Jeffrey W. Ruberti
Professor, Bioengineering
Affiliated Faculty, Mechanical and Industrial Engineering
Research Focus
tissue engineering of load-bearing matrix (bone, cornea); bioreactor design; multi-scale mechanobiochemistry; statistical mechanics; energetics microscopy; high-resolution imaging; biopolymer self-assembly
Education
- PhD (1998), Biomedical Engineering, Tulane University
Honors & Awards
- Soren Buus Outstanding Research Award (2008), College of Engineering, Northeastern University
- Dean’s Service Award (2011), College of Engineering, Northeastern University
Teaching Interests
- Capstone Design
- Biomechanics
- Principles of Bioengineering
Professional Affiliations
- American Association for the Advancement of Science
- American Society of Mechanical Engineers International
- Biomedical Engineering Society
Research Overview
tissue engineering of load-bearing matrix (bone, cornea); bioreactor design; multi-scale mechanobiochemistry; statistical mechanics; energetics microscopy; high-resolution imaging; biopolymer self-assembly
Selected Research Projects
- Biomimetic Bone: From Nano to Micro
- – Principal Investigator, National Science Foundation
- Mechanobiology of Matrix Production
- – Principal Investigator, National Institutes of Health
Department Research Areas
Selected Publications
- H. Hosseini, A. Rangchian, M.L. Prins, C.L. Giza, J.W. Ruberti, H.P. Kavehpour, Probing Flow-Induced Biomolecular Interactions with Micro-Extensional Rheology: Tau Protein Aggregation, J. Biomech Eng., 142(3), 2020
- M. Chaudhary, E.N. Ismail, P. Yao, F. Tayyari, R.A. Radu, S. Nusinowitz, M.E. Boulton, R.S. Apte, J.W. Ruberti, J.T. Handa, P. Tontonoz, G. Malek, LXRs Regulate Features of Age-Related Macular Degeneration and May be a Potential Therapeutic Target, JCI Insight, 5(1), 2020
- J.A. Paten, C.L. Martin, J.T. Wanis, S.M. Siadat, A.M. Figueroa-Navado, J.W. Ruberti, L.F. Deravi Molecular Interactions Between Collagen and Fibronectin: A Reciprocal Relationship that Regulates De Novo Fibrillogenesis, Chem, 5, 2019, 2126-2145
- B. Wingender, P. Bradley, N. Saxena, J.W. Ruberti, L. Gower, Biomimetic Organization of Collagen Matrices to Template Bone-Like Microstructures, Matrix Biology, 52-54, 2016, 384-396
- M. Susilo, J. Paten, E. Sander, T.D. Nguyen, J.W. Ruberti Collagen Network Strengthening Following Cyclic Tensile Loading, Interface Focus, 6(1), 2016
- J.A. Paten, S. Siadat, M.E. Susilo, I.N. Ebraheim, J.L. Stoner, J.P. Rothstein, J.W. Ruberti, Flow-Induced Crystallization of Collagen: A Potentially Critical Mechanism in Early Tissue Formation, ACS Nano, 10(5), 2016, 5027-5040
Jan 14, 2021
Ruberti Awarded Patent for Mechanochemical Collagen Assembly
BioE Professor Jeffrey Ruberti was awarded a patent for designing a “Mechanochemical collagen assembly.”
May 21, 2020
Ruberti Awarded Grant for Low-Cost COVID-19 Diagnostics Testing
BioE Professor Jeffrey Ruberti, in collaboration with the University of California-Los Angeles and University of Massachusetts Amherst, was awarded a $150K NSF RAPID grant for “Low-Cost, Non-invasive, Fast Sample Collection System for COVID-19 Viral Load Level Diagnosis: Point-of-Care and Environmental Testing.”
Aug 06, 2019
Using Collagen to Help Repair Tendons
BioE Professor Jeff Ruberti is developing a method to use collagen to help speed up the recovery after a tendon is injured.
Feb 26, 2019
Ruberti Awarded Patent
BioE Professor Jeffrey Ruberti was awarded a patent for creating a “Mechanochemical collagen assembly.”
Dec 18, 2018
Five COE Projects Selected for GapFund360
Congratulations to ECE Associate Professors Kaushik Chowdhury, Raymond Fu, Matteo Rinaldi, ECE Professor Vincent Harris, and BioE Professor Jeff Ruberti whose projects were selected for Phase 1 2018 funding by Northeastern’s GapFund360 program.
Aug 21, 2018
$1M NSF Grant to Advance the Study of Single-Molecule Research
BioE Professor Jeffrey Ruberti (co-PI) along with bioengineering affiliated and College of Science faculty, including Professor Mark Williams (PI), and Associate Professors Penny Beuning (co-PI), Meni Wanunu (co-PI), and Ke Zhang (co-PI) were awarded a $1M NSF grant for the “Acquisition of a Lumick’s SuperC-TRAP correlative optical tweezers and fluorescence microscope (CTFM) system.”
Dec 19, 2016
Ruberti Awarded Patent for Collagen Fibrillar Construction
BioE Professor Jeff Ruberti was awarded a patent for “Collagen fibrillar construction” that can be used for tissue engineering.
Jun 20, 2016
Frozen Sample Extraction
Bioengineering Professor Jeffrey Ruberti was awarded a patent for “Systems, methods, & devices for frozen sample distribution”.
Nov 17, 2015
Organizing Microparticles
BioE Professor Jeffrey Ruberti was awarded a patent for "Microparticle organization".
Sep 18, 2015
Interdisciplinary Approach to Treat Vascular Diseases
ChE Assistant Professor Eno Ebong is using interdisciplinary research to search for the cause and treatment of vascular diseases that cause heart attacks and strokes.