drug delivery; bio-electrostatics; transport phenomena in biological systems; biomechanics; osteoarthritis
Prof. Bajpayee works on drug delivery to connective and charged tissues such as cartilage, meniscus, intervertebral disc and mucosal membranes. Her lab utilizes concepts of nanomedicine and bio-electrostatics to design polypeptides and protein-based carriers for targeted and sustained delivery of small molecule drugs, protein growth factors, antibodies and genetic materials to specific intra-tissue and intra-cellular target sites inside connective tissues. A main focus is on using charge interactions and other binding mechanisms to rationally design drug carriers that can penetrate through the dense matrix of avascular, negatively charged tissues. Her lab is also interested in understanding mechanisms leading to degenerative joint diseases (e.g., osteoarthritis) due to ageing and traumatic injuries. The group strives to combine basic science with translational research to develop biomedical technologies.
- PhD, Mechanical Engineering, Massachusetts Institute of Technology, 2015
- MEng, Mechanical Engineering, Massachusetts Institute of Technology, 2007
- BS, Mechanical Engineering, University of Delhi, 2006
- BIOE 5650, Multiscale Biomechanics
- BIOE5651, Fields, Forces and Flows
- Osteoarthritis Research Society International (OARSI)
- Orthopaedic Research Society (ORS)
- Society for Biomaterials (SFB)
- Biomedical Engineering Society (BMES)
- B. Pouran, V. Arbabi, A.G. Bajpayee, J.V. Tiel, J. Toyras, J.S. Jurvelin, et al., Multi-Scale Imaging Techniques to Investigate Solute Transport Across Articular Cartilage, Journal of Biomechanics, 2018
- A.G. Bajpayee, A.J. Grodzinsky, Cartilage Targeting Drug Delivery: Can Electrostatic Interactions Help?, Nature Rheumatology Reviews, 13, 2017, 183-193
- A.G. Bajpayee, R.E. De La Vega, M. Scheu, N.H. Varady, I.A. Yannatos, L.A. Brown, et al., Sustained Intra-Cartilage Delivery of Low Dose Dexamethasone using a Cationic carrier for Treatment of Post Traumatic Osteoarthritis, European Cell & Materials, 34, 2017, 341-364
- A.G. Bajpayee, M.A. Quadir, P.T. Hammond, A.J. Grodzinsky, Charge Based Intra-Cartilage Delivery of Single Dose Dexamethasone Using Avidin Nano-Carriers Suppresses Cytokine-Induced Catabolism Long Term, Osteoarthritis & Cartilage, 24(1), 2016, 71-81
- A.G. Bajpayee, A.M. Sheu, A.J. Grodzinsky, R.M. Porter, A Rabbit Model Demonstrates the Influence of Cartilage Thickness on Intra-Articular Drug Delivery and Retention within Cartilage, Journal of Orthopaedic Research, 33(5), 2015, 660-667
- A.G. Bajpayee, A.M. Sheu, A.J. Grodzinsky, R.M. Porter, Electrostatic Interactions Enable Rapid Penetration, Enhanced Uptake and Retention of Intra-articular Injected Avidin in Rat Knee Joints, Journal of Orthopaedic Research, 32(8), 2014, 1044-1051
- A.G. Bajpayee, C.R. Wong, M.G. Bawendi, E.H. Frank, A.J. Grodzinsky, Avidin as a Model for Charge Driven Transport into Cartilage and Drug Delivery for Treating Early Stage PTOA, Biomaterials, 35(1), 2014, 538-549
Dec 05, 2019
BioE Assistant Professor Ambika Bajpayee is developing a drug delivery system that can remain in the stomach for weeks releasing medication slowly over the course of a month.
Aug 20, 2019
BioE Assistant Professor Ambika Bajpayee(PI) and Jiahe Li (co-PI) were awarded a $628K NIH Trailblazer grant from the National Institute of Biomedical Imaging and Bioengineering for “Anti-Catabolic Drug Anchored Cationic Exosomes For Cartilage Targeting And Repair”.
Apr 26, 2019
Earned the prestigious Barry Goldwater Scholarship, the United States’ premier award for outstanding young researchers in STEM fields.
Feb 01, 2019
BioE Assistant Professors Ambika Bajpayee and Nikolai Slavov were each recipients of a $125K Sanofi iAward, which were created to promote scientific breakthroughs by tapping into the world’s greatest minds through close collaboration with renowned academic institutions.
Apr 27, 2018
BioE Assistant Professor Ambika Bajpayee was awarded a $157k NIH grant for "Charge driven contrast enhanced computed tomography for imaging negatively charged tissues". The grant which will develop charge based probes for CT imaging of cartilage is a two-year R03 award with the NIH National Institute of Biomedical Imaging and Bioengineering. Read more about research […]
Feb 06, 2018
At Northeastern University’s College of Engineering, a second-year student can be at the forefront of groundbreaking medical research. That’s exactly where Erica Wagner, BS Bioengineering 2020, finds herself right now. Working in the lab of BioE Assistant Professor Ambika Bajpayee, Wagner has been on the front lines of the creation of a new method of […]
Feb 05, 2018
Working in the lab of BioE Assistant Professor Ambika Bajpayee, Erica Wagner has been on the front lines of the creation of a new method of treatment for intervertebral disc issues for which she recently received the Early Research and Creative Endeavor Award.
Aug 15, 2017
BioE Assistant Professor Ambika Bajapayee along with COS Assistant Professor Justin Crane propose to increase resilience in the aging population by developing novel ways of treating osteoarthritis (OA), the most common musculoskeletal disease and the leading cause of immobility.
Mar 23, 2017
21 COE faculty and affiliates were recipients of FY18 TIER 1 Interdisciplinary Research Seed Grants for 12 different projects representing $600K dollars of investment in research.
Feb 01, 2017
BioE Assistant Professor Ambika Bajpayee (PI) and MIE/BioE Associate Professor Sandra Shefelbine (Collaborator) awarded a $310K DOD Peer Reviewed Medical Research Program Discovery Award