Herbert Levine

Selected Publications

• Moffett, A.S., Deng, Y. & Levine, H. Modeling the Role of Immune Cell Conversion in the Tumor-Immune Microenvironment. Bull Math Biol 85, 93 (2023).
• Chakraborty, Priyanka, George, Jason T, Woodward, Wendy A, Levine, Herbert, Jolly, Mohit Kumar (2021). Gene expression profiles of inflammatory breast cancer reveal high heterogeneity across the epithelial-hybrid-mesenchymal spectrum. Translational Oncology, 14(4),101026. 10.1016/J.TRANON.2021.101026
• Deng, Youyuan, Chakraborty, Priyanka, Jolly, Mohit Kumar, Levine, Herbert (2021). A Theoretical Approach to Coupling the Epithelial-Mesenchymal Transition (EMT) to Extracellular Matrix (ECM) Stiffness via LOXL2. Cancers, 13(7),1609. 10.3390/CANCERS13071609
• Eliaz, Yossi, Nedelec, Francois, Morrison, Gregory, Levine, Herbert, Cheung, Margaret S. (2021). Insights From Graph Theory on the Morphologies of Actomyosin Networks with Multilinkers. Biophysical Journal, 120(3),160a. 10.1016/J.BPJ.2020.11.1147
• Jia, Dongya, Park, Jun Hyoung, Kaur, Harsimran, Jung, Kwang Hwa, Yang, Sukjin, Tripathi, Shubham, Galbraith, Madeline, Deng, Youyuan, Jolly, Mohit Kumar, Kaipparettu, Benny Abraham, Onuchic, José N., Levine, Herbert (2021). Towards decoding the coupled decision-making of metabolism and epithelial-to-mesenchymal transition in cancer. British Journal of Cancer, . 10.1038/S41416-021-01385-Y
• Salgia, Ravi, Kulkarni, Prakash, Levine, Herbert, Loughlin, Danielle T. (2021). Quantifying Cancer: More Than Just a Numbers Game. Trends in Cancer, 7(4),267-269. 10.1016/J.TRECAN.2021.02.002
• Singh, Nishant, Bartol, Thomas, Levine, Herbert, Sejnowski, Terrence, Nadkarni, Suhita (2021). Presynaptic endoplasmic reticulum regulates short-term plasticity in hippocampal synapses. Communications Biology, 4(1). 10.1038/S42003-021-01761-7
• Yu, Clare C, Wortman, Juliana C, He, Ting-Fang, Solomon, Shawn, Zhang, Robert Z, Rosario, Anthony, Wang, Roger, Tu, Travis Y, Schmolze, Daniel, Yuan, Yuan, Yost, Susan E, Li, Xuefei, Levine, Herbert, Atwal, Gurinder, Lee, Peter P (2021). Physics Approaches to the Spatial Distribution of Immune Cells in Tumors. Reports on Progress in Physics, 84(2),022601. 10.1088/1361-6633/ABCD7B
• Chakraborty, Priyanka, George, Jason T., Tripathi, Shubham, Levine, Herbert, Jolly, Mohit Kumar (2020). Comparative Study of Transcriptomics-Based Scoring Metrics for the Epithelial-Hybrid-Mesenchymal Spectrum. Frontiers in Bioengineering and Biotechnology, 8. 10.3389/FBIOE.2020.00220
• Eliaz, Yossi, Nedelec, Francois, Morrison, Greg, Levine, Herbert, Cheung, Margaret S. (2020). Insights from graph theory on the morphologies of actomyosin networks with multilinkers. Physical Review E, 102(6). 10.1103/PHYSREVE.102.062420
• J.T. George, H. Levine, Sustained Coevolution in a Stochastic Model of Cancer– Immune Interaction, Cancer Research 80(4), 2020, 811-819
• L. James, C. Bueno, Y. Eliaz, N.P. Schafer, M.N. Waxham, P.G. Wolynes, H. Levine, M.S. Cheung, The Role of the Arp2/3 Complex in Shaping the Dynamics and Structures of Branched Actomyosin Networks, Proceedings of the National Academy of Sciences, 117(20), 2020, 10825-10831
• M.K. Jolly, S.A. Mani, H. Levine, Hybrid Epithelial/Mesenchymal Phenotype(s): The ‘Fittest’ for Metastasis?, Biochimica et Biophysica Acta Reviews on Cancer (BBA), 2018
• J.T. George, D.A. Kessler, H. Levine, Effects of Thymic Selection on T Cell Recognition of Foreign and Tumor Antigenic Peptides, Proceedings of the National Academy of Sciences, 114(38), 2017, E7875-E7881
• M.K. Jolly, K.E. Ware, S. Gilja, J.A. Somarelli, H. Levine EMT and MET: Necessary or Permissive for Metastasis?, Molecular Oncology, 11 (7), 2017, 755-769

Faculty

Dec 15, 2023

Modeling How Cancer Attacks the Immune System

Physics/BioE University Distinguished Professor Herbert Levine’s research on “Modeling the Role of Immune Cell Conversion in the Tumor-Immune Microenvironment” was published in the Bulletin of Mathematical Biology.

Faculty

Jun 12, 2023

$1.2M NSF Award for Understanding Cell-Fate Transitions for Tumor Development

University Distinguished Professor Herbert Levine, physics and bioengineering, in collaboration with Brown University and MD Anderson Cancer Center, is leading a $1.2 million NSF grant for determining the “Regulation of Cellular Stemness During the Epithelial-Mesenchymal Transition (EMT).”

Faculty

Oct 12, 2021

Creating a Global Network to Explore Living Systems

University Distinguished Professor Herbert Levine, physics and bioengineering, in collaboration with Princeton University, the University of Illinois at Urbana-Champaign, William Marsh Rice University, and Yale University, is leading a $5.5M NSF grant for “International Physics of Living Systems Graduate Research Network.”

Faculty

Jul 15, 2021

Understanding microRNA Roles in Stochastic Multistable Networks

BioE Assistant Professor Mingyang Lu and Physics/BioE University Distinguished Professor Herbert Levine, in collaboration with Leonidas Bleris from the University of Texas at Dallas, were awarded a $1.4M NSF grant for “Genome Editing Approaches to Unravel microRNA Roles in Stochastic Multistable Networks.”

In the Media

Jun 07, 2021

Evolution of the Tumor and Metabolic Plasticity Discussed Through the Lens of Physics with Herbert Levine

University Distinguished Professor Herbert Levine, physics and bioengineering, was featured in the Finding Genius podcast “Evolution of the Tumor and Metabolic Plasticity Discussed Through the Lens of Physics“. Listen to the Finding Genius podcast or find it on Apple Podcasts.

Faculty

Aug 23, 2019

Levine Uses Theoretical Physics to Make Sense of Cancer

COS/BioE Professor Herbert Levine collaborates with cancer biologists to explore fundamental questions, such as how cancer spreads and why immunotherapies only work for certain patients.

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