Ambika Bajpayee

Assistant Professor,  Bioengineering
Affiliated Faculty,  Global Resilience Institute

Contact

Office

  • 216 ISEC
  • 617.373.7018

Related Links

Research Focus

drug delivery; bio-electrostatics; transport phenomena in biological systems; biomechanics; osteoarthritis

About

Prof. Bajpayee works on drug delivery to connective and charged tissues such as cartilage, meniscus, intervertebral disc and mucosal membranes. Her lab utilizes concepts of nanomedicine and bio-electrostatics to design polypeptides and protein-based carriers for targeted and sustained delivery of small molecule drugs, protein growth factors, antibodies and genetic materials to specific intra-tissue and intra-cellular target sites inside connective tissues. A main focus is on using charge interactions and other binding mechanisms to rationally design drug carriers that can penetrate through the dense matrix of avascular, negatively charged tissues. Her lab is also interested in understanding mechanisms leading to degenerative joint diseases (e.g., osteoarthritis) due to ageing and traumatic injuries. The group strives to combine basic science with translational research to develop biomedical technologies.

Education

  • PhD, Mechanical Engineering, Massachusetts Institute of Technology, 2015
  • MEng, Mechanical Engineering, Massachusetts Institute of Technology, 2007
  • BS, Mechanical Engineering, University of Delhi, 2006

Honors & Awards

  • 2021 Biomaterials Science Emerging Investigator
  • US Department of Defense Discovery Award
  • 2019 NIH Trailblazer Award
  • MIT Women of Excellence
  • Meredith Kamm Memorial Award in Mechanical Engineering

Teaching Interests

  • BIOE 2350, Biomechanics
  • BIOE 5650, Multiscale Biomechanics
  • BIOE5651, Fields, Forces and Flows

Professional Affiliations

  • Osteoarthritis Research Society International (OARSI)
  • Orthopaedic Research Society (ORS)
  • Society for Biomaterials (SFB)
  • Biomedical Engineering Society (BMES)

 

Research Overview

drug delivery; bio-electrostatics; transport phenomena in biological systems; biomechanics; osteoarthritis

Molecular Bioelectrostatics & Drug Delivery Laboratory

The Bajpayee lab works on drug delivery to connective and charged tissues such as cartilage, meniscus, intervertebral disc and mucosal membranes. Connective tissues are pervasive throughout the body and their degeneration affects 10% of the human population. Their dense extracellular matrix, however, hinders penetration of most drugs. We utilize concepts of nanomedicine and bio-electrostatics to design polypeptides and protein-based carriers for targeted and sustained delivery of small molecule drugs, protein growth factors, antibodies and genetic materials to specific intra-tissue and intra-cellular target sites inside connective tissues.

Bayjpayee Lab

Selected Research Projects

Selected Publications

  • Warren, M.R., Zhang, C., Vedadghavami, A., Bokvist, K., Dhal, P.K., Bajpayee, A.G. (2021). Milk Exosomes with Enhanced Mucus Penetrability for Oral Delivery of siRNA. Biomaterials Science, 9, 4260-4277. 10.1039/D0BM01497D
  • He, T., Li, B., Colombani, T., Joshi-Navare, K., Mehta, S., Kisiday, J., Bencherif, S., Bajpayee, A.G. (2021). Hyaluronic Acid-Based Shape-Memory Cryogel Scaffolds for Focal Cartilage Defect Repair. Tissue Engineering Part A, doi.org/10.1089/ten.tea.2020.0264
  • Mehta, S., Young, C.C., Warren, M.R., Akhtar, S., Shefelbine, S.J., Crane, J.D., Bajpayee, A.G. (2021). Resveratrol and Curcumin Attenuate Ex Vivo Sugar-Induced Cartilage Glycation, Stiffening, Senescence and Degradation. Cartilage, doi.org/10.1177/1947603520988768
  • Wagner, E.K., Vedadghavami, A., Jacobsen, T.D., Goel, S.A., Chahine, N.O., Bajpayee, A.G. (2020). Avidin Grafted Dextran Nanostructure Enables a Month-Long Intra-Discal Retention. Scientific Reports, 10, 12017.
  • C. Young, A. Vedadghavami, A.G. Bajpayee, Bioelectricity For Drug Delivery: The Promise of Cationic Therapeutics, Bioelectricity, 2020
  • T. He, C. Zhang, A. Vedadghavami, S. Mehta, H. Clark, R. Porter, A.G. Bajpayee, Multi-Arm Avidin Cationic Nano-Construct as a Cationic Carrier for Intra-Cartilage Delivery of Small Molecules, Journal of Controlled Release, 318, 2020, 109-123
  • S. Mehta, S. Akhtar, R.M. Porter, P. Onnerfjord, A.G. Bajpayee, IL-1Ra Is More Effective in Suppressing Cytokine Induced Catabolism in Cartilage-Synovium Co-Culture Compared to Cartilage Monoculture, Arthritis Research and Therapy, 21, 2019, 238
  • A. Vedadghavami, E.K. Wagner, S. Mehta, T. He, C. Zhang, A.G. Bajpayee, Cartilage Penetrating Cationic Peptide Carriers for Applications in Drug Delivery to Avascular Negatively Charged Tissues, Acta Biomaterialia, 93, 2018, 258-269
  • A.G. Bajpayee, A.J. Grodzinsky, Cartilage Targeting Drug Delivery: Can Electrostatic Interactions Help?, Nature Rheumatology Reviews, 13, 2017, 183-193
Boting Li

Spotlight Story

Sep 21, 2021

Bioengineering Master’s Alumna is Lead Co-Author of Research Paper Published on Cover of Tissue Engineering Part A Journal

While conducting research, Boting Li, ME’19, bioengineering, harvested biomaterials from Assistant Professor Sidi Bencherif’s lab and cell cultures from Assistant Professor Ambika Bajpayee’s lab to create a model to rebuild tissues caused by cartilage defects. While working on this project she developed a more effective protocol to harvest cells from bovine tissue. Her work to her becoming the lead co-author on a paper that was published in the June 2021 issue of Tissue Engineering Part A and featured on its cover.

cover of Tissue Engineering Part A journal

Faculty

Jun 23, 2021

COE Research Featured on Cover of Tissue Engineering Part A

Research from Assistant Professors Sidi A. Bencherif (ChE) and Ambika G. Bajpayee (BioE) on “Hyaluronic Acid-Based Shape-Memory Cryogel Scaffolds for Focal Cartilage Defect Repair” was featured on the cover of the June 2021 Tissue Engineering Part A journal.

biomaterials science cover page with graphic of research from Bioengineering lab

Faculty

Jun 16, 2021

Bajpayee’s Lab Research on Cover of Biomaterials Science Emerging Investigator Issue 2021

Research of Assistant Professor Ambika Bajpayee, bioengineering, and her team was published on the cover of the Biomaterials Science Emerging Investigator Issue 2021 of the journal Biomaterials Science. The paper, titled “Milk exosomes with enhanced mucus penetrability for oral delivery of siRNA,” was in collaboration with Sanofi. Key authors in addition to Bajpayee, include first […]

Cameron Young and Spencer Lake Jacobs-Skolik

Students

Mar 30, 2021

Two COE Students Awarded Goldwater Scholarships

Cameron Young, E’22, chemical engineering and biochemistry, and Spencer Lake Jacobs-Skolik, E’22, electrical engineering, were awarded the prestigious Barry Goldwater Scholarship, the United States’ premier award for outstanding young researchers in STEM fields.

Ambika Bajpayee

Faculty

Jan 08, 2021

Bajpayee Nominated as Biomaterials Science Emerging Investigator

BioE Assistant Professor Ambika Bajpayee was nominated as Biomaterials Science Emerging Investigator 2021 for her paper “Milk exosomes with enhanced mucus penetrability for oral delivery of siRNA.”

bajpayee looking at a vial in her lab

Faculty

Oct 08, 2020

Developing Electrically Charged Biomaterials for Drug Delivery

BioE Assistant Professor Ambika Bajpayee, in collaboration with Ryan Porter from the University of Arkansas for Medical Sciences, was awarded a $2.2M grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases for “Intra-Cartilage Depot Delivery of Electrically-Charged IL-1RA for Targeting Osteoarthritis-Associated Inflammation and Catabolism in Multiple Joint Tissues”.

bajpayee looking at a vial in her lab

Faculty

Dec 05, 2019

Developing an Oral Time Released Drug Delivery System that Lasts a Month

BioE Assistant Professor Ambika Bajpayee is developing a drug delivery system that can remain in the stomach for weeks releasing medication slowly over the course of a month.

Portraits of Bajpayee and Li

Faculty

Aug 20, 2019

Bajpayee Awarded NIH Trailblazer R21 Grant

BioE Assistant Professor Ambika Bajpayee(PI) and Jiahe Li (co-PI) were awarded a $628K NIH Trailblazer grant from the National Institute of Biomedical Imaging and Bioengineering for “Anti-Catabolic Drug Anchored Cationic Exosomes For Cartilage Targeting And Repair”.

Undergraduate

Apr 26, 2019

Wagner Named 2019 Goldwater Scholar

Earned the prestigious Barry Goldwater Scholarship, the United States’ premier award for outstanding young researchers in STEM fields.

Faculty

Feb 01, 2019

Bajpayee and Slavov Receive Sanofi iAwards

BioE Assistant Professors Ambika Bajpayee and Nikolai Slavov were each recipients of a $125K Sanofi iAward, which were created to promote scientific breakthroughs by tapping into the world’s greatest minds through close collaboration with renowned academic institutions.

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