Sandra Shefelbine
Associate Dean for Space and Special Initiatives, Office of the Dean
Professor, Mechanical and Industrial Engineering
Professor, Bioengineering
Office
- 222 ISEC
- 617.373.3199
Lab
- 260 ISEC
Related Links
Research Focus
Multi-scale bone biomechanics–how the structure and composition of bone influences its mechanical properties; mechano-adaptation of bone and joint– how tissue responds to mechanical signals
Education
PhD (2002), Mechanical Engineering, Stanford University
Honors & Awards
- 2020 Fulbright Futures Scholarship, University of Melbourne
- 2020 American Institute for Medical and Biological Engineers Fellow
- 2011 Imperial College London Rector’s Medal of Excellence in Teaching
- 2010 Royal Academy of Engineering Exxon Mobil Teaching Award
- 2010 Faculty of Engineering Outstanding Teaching Award
- 2010 Department of Bioengineering student selected ‘Best Teacher’ Award
- 2005 RCUK Academic Fellowship
- 2002 National Science Foundation International Research Fellowship
Teaching Interests
- Solid mechanics
- Dynamics
- Musculoskeletal biomechanics
Research Overview
Multi-scale bone biomechanics–how the structure and composition of bone influences its mechanical properties; mechano-adaptation of bone and joint– how tissue responds to mechanical signals
Shefelbine Lab
Shefelbine Lab conducts the following research:
Musculoskeletal mechanoadaptation: Bones are responsive to load: with increased loading, bone formation occurs, with decreased loading bone resorption occurs. Our research explores the mechano- sensitivity of bone using clinical observations, experimental models, and computational simulations.
Advanced skeletal technologies: Investigation of bone sometimes requires development of new technologies. In collaborations, this lab has developed new technologies to measure or assess musculoskeletal biomechanics.
Multiscale mechanics of bone: Bone is a natural composite material consisting of protein (mainly collagen), mineral (hydroxyapatite), and water. Like many other natural composites bone exhibits a unique combination of mechanical properties, in particular high strength and toughness. This work explores how changes in the bone building blocks at the molecular level influence its hierarchical architecture and how structural features interact across a wide range of length scales.
Selected Research Projects
- Manipulating Fluid Flow in Mechanoadaptation of Bone
- – Principal Investigator, National Science Foundation
- Mechanobiology of Joint Morphogenesis: Manipulating Salamander Limbs
- – Principal Investigator, National Science Foundation
Selected Publications
- B.K. Connizzo, J.M. Piet, S.J. Shefelbine, A.J. Grodzinsky Age-Associated Changes in the Response of Tendon Explants to Stress Deprivation is Sex-Dependent, Connective Tissue Research, 61(1), 2020, 48-6
- R.P. Main, S.J. Shefelbine, L.B. Meakin, M.J. Silva, M.C.H van der Meulen, B.M. Willie, Murine Axial Compression Tibial Loading Model to Study Bone Mechanobiology: Implementing the Model and Reporting Results, Journal of Orthopaedic Research, 38, 2020, 233–252
- B. Depalle, C.M. McGilvery, S. Nobakhti, N. Aldegaither, S.J. Shefelbine, A.E. Porter, Osteopontin Regulates Type I Collagen Fibril Formation In Bone Tissue, Acta Biomaterialia, 2020
- S.M. Sadeghian, C.L. Lewis, S.J. Shefelbine Predicting Growth Plate Orientation with Altered Hip Loading: Potential Cause of Cam Morphology, Biomech Model Mechanobiol, 19(2), 2020, 701-712
- V. Kondiboyina, L.B. Raine, A.F. Kramer, N.A. Khan, C.H. Hillman, S.J. Shefelbine, Skeletal Effects of Nine Months of Physical Activity in Obese and Healthy-Weight Children, Medicine and Sci- ence in Sports and Exercise, 52(2), 2020, 434-440
- A.E. Draghici, J.A. Taylor, M.L. Bouxsein, S.J. Shefelbine Effects of FES-Rowing Exercise on the Time-Dependent Changes in Bone Microarchitecture After Spinal Cord Injury: A Cross-Sectional Inves-tigation, JBMR Plus, 3(9), 2019, e10200
- J. Piet, D. Hu, Q. Meslier, R. Baron, S.J. Shefelbine Increased Cellular Presence After Sciatic Neurectomy Improves the Bone Mechano-adaptive Response in Aged Mice, Calcified Tissue International, 105(3), 2019, 316–330
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