, 118 (10).
• Makowski, Lee, Olson-Sidford, William, W. Weisel, John (2021). Biological and Clinical Consequences of Integrin Binding via a Rogue RGD Motif in the SARS CoV-2 Spike Protein. Viruses, 13(2),146. 10.3390/V13020146
• Huang, Lei, Wright, Michelle, Yang, Sichun, Blachowicz, Lydia, Makowski, Lee, Roux, Benoît (2020). Glycine substitution in SH3-SH2 connector of Hck tyrosine kinase causes population shift from assembled to disassembled state. Biochimica et Biophysica Acta – General Subjects, 1864(7),129604. 10.1016/J.BBAGEN.2020.129604
• Makowski, Lee (2020). The Structural Basis of Amyloid Strains in Alzheimer’s Disease. ACS Biomaterials Science & Engineering, 6(5),2498-2505. 10.1021/ACSBIOMATERIALS.9B01302
• Ngu, Lisa, Winters, Jenifer N., Makowski, Lee, Beuning, Penny J., Ondrechen, Mary Jo (2020). Distal Residues and Enzyme Activity: Implications for Personalized Medicine. Biophysical Journal, 118(3),535a-536a. 10.1016/J.BPJ.2019.11.2937
• Ngu, Lisa, Winters, Jenifer N., Nguyen, Kien, Ramos, Kevin E., DeLateur, Nicholas A., Makowski, Lee, Whitford, Paul C., Ondrechen, Mary Jo, Beuning, Penny J. (2020). Probing remote residues important for catalysis in Escherichia coli ornithine transcarbamoylase. PLoS ONE, 15(2),e0228487. 10.1371/JOURNAL.PONE.0228487
• B. Roig-Solvas, D.H, Brooks, L. Makowski, FiXR: A Framework to Reconstruct Fiber Cross- Sections from X-Ray Fiber Diffraction Experiments, Acta Crystallographica, 2020, D76
• B. Roig-Solvas, B.T. Hyman, L. Makowski, In Situ Saxs of Protein Deposits in Alzheimer’s Disease, bioRxiv, 2019
• L. Makowski, The Structural Basis of Amyloid Strains in Alzheimer’s Disease, ACS Biomaterials Science and Engineering, 2019
• H. Zhou, H. Guterres, C. Mattos, L. Makowski Predicting X‐Ray Solution Scattering from Flexible Macromolecules, Protein Science, 27, 2018, 2023-2036
• B. Roig-Solvas, L. Makowski, Calculation of the Cross-Sectional Shape of a Fibril from Equatorial Scattering, Journal of Structural Biology 200(3), 2017, 248-257

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