Ambika Bajpayee

About

Prof. Bajpayee works on drug delivery to connective and charged tissues such as cartilage, meniscus, intervertebral disc and mucosal membranes. Her lab utilizes concepts of nanomedicine and bio-electrostatics to design polypeptides and protein-based carriers for targeted and sustained delivery of small molecule drugs, protein growth factors, antibodies and genetic materials to specific intra-tissue and intra-cellular target sites inside connective tissues. A main focus is on using charge interactions and other binding mechanisms to rationally design drug carriers that can penetrate through the dense matrix of avascular, negatively charged tissues. Her lab is also interested in understanding mechanisms leading to degenerative joint diseases (e.g., osteoarthritis) due to ageing and traumatic injuries. The group strives to combine basic science with translational research to develop biomedical technologies.

Selected Publications

• Warren, M.R., Zhang, C., Vedadghavami, A., Bokvist, K., Dhal, P.K., Bajpayee, A.G. (2021). Milk Exosomes with Enhanced Mucus Penetrability for Oral Delivery of siRNA. Biomaterials Science, 9, 4260-4277. 10.1039/D0BM01497D
• He, T., Li, B., Colombani, T., Joshi-Navare, K., Mehta, S., Kisiday, J., Bencherif, S., Bajpayee, A.G. (2021). Hyaluronic Acid-Based Shape-Memory Cryogel Scaffolds for Focal Cartilage Defect Repair. Tissue Engineering Part A, doi.org/10.1089/ten.tea.2020.0264
• Mehta, S., Young, C.C., Warren, M.R., Akhtar, S., Shefelbine, S.J., Crane, J.D., Bajpayee, A.G. (2021). Resveratrol and Curcumin Attenuate Ex Vivo Sugar-Induced Cartilage Glycation, Stiffening, Senescence and Degradation. Cartilage, doi.org/10.1177/1947603520988768
• Wagner, E.K., Vedadghavami, A., Jacobsen, T.D., Goel, S.A., Chahine, N.O., Bajpayee, A.G. (2020). Avidin Grafted Dextran Nanostructure Enables a Month-Long Intra-Discal Retention. Scientific Reports, 10, 12017.
• C. Young, A. Vedadghavami, A.G. Bajpayee, Bioelectricity For Drug Delivery: The Promise of Cationic Therapeutics, Bioelectricity, 2020
• T. He, C. Zhang, A. Vedadghavami, S. Mehta, H. Clark, R. Porter, A.G. Bajpayee, Multi-Arm Avidin Cationic Nano-Construct as a Cationic Carrier for Intra-Cartilage Delivery of Small Molecules, Journal of Controlled Release, 318, 2020, 109-123
• S. Mehta, S. Akhtar, R.M. Porter, P. Onnerfjord, A.G. Bajpayee, IL-1Ra Is More Effective in Suppressing Cytokine Induced Catabolism in Cartilage-Synovium Co-Culture Compared to Cartilage Monoculture, Arthritis Research and Therapy, 21, 2019, 238
• A. Vedadghavami, E.K. Wagner, S. Mehta, T. He, C. Zhang, A.G. Bajpayee, Cartilage Penetrating Cationic Peptide Carriers for Applications in Drug Delivery to Avascular Negatively Charged Tissues, Acta Biomaterialia, 93, 2018, 258-269
• A.G. Bajpayee, A.J. Grodzinsky, Cartilage Targeting Drug Delivery: Can Electrostatic Interactions Help?, Nature Rheumatology Reviews, 13, 2017, 183-193

Faculty

Apr 12, 2023

Cationic Contrast Agents for Cartilage Imaging for Early Diagnosis of Arthritis

Ambika Bajpayee, associate professor, bioengineering, published a paper, “Cationic Carrier Mediated Delivery of Anionic Contrast Agents in Low Doses Enable Enhanced Computed Tomography Imaging of Cartilage for Early Osteoarthritis Diagnosis,” in the journal ACS Nano. The research details the creation of positively charged contrast agents that can target cartilage tissue in joints affected by osteoarthritis, enabling CT imaging at very low doses. It demonstrates that CT scanning can be a viable imaging modality for early detection of osteoarthritis and staging of its severity.

Faculty

Aug 29, 2022

Bajpayee Awarded R21 Grant to Develop Therapies for Treating Lower Back Pain

BioE Associate Professor Ambika Bajpayee, in collaboration with Nadeen Chahine from Columbia University Health Sciences, was awarded a $222K R21 grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases for “Sustained Delivery of RhoA activator for Treatment of Intervertebral Disc Degeneration.”

Faculty

Dec 03, 2021

BioE’s Bajpayee Awarded NSF CAREER Grant for Drug Delivery Biomaterials

BioE Assistant Professor Ambika Bajpayee received a $630K NSF CAREER Award for “Developing electrically charged biomaterials for targeted drug delivery to negatively charged complex tissue environments.” Her research will investigate how to improve drug delivery in tissues within the human body that are not receptive to systemic or local drug delivery methods due to their […]

Students

Oct 29, 2021

Leading the Way in STEM Research

Cameron Young, E’22, chemical engineering and biochemistry, was nominated for the Churchill Scholarship, which funds a year of post-baccalaureate study for ambitious, accomplished young researchers in the STEM fields at Churchill College, Cambridge University. Cam Young is a dual chemical engineering and biochemistry major whose ambitions revolve around creating the next generation of personalized, pediatric […]

Spotlight Story

Sep 21, 2021

Bioengineering Master’s Alumna is Lead Co-Author of Research Paper Published on Cover of Tissue Engineering Part A Journal

While conducting research, Boting Li, ME’19, bioengineering, harvested biomaterials from Assistant Professor Sidi Bencherif’s lab and cell cultures from Assistant Professor Ambika Bajpayee’s lab to create a model to rebuild tissues caused by cartilage defects. While working on this project she developed a more effective protocol to harvest cells from bovine tissue. Her work to her becoming the lead co-author on a paper that was published in the June 2021 issue of Tissue Engineering Part A and featured on its cover.

Faculty

Jun 23, 2021

COE Research Featured on Cover of Tissue Engineering Part A

Research from Assistant Professors Sidi A. Bencherif (ChE) and Ambika G. Bajpayee (BioE) on “Hyaluronic Acid-Based Shape-Memory Cryogel Scaffolds for Focal Cartilage Defect Repair” was featured on the cover of the June 2021 Tissue Engineering Part A journal.

Faculty

Jun 16, 2021

Bajpayee’s Lab Research on Cover of Biomaterials Science Emerging Investigator Issue 2021

Research of Assistant Professor Ambika Bajpayee, bioengineering, and her team was published on the cover of the Biomaterials Science Emerging Investigator Issue 2021 of the journal Biomaterials Science. The paper, titled “Milk exosomes with enhanced mucus penetrability for oral delivery of siRNA,” was in collaboration with Sanofi. Key authors in addition to Bajpayee, include first […]

Students

Mar 30, 2021

Two COE Students Awarded Goldwater Scholarships

Cameron Young, E’22, chemical engineering and biochemistry, and Spencer Lake Jacobs-Skolik, E’22, electrical engineering, were awarded the prestigious Barry Goldwater Scholarship, the United States’ premier award for outstanding young researchers in STEM fields.

Faculty

Jan 08, 2021

Bajpayee Nominated as Biomaterials Science Emerging Investigator

BioE Assistant Professor Ambika Bajpayee was nominated as Biomaterials Science Emerging Investigator 2021 for her paper “Milk exosomes with enhanced mucus penetrability for oral delivery of siRNA.”

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