northeastern university seal
EXPLORE NORTHEASTERN

Ambika Bajpayee

Assistant Professor,  Bioengineering
Affiliated Faculty,  Mechanical and Industrial Engineering
Affiliated Faculty,  Global Resilience Institute

Contact

Office

  • 216 ISEC
  • 617.373.7018

Related Links

Research Focus

drug delivery; bio-electrostatics; transport phenomena in biological systems; biomechanics; osteoarthritis

About

Prof. Bajpayee works on drug delivery to connective and charged tissues such as cartilage, meniscus, intervertebral disc and mucosal membranes. Her lab utilizes concepts of nanomedicine and bio-electrostatics to design polypeptides and protein-based carriers for targeted and sustained delivery of small molecule drugs, protein growth factors, antibodies and genetic materials to specific intra-tissue and intra-cellular target sites inside connective tissues. A main focus is on using charge interactions and other binding mechanisms to rationally design drug carriers that can penetrate through the dense matrix of avascular, negatively charged tissues. Her lab is also interested in understanding mechanisms leading to degenerative joint diseases (e.g., osteoarthritis) due to ageing and traumatic injuries. The group strives to combine basic science with translational research to develop biomedical technologies.

Education

  • PhD, Mechanical Engineering, Massachusetts Institute of Technology, 2015
  • MEng, Mechanical Engineering, Massachusetts Institute of Technology, 2007
  • BS, Mechanical Engineering, University of Delhi, 2006

Teaching Interests

  • BIOE 5650, Multiscale Biomechanics
  • BIOE5651, Fields, Forces and Flows

Professional Affiliations

  • Osteoarthritis Research Society International (OARSI)
  • Orthopaedic Research Society (ORS)
  • Society for Biomaterials (SFB)
  • Biomedical Engineering Society (BMES)

 

Research Overview

drug delivery; bio-electrostatics; transport phenomena in biological systems; biomechanics; osteoarthritis

Selected Publications

  • B. Pouran, V. Arbabi, A.G. Bajpayee, J.V. Tiel, J. Toyras, J.S. Jurvelin, et al., Multi-Scale Imaging Techniques to Investigate Solute Transport Across Articular Cartilage, Journal of Biomechanics, 2018
  • A.G. Bajpayee, A.J. Grodzinsky, Cartilage Targeting Drug Delivery: Can Electrostatic Interactions Help?, Nature Rheumatology Reviews, 13, 2017, 183-193
  • A.G. Bajpayee, R.E. De La Vega, M. Scheu, N.H. Varady, I.A. Yannatos, L.A. Brown, et al., Sustained Intra-Cartilage Delivery of Low Dose Dexamethasone using a Cationic carrier for Treatment of Post Traumatic Osteoarthritis, European Cell & Materials, 34, 2017, 341-364
  • A.G. Bajpayee, M.A. Quadir, P.T. Hammond, A.J. Grodzinsky, Charge Based Intra-Cartilage Delivery of Single Dose Dexamethasone Using Avidin Nano-Carriers Suppresses Cytokine-Induced Catabolism Long Term, Osteoarthritis & Cartilage, 24(1), 2016, 71-81
  • A.G. Bajpayee, A.M. Sheu, A.J. Grodzinsky, R.M. Porter, A Rabbit Model Demonstrates the Influence of Cartilage Thickness on Intra-Articular Drug Delivery and Retention within Cartilage, Journal of Orthopaedic Research, 33(5), 2015, 660-667
  • A.G. Bajpayee, A.M. Sheu, A.J. Grodzinsky, R.M. Porter, Electrostatic Interactions Enable Rapid Penetration, Enhanced Uptake and Retention of Intra-articular Injected Avidin in Rat Knee Joints, Journal of Orthopaedic Research, 32(8), 2014, 1044-1051
  • A.G. Bajpayee, C.R. Wong, M.G. Bawendi, E.H. Frank, A.J. Grodzinsky, Avidin as a Model for Charge Driven Transport into Cartilage and Drug Delivery for Treating Early Stage PTOA, Biomaterials, 35(1), 2014, 538-549
bajpayee looking at a vial in her lab

Faculty

Dec 05, 2019

Developing an Oral Time Released Drug Delivery System that Lasts a Month

BioE Assistant Professor Ambika Bajpayee is developing a drug delivery system that can remain in the stomach for weeks releasing medication slowly over the course of a month.

Portraits of Bajpayee and Li

Faculty

Aug 20, 2019

Bajpayee Awarded NIH Trailblazer R21 Grant

BioE Assistant Professor Ambika Bajpayee(PI) and Jiahe Li (co-PI) were awarded a $628K NIH Trailblazer grant from the National Institute of Biomedical Imaging and Bioengineering for “Anti-Catabolic Drug Anchored Cationic Exosomes For Cartilage Targeting And Repair”.

Undergraduate

Apr 26, 2019

Wagner Named 2019 Goldwater Scholar

Earned the prestigious Barry Goldwater Scholarship, the United States’ premier award for outstanding young researchers in STEM fields.

Faculty

Feb 01, 2019

Bajpayee and Slavov Receive Sanofi iAwards

BioE Assistant Professors Ambika Bajpayee and Nikolai Slavov were each recipients of a $125K Sanofi iAward, which were created to promote scientific breakthroughs by tapping into the world’s greatest minds through close collaboration with renowned academic institutions.

Faculty

Apr 27, 2018

BioE Professor Ambika Bajpayee receives NIH award

BioE Assistant Professor Ambika Bajpayee was awarded a $157k NIH grant for "Charge driven contrast enhanced computed tomography for imaging negatively charged tissues". The grant which will develop charge based probes for CT imaging of cartilage is a two-year R03 award with the NIH National Institute of Biomedical Imaging and Bioengineering. Read more about research […]

Spotlight Story

Feb 06, 2018

Groundbreaking Medical Research

At Northeastern University’s College of Engineering, a second-year student can be at the forefront of groundbreaking medical research. That’s exactly where Erica Wagner, BS Bioengineering 2020, finds herself right now. Working in the lab of BioE Assistant Professor Ambika Bajpayee, Wagner has been on the front lines of the creation of a new method of […]

Undergraduate

Feb 05, 2018

Erica Wagner, E’20, Receives Early Research and Creative Endeavor Award

Working in the lab of BioE Assistant Professor Ambika Bajpayee, Erica Wagner has been on the front lines of the creation of a new method of treatment for intervertebral disc issues for which she recently received the Early Research and Creative Endeavor Award.

Faculty

Aug 15, 2017

Becoming More Resilient to Aging

BioE Assistant Professor Ambika Bajapayee along with COS Assistant Professor Justin Crane propose to increase resilience in the aging population by developing novel ways of treating osteoarthritis (OA), the most common musculoskeletal disease and the leading cause of immobility.

Faculty

Mar 23, 2017

FY18 TIER 1 Award Recipients

21 COE faculty and affiliates were recipients of FY18 TIER 1 Interdisciplinary Research Seed Grants for 12 different projects representing $600K dollars of investment in research.

Faculty

Feb 01, 2017

Ambika Bajpayee receives Department of Defense Discovery Award

BioE Assistant Professor Ambika Bajpayee (PI) and MIE/BioE Associate Professor Sandra Shefelbine (Collaborator) awarded a $310K DOD Peer Reviewed Medical Research Program Discovery Award

View All Related News